Multicomponent Reactions of Carbonyl Compounds and Derivatives of Cyanoacetic Acid: Synthesis of Carbo- and Heterocycles

Abstract

M u l t i c o m p o n e n t R e a c t i o n s o f C a r b o n y l C o m p o u n d s

A one-pot procedure for the synthesis of novel pyran-fused dicyanoanilines via a triethylamine/aqueous mediated pseudo four-component reaction

“…It should be noted that malononitrile is a very convenient reagent for many MCRs due to having a reactive methylene and two cyano groups to build several carbon-carbon and carbon-heteroatom bonds simoltaneously. 29 Thus, a pseudo four-component process takes place and a new series of dicyanoanilines 4 is obtained (Scheme 1). Although there is a few reports on the synthesis of benzochromene based dicyanoanilines, 13,30 as far as we know, this is the first general report on the synthesis of isochroman containing dicyanoanilines.…”

Ultrasound-promoted, rapid, green, one-pot synthesis of 2′-aminobenzothiazolomethylnaphthols via a multi-component reaction, catalyzed by heteropolyacid in aqueous media

“…By minimizing the number of synthetic operations while maximizing the build-up of structural and functional complexities, these reactions are particularly appealing in the context of target-oriented synthesis (Mironovo, 2006;Shestopalov et al, 2008;Toure´and Hall, 2009;Zhang and Zhang, 2009;Zhu and Bienayme, 2005).…”

Novel one-pot, three component synthesis of alkyl 6-aryl-3-methylpyridazine-4-carboxylates in water

“…To the best of our knowledge, there are no reports in the literature for the formation of pyridazine derivatives via condensation of β-ketoesters with arylglyoxals in water. Currently, multicomponent reactions are being rapidly developed 20 because using a "onepot" methodology makes the synthesis simpler and more environmentally friendly. Additionally, the prospect of extending one-pot reactions into combinatorial and solid-phase syntheses 21,22 promises manifold opportunities for developing novel lead structures of pharmaceuticals, catalysts and even novel molecule-based materials.…”