Multicomponent spectrometric analysis of drugs and their preparations

Ahmad, Iqbal; Sheraz, Muhammad Ali; Ahmed, Sofia; Anwar, Zubair

doi:10.1016/bs.podrm.2018.11.002

Cited by 5 publications

(3 citation statements)

References 116 publications

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“…To our knowledge, there is no other analytical method that was capable of analyzing the four combined APIs simultaneously by using HPTLC. The currently available methods that are based on HPLC and Chemometric UV visible spectrophotometry methods can only capable of analyzing the two or three APIs combinations [26][27][28][29][30][31]. Only three HPLC methods are reported that simultaneously determine the four API ingredients targeted in this method development [32][33][34].…”

Section: Analysis Of the Tablet Dosage Forms (Flu-stop And Cold Flu)mentioning

confidence: 99%

High performance thin layer chromatography (HPTLC) method development and validation for the simultaneous determination of paracetamol, caffeine, chlorpheniramine and phenylepherine in tablet formulation

Arage

Layloff

Hymete

et al. 2023

AChrom

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A rapid, selective, and precise high performance thin layer chromatographic method was developed and validated for the simultaneous analysis of paracetamol, caffeine, phenylephrine and chlorpheniramine in tablets. The chromatographic analysis was carried out on glass plates pre-coated with silica gel 60 F254 as a stationary phase. The optimized mobile phase was methanol : n-butanol : toluene : acetic acid (8:6:4:0.2 v/v). TLC chamber of 10 × 20 cm was used with saturation time of 15 min. The retardation factor (RF) for chlorpheniramine, phenylephrine, caffeine and paracetamol was found to be 0.15 ± 0.02, 0.29 ± 0.02, 0.50 ± 0.02, 0.68 ± 0.02 respectively. Detection was carried out at 212 nm. Validation study was done following ICH Q2 (R1) guideline. The regression data for the calibration plots showed good linear relationship with R 2 = 0.997 over the concentration range of 300–1,500 ng band−1 for caffeine, R 2 = 0.996 over the concentration range of 100–500 ng band−1 for phenylephrine, R 2 = 0.996 over the concentration range of 200–600 ng band−1 for chlorpheniramine, R 2 = 0.998 over the concentration range of 400–2,400 ng band−1 for paracetamol. The method was validated for precision, accuracy and recovery. Minimum detectable amounts were found to be 304.9 ng band−1, 87.88 ng band−1, 117.18 ng band−1 and 143.06 ng band−1 for caffeine, phenylephrine, chlorpheniramine, and paracetamol respectively while the limit of quantification was found to be 923.95 ng band−1, 266.32 ng band−1, 355.11 ng band−1, and 433.53 ng band−1 in the same order. The method was successfully applied to analyze two marketed tablets in a selective and reproducible manner.

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Section: Analysis Of the Tablet Dosage Forms (Flu-stop And Cold Flu)mentioning

confidence: 99%

High performance thin layer chromatography (HPTLC) method development and validation for the simultaneous determination of paracetamol, caffeine, chlorpheniramine and phenylepherine in tablet formulation

Arage

Layloff

Hymete

et al. 2023

AChrom

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“…Few studies regarding the uptake and translocation of organic NDVs that were administered via trunk injection or seed treatment are available. For seed treatment, most studies on inorganic NDVs seem to focus on the effect of NDVs on seed germination and subsequent plant growth and development, ,,, rather than quantifying their uptake and translocation. Indeed, when germinating seeds are incubated in a medium containing NDVs, many plant tissues could be directly exposed to the NDVs, such as the seed tegument and the incipient roots and leaves, making it difficult to distinguish the entrance pathway and whether translocation has occurred.…”

Section: Comments On Other Administration Routesmentioning

confidence: 99%

Critical Review: Uptake and Translocation of Organic Nanodelivery Vehicles in Plants

Stolte Bezerra Lisboa Oliveira,

Ristroph

2024

Environ. Sci. Technol.

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Nanodelivery vehicles (NDVs) are engineered nanomaterials (ENMs) that, within the agricultural sector, have been investigated for their ability to improve uptake and translocation of agrochemicals, control release, or target specific tissues or subcellular compartments. Both inorganic and organic NDVs have been studied for agrochemical delivery in the literature, but research on the latter has been slower to develop than the literature on the former. Since the two classes of nanomaterials exhibit significant differences in surface chemistry, physical deformability, and even colloidal stability, trends that apply to inorganic NDVs may not hold for organic NDVs, and vice versa. We here review the current literature on the uptake, translocation, biotransformation, and cellular and subcellular internalization of organic NDVs in plants following foliar or root administration. A background on nanomaterials and plant physiology is provided as a leveling ground for researchers in the field. Trends in uptake and translocation are examined as a function of NDV properties and compared to those reported for inorganic nanomaterials. Methods for assessing fate and transport of organic NDVs in plants (a major bottleneck in the field) are discussed. We end by identifying knowledge gaps in the literature that must be understood in order to rationally design organic NDVs for precision agrochemical nanodelivery.

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“…Современным направлением спектрофотометрии, используемым для анализа сложных многокомпонентных смесей лекарственных средств, являются хемометрические подходы с привлечением математической обработки спектров, например, методом главных компонент [17].…”

Section: традиционные методы изучения лекарств: краткий обзорunclassified

Drug Analysis Methods

Shumyantseva

Булко

Koroleva

2019

BMCRM

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Modern methods of analysis of drugs for their quantitative assessment are considered. Particular attention is paid to the electrochemical methods of drug registration, based on the reaction of electrooxidation of molecules. Systems and materials for modifying electrodes are described, as well as methods for producing modified electrodes for electrochemical reactions on the surface of electrodes. The authors present data on the electroanalysis of acetaminophen, diclofenac, ibuprofen, omeprazole, using electrodes modified with carbon nanomaterials based on carbon nanotubes and graphene. It was shown that electroanalytical methods allow the registration of therapeutic drugs in a wide range of detectable concentrations (0.1 μМ - 10 mM), which can be used to work with biological fluids (plasma, blood, urine), to conduct drug monitoring and study drug-drug interactions.

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Multicomponent spectrometric analysis of drugs and their preparations

Cited by 5 publications

References 116 publications

High performance thin layer chromatography (HPTLC) method development and validation for the simultaneous determination of paracetamol, caffeine, chlorpheniramine and phenylepherine in tablet formulation

High performance thin layer chromatography (HPTLC) method development and validation for the simultaneous determination of paracetamol, caffeine, chlorpheniramine and phenylepherine in tablet formulation

Critical Review: Uptake and Translocation of Organic Nanodelivery Vehicles in Plants

Drug Analysis Methods

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