Multicomponent synthesis of α-acylamino and α-acyloxy amide derivatives of desmycosin and their activity against gram-negative bacteria

Synthesis and characterization of thiophene-derived palladium(ii) complex immobilized on FSM-16 and its application in the novel synthesis of 7-(aryl)-7,12-dihydro-6H-indeno[1,2,4]triazolo[1,5-a]pyrimidine-6-one derivatives

“…[43][44][45][46] Many powerful pharmaceutical products, biologically active compounds, and natural products contain bicyclic heterocycles fused with a pyrimidine. [47][48][49][50][51][52] Among this plethora of combinations, the triazolo pyrimidines scaffolding was considered dramatically in natural compounds. Also, different triazolo pyrimidine derivatives have anti-inammatory, antiviral, and anti-cancer properties.…”

The 100 facets of the Passerini reaction

“…A long range highly diastereoselective Passerini reaction is rarely reported, an exception being the reaction on desmycosin 190, a natural macrolide antibiotic, characterized by a CH 2 CHO group, reported by Wessjohann ( Scheme 51 ). 109 Only two reactions were reported affording 191 but, using propanoic acid, the d.r. was very good considering the distance between the functional group and the closest stereogenic centre.…”

Fusion of Cellulose and Multicomponent Reactions: Benign by Design

“…In modern organic syntheses, a wide range of named MCRs, for example Gewald, Groebke–Blackburn–Bienaymé (GBB), Passerini, Ugi, Biginelli, Mannich, and Petasis as well as assorted new reported MCRs − have been extensively deployed in the synthesis of a diverse range of heterocyclic scaffolds, − biologically active small molecules, − natural products, and preparation of macrocyclic structures . To expand the repertoire of using MCRs in state-of the-art technology, an assortment of MCRs strategies implemented in the field of medicinal chemistry, drug discovery, , polymerization, , and even materials functionalization deployed in biosensors, water treatment, gene delivery, catalysis, enzyme immobilization, ligation and bioconjugation, construction of covalent organic frameworks (COFs), and even producing vaccines has been developed.…”