Multicomponent Training Prevents Memory Deficit Related to Amyloid-β Protein-Induced Neurotoxicity

Abstract

Background: Alzheimer’s disease (AD) is characterized by the accumulation of the amyloid-β peptide in the brain, leading to early oxidative stress and neurotoxicity. It has been suggested that physical exercise could be beneficial in preventing AD, but studies with multicomponent training are scanty. Objective: Verify the effects of multicomponent exercise training to prevent deficits in recognition memory related to Aβ neurotoxicity. Methods: We subjected Wistar rats to multicomponent training (including aerobic and anaerobic physical exercise and cognitive exercise) and then infused amyloid-β peptide into their hippocampus. Results: We show that long-term multicomponent training prevents the amyloid-β-associated neurotoxicity in the hippocampus. It reduces hippocampal lipid peroxidation, restores antioxidant capacity, and increases glutathione levels, finally preventing recognition memory deficits. Conclusion: Multicomponent training avoids memory deficits related to amyloid-β neurotoxicity on an animal model.

Analysis of factors related to cognitive impairment in a community‐based, complete enumeration survey in Japan: the Nakayama study

“…36 There were some reports that exercise reduces beta-amyloid deposition and prevents amyloid-β-associated neurotoxicity in the brain. [37][38][39] AD participants had low ADL and lack of exercise habits in the present study, and it is suggested that these factors and dementia are related to each other, as in previous studies.…”

Does Preoperative Cognitive Optimization Improve Postoperative Outcomes in the Elderly?

“…Thirdly, clinical and preclinical studies suggest that combining preoperative cognitive training and other interventions likely provides increased benefits for cognitive outcomes. Exercise is one of the most studied interventions and is suggested to improve postoperative cognitive functions when provided alongside cognitive training [86]. Interventions based on the possible pathophysiology of PND, such as the application of anti-inflammatory agents for the prevention of neuroinflammation, will likely be effective when combined with cognitive training [88,89].…”

“…Dare et al recently reported that combined physical and cognitive exercise reversed recognition memory deficits for a prolonged period and restored the acetylcholinesterase activity altered by amyloid-β neurotoxicity in the hippocampus in rats [85]. Similarly, multicomponent training, including aerobic and anaerobic physical exercise and cognitive exercise, was shown to prevent memory deficits related to amyloid-β neurotoxicity in the hippocampus in rats by Soares et al [86]. The independent effect of cognitive training is reported to improve performance in memory tasks in ischemia-received rats [87].…”

Editorial: Molecular mechanisms of Alzheimer’s disease: From top to bottom

“…Some non-pharmacological interventions have been investigated and show promissory effects. Between them, we highlighted the different types of physical exercise, which act by multiple neuroprotective mechanisms (Daré et al, 2020;Soares et al, 2021). However, until now, there is no curative treatment for AD, and researchers are still struggling to find therapeutic targets that promote significant improvements in the clinical conditions of Alzheimer's patients (Knopman et al, 2021).…”