Multicyclic topology-enhanced micelle stability and pH-sensitivity

Ma, Wei; Li, Shuang; Ma, Liang; Yu, Cui‐Yun; Wei, Hua

doi:10.1016/j.eurpolymj.2022.111446

Cited by 6 publications

(3 citation statements)

References 40 publications

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“…The model drug DOX used herein can be also used as a fluorescent dye for direct monitoring the endocytosis properties of the nanomedicines. [27] After staining of the cell nucleus with DAPI, the clearly visualized merged pink colors by CLSM support that both zwitterionic nanomedicines can efficiently transport the anticancer drug to the cells and further exert the therapeutic action on the nucleus. The cellular uptake properties were further quantified using flow cytometry (FCM) analysis (Figure 8a).…”

Section: In Vitro Cellular Uptake and Cytotoxicity Studiesmentioning

confidence: 74%

“…Thus, the critical micelle concentrations (CMCs) of both zwitterionic copolymers were investigated using pyrene as a fluorescence probe. [27,44] The CMCs of PCL 25 -b-OPDEA 32 and PCL 25 -SS-OPDEA 30 were determined to be 0.036 and 0.007 mg mL −1 by analyzing the characteristic emission intensity ratio (I 384 /I 373 ) with the polymer concentrations in the pyrene emission spectra (Figure 4). The CMC value of PCL 25 -SS-OPDEA 30 significantly lower than that of PCL 25 -b-OPDEA 32 implies the greater colloidal stability of the former micelle constructs attributed likely due to the different structures of the two polymers, including the additional incorporation of a hydrophobic disulfide linker and the different DPs of hydrophilic OPDEA block.…”

Section: Characterization Of Zwitterionic Nanomedicinesmentioning

confidence: 99%

“…The introduction of stimulus-responsive chemical groups to nanomedicines is thus a more versatile approach. [25] Tremendous stimuli-responsive polymers capable of responding to the tumor microenvironment signals including pH, [26][27][28] temperature, [29,30] reactive oxy-gen species, [31][32][33] and glutathione (GSH) [34,35] have been developed so far. Of the reported stimuli approaches, the application of GSH-sensitive polymers containing disulfide bridges is of particular importance owing to the distinct difference in the GSH levels between normal cells (≈2 mm) and specific tumor cells (≈10 mm).…”

Section: Introductionmentioning

confidence: 99%

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Fabrication of GSH‐Responsive Poly(Tertiary Amine‐Oxide)‐Based Nanomedicines for Enhanced Anticancer Drug Release

Zhang,

Ma,

Wang

et al. 2023

Macro Chemistry & Physics

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Poly(tertiary amine‐oxide)‐based polymeric nanocarriers have showed more functionalities than stealthy PEG‐based analogs due to the structure of phospholipid affinitive N‐oxides groups, which has attracted considerable attention to the synthesis of various zwitterionic copolymers with tertiary amine‐oxide grafts for enhanced anticancer drug delivery. However, poly(tertiary amine‐oxide)‐based amphiphilic copolymers with tumor intracellular microenvironment sensitivities, to the knowledge, have been rarely reported likely due to the lack of a controlled synthetic strategy. Herein, a reducible zwitterionic copolymer, poly(ε‐caprolactone)25‐SS‐poly(2‐(N‐oxide‐N,N‐diethylamino)ethyl methacrylate)30 (PCL25‐SS‐OPDEA30) is designed and synthesized successfully via combination of controlled polymerization techniques and post polymerization modification. Specifically, postoxidation of poly(tertiary amine) is confirmed to be a better synthetic strategy toward a well‐defined polymer structure relative to direct polymerization of N,N‐diethylaminoethyl methacrylate (ODEA). The effect of disulfide bridges on the self‐assembly behaviors, in vitro drug loading and drug release properties is investigated in detail. Notablely, the resulting micelles self‐assembled from PCL25‐SS‐OPDEA30 show much greater colloidal stability, higher drug loading content (DLC), and better in vitro tumor cell inhibition than the reduction‐insensitive counterparts. Overall, this study reports a robust strategy toward zwitterionic nanomedicines for on‐demand anticancer drug delivery.

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Section: In Vitro Cellular Uptake and Cytotoxicity Studiesmentioning

confidence: 74%

Section: Characterization Of Zwitterionic Nanomedicinesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Fabrication of GSH‐Responsive Poly(Tertiary Amine‐Oxide)‐Based Nanomedicines for Enhanced Anticancer Drug Release

Zhang,

Ma,

Wang

et al. 2023

Macro Chemistry & Physics

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Nickel‐asparagine complex fixed on a magnetic substrate as a precursor for preparing substituted acridines

Abbaszadehghan,

Poursattar Marjani,

Bibak

et al. 2023

Applied Organom Chemis

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In this work, an efficient, novel, retrievable, and magnetic heterogeneous nanocatalyst, Fe3O4@CPTMS@Asp@Ni was successfully fabricated using Fe3O4 nanoparticles as the core that were coated with surfactant and 3‐chloropropyltrimethoxysilan and deposited asparagine and nickel metal that can be used in multicomponent reactions for the synthesis of acridines derivatives with high yield in short reaction times. The virtue of obtained nanocatalyst was identified using transmission electron microscopy, scanning electron microscopy, Fourier transform infrared spectroscopy, X‐ray diffraction analysis, energy dispersive X‐ray, Brunauer–Emmett–Teller, vibrating sample magnetometry, Raman, and thermogravimetric analysis. The X‐ray diffraction analysis studies demonstrate that the average crystallite sizes of the prepared nanocatalyst are estimated to be about 45.4 nm. Also, the vibrating sample magnetometry measurement shows saturation magnetization values (Ms) of 7 emu/g for Fe3O4@CPTMS@Asp@Ni nanocatalyst. Also, after the synthesis steps, the application of the prepared nanocatalyst in the preparation of acridine‐1,8(2H,5H)‐diones has been investigated. Then to evaluate and assess the efficiency of the nanocatalyst as mentioned above, and its effect on the synthesis of divergent acridines via a one‐pot, three‐component condensation reaction of cyclic 1,3‐dione, aryl glyoxal, with ammonium acetate in the water as green solvent was studied. Also, when investigating the reusability of this catalyst, it was observed that Fe3O4@CPTMS@Asp@Ni nanocatalyst could be reused at least five times without losing its efficiency. High efficiency, outstanding yields in quick intervals, easy separation using a magnetic field, and possessing reusability are significant benefits of the attained nanocatalyst.

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A multivalent polyphenol–metal-nanoplatform for cascade amplified chemo-chemodynamic therapy

Li,

Zhao,

et al. 2024

Acta Biomaterialia

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Multicyclic topology-enhanced micelle stability and pH-sensitivity

Cited by 6 publications

References 40 publications

Fabrication of GSH‐Responsive Poly(Tertiary Amine‐Oxide)‐Based Nanomedicines for Enhanced Anticancer Drug Release

Fabrication of GSH‐Responsive Poly(Tertiary Amine‐Oxide)‐Based Nanomedicines for Enhanced Anticancer Drug Release

Nickel‐asparagine complex fixed on a magnetic substrate as a precursor for preparing substituted acridines

A multivalent polyphenol–metal-nanoplatform for cascade amplified chemo-chemodynamic therapy

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