Multidetector computed tomography evaluation of synchronous lymphoma and other solid malignancies

El‐Badrawy, Adel; Gadelhak, Basma; Helmy, Eman; Farouk, Omar; Fady, Tamer; Refky, Basel; Elzaafarany, Maha; Emarah, Ziad; Taalab, Mona M.; Eisa, Noha; El-Etreby, Shahira; Bahgat, Monir; El-Badrawy, Mohammad Khairy; Elalfy, Hatem; Besheer, Tarek; El-Mesery, Ahmed; Akl, Mohamed Farouk; Megahed, Nirmeen; Khashaba, Eman

doi:10.4103/jcrt.jcrt_325_17

Cited by 3 publications

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“…Liver and HCC imaging has long relied on CT for initial tumor definition and post-treatment follow-up to evaluate response to therapy [14]. Using MDCT is an effective way to assess synchronous primary solid double malignancies [15][16][17][18][19][20][21][22][23]. This is in line with our findings, which show that MDCT correctly identified all 148 cancers.…”

Section: Discussionsupporting

confidence: 85%

Multi-detector computed tomography evaluation of synchronous hepatocellular carcinoma and other solid malignancies

El‐Badrawy¹

2022

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Aim of the study:To review the findings of multi-detector computed tomography (MDCT) in synchronous hepatocellular carcinoma (HCC) and other solid malignancies. Material and methods: A total of 74 cases were included in this retrospective analysis, all of them confirmed with a diagnosis of synchronous HCC and other solid malignancies. They were 41 women and 33 men (mean age, 63.36 years). The whole body and triphasic abdominal CT scanning utilized 128 MDCT scanners in all 74 patients. The pathological diagnoses of all 148 malignancies were confirmed in all 74 cases. Results: Out of 3480 patients with HCC, 74 patients (2.1%) were diagnosed with another synchronous primary solid malignancy. The pathology of all 148 cancers was verified, and each one was correctly characterized, assessed, and staged. Hepatocellular carcinoma was detected in all 74 patients. The most frequent extra-hepatic primary malignant sites were breast (18/74, 24.3%), followed by kidney (15/74, 20.3%), lymphoma (9/74, 12.2%), uterus (7/74, 9.5%), ovary (5/74, 6.8%), colon (5/74, 6.8%), prostate (5/74, 6.8%), urinary bladder (3/74, 4.1%), thyroid (2/74, 2.7%), gall bladder (1/74, 1.4%), stomach (1/74, 1.4%), pancreas (1/74, 1.4%), esophagus (1/74, 1.4%) and lung (1/74, 1.4%). Conclusions:The possibility of synchronous double malignancies with HCC should always be considered during pretreatment evaluation. Using an MDCT scanner, researchers were able to assess this occurrence accurately. An increased number of such findings may lead to an improved therapeutic method for these patients.

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Section: Discussionsupporting

confidence: 85%

Multi-detector computed tomography evaluation of synchronous hepatocellular carcinoma and other solid malignancies

El‐Badrawy¹

2022

ceh

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“…Advancements in diagnostic technologies have improved the identification of MPMTs. Multidetector CT, 26 PET/CT, 27 PET/MRI, 28 and endoscopy 29 have been reported to be highly efficient at detecting synchronous tumors. Molecular profiling is also a useful diagnostic tool, particularly when differential diagnosis between SPMTs and metastasis cannot be confirmed by histomorphology 30–32 .…”

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confidence: 99%

Different situations of identifying second primary malignant tumors in lymphoma patients with synchronous solid tumors

et al. 2023

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Background To our knowledge, the different situations of identifying second primary malignant tumors (SPMTs) in lymphoma patients with synchronous solid tumors remain to be comprehensively investigated. Methods We retrospectively collected information pertaining to lymphoma patients with synchronous solid tumors (diagnosed within 6 months) at Peking University Cancer Hospital & Institute between 2009 and 2019. The non‐parametric Aalen–Johansen estimator was applied to calculate cumulative incidence function in the competing risk model. Furthermore, propensity score‐matched analysis was performed to compare survival differences in lymphoma patients with or without synchronous solid tumors. Results Thirty‐eight patients were enrolled. There were three situations of identifying SPMTs. First, in 15 patients (39.5%), SPMTs were identified before the initiation of any treatment. Among them, priority was given to anti‐lymphoma treatment in case of only three patients. Second, in 17 patients (44.7%), SPMTs were unexpectedly detected on surgical specimen assessment; of them, 13 received anti‐lymphoma treatment after surgery. Third, in six patients (15.8%), SPMTs were identified after the outset of treatment for the primary tumor; in this population, three of four patients with lymphoma switched toward the treatment plan for SPMTs. The 5‐year overall survival was 58.7%. The cumulative incidence function within 5 years was 26.6% for lymphoma and 14.7% for other solid tumors. The early identification of SPMTs was associated with better outcomes (p = 0.048). After balancing the baseline characteristics, no differences in survival were observed between lymphoma patients with and without synchronous solid tumors (p = 0.664). Conclusions This is the first study to present the different situations of identifying SPMTs in lymphoma patients with synchronous solid tumors. In only <50% patients, SPMTs were identifiable at baseline. SPMT identification at different situations may make it difficult to choose the optimal therapeutic option, which may consequently impact patient survival.

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MDCT diagnosis of synchronous primary gastrointestinal tract carcinoma and other solid malignancies: case series study

El‐Badrawy

Shebel

Atta

2022

Egypt J Radiol Nucl Med

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Background The presentation of synchronous multiple primary tumors is rare. The aim of this report was to report an uncommon series of cases diagnosed with synchronous gastrointestinal tract carcinoma and other solid malignancies by multidetector computed tomography. Case presentation Our report included 34 patients with synchronous gastrointestinal tract carcinoma and other solid malignancies from November 2009 to September 2019. They were 14 men and 20 women (mean age, 65.5 year; range, 52–82 years). The highest number of GIT cases were colonic carcinomas detected in 70% (24/34) of the patients. The most frequent extra-gastrointestinal primary malignancy sites were renal cell and breast carcinomas, 17.6% (6/34) of each. Conclusions Careful preoperative evaluation is recommended to detect this pattern of synchronous extra-gastrointestinal tumors. More reports of such cases should help to clarify the pathogenesis of this phenomenon and may lead to a new treatment strategy for synchronous gastrointestinal malignancy and other solid malignancies.

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Multidetector computed tomography evaluation of synchronous lymphoma and other solid malignancies

Cited by 3 publications

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Multi-detector computed tomography evaluation of synchronous hepatocellular carcinoma and other solid malignancies

Multi-detector computed tomography evaluation of synchronous hepatocellular carcinoma and other solid malignancies

Different situations of identifying second primary malignant tumors in lymphoma patients with synchronous solid tumors

MDCT diagnosis of synchronous primary gastrointestinal tract carcinoma and other solid malignancies: case series study

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