Multidiagnostic evaluation of prolactin response to haloperidol challenge in schizophrenia: Maximal blunting in Kraepelinian patients

Keks, Nicholas A; McKenzie, Dean Philip; Low, Lee Hun; McGorry, Patrick D.; Hill, Christine; Kulkarni, Jayashri; Singh, Bruce; Copolov, David L.

doi:10.1016/0006-3223(92)90130-r

Cited by 23 publications

(14 citation statements)

References 34 publications

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“…Likewise, negative correlations have been reported between prolactin response and severity of delusions 52 . Decreased prolactin responses have been associated with a "Kraepelinian" diagnosis of schizophrenia 53 . Conversely, another study found an association between lower basal prolactin levels and positive symptoms 54 , which is consistent with the results of other studies 34,35 .…”

Section: Discussionmentioning

confidence: 99%

“…The interpretation of these findings is complicated by many potential mechanisms that may be involved. The blunting prolactin response to dopamine antagonists 53,55,56 may indicate dopamine receptor supersensitivity. The worsening of positive symptoms 57 associated with a blunted response to serotonergic challenge may involve reduced serotonin receptor sensitivity.…”

Section: Discussionmentioning

confidence: 99%

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Relationship Between Plasma Levels of Prolactin and the Severity of Negative Symptoms in Patients with Schizophrenia

Ateş

Tutuncu

Oner

et al. 2015

Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychophar

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Relationship between plasma levels of prolactin and the severity of negative symptoms in patients with schizophrenia Objective: The aim of this study was to evaluate the relationship between plasma levels of prolactin and negative symptoms. Methods: One hundred fourteen patients with schizophrenia were included in this crosssectional study. The patients were classified into groups with and without hyperprolactinemia. Plasma levels of prolactin and clinical features were compared between these groups. Results: Negative symptom scores in the group with hyperprolactinemia were significantly higher than in the non-hyperprolactinemic group. There was also a positive correlation between plasma levels of prolactin and negative symptom scores. However, there was no statistically significant difference between schizophrenia subtypes with regard to plasma prolactin levels. Patients treated with conventional neuroleptics or novel antipsychotics such as risperidone, paliperidone and amisulpride had higher prolactin levels than patients treated with aripiprazole, olanzapine, quetiapine, ziprasidone, and clozapine. Conclusion: This study indicated that we should be aware of prolactin levels, especially when negative symptoms are prominent in patients with schizophrenia. Plasma levels of prolactin could be an important biological marker for the severity of negative symptoms in the treatment of patients with schizophrenia. Thus, this finding may change the present pharmacotherapy for negative symptoms in schizophrenia based on prolactin levels.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Relationship Between Plasma Levels of Prolactin and the Severity of Negative Symptoms in Patients with Schizophrenia

Ateş

Tutuncu

Oner

et al. 2015

Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychophar

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“…Negative correlations have been reported between prolactin response and inattention [28] as well as the severity of delusions [29]. Blunted prolactin responses have been associated with a “Kraepelinian” diagnosis of schizophrenia [17] and with schizophreniform disorder [20] in particular. A greater prolactin response to fenfluramine was associated with treatment resistance in one study [30].…”

Section: Challenge and Provocative Test-based Studiesmentioning

confidence: 99%

Prolactin and Psychopathology in Schizophrenia: A Literature Review and Reappraisal

Rajkumar

2014

Schizophrenia Research and Treatment

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Secretion of the anterior pituitary hormone prolactin can be significantly increased by antipsychotic drugs, leading to a range of adverse effects in patients with schizophrenia. However, there is evidence from a variety of studies that prolactin may also be related to symptom profile and treatment response in these patients, and recent work has identified variations in prolactin secretion even in drug-free patients. In this paper, a selective review of all relevant studies pertaining to prolactin and schizophrenia, including challenge and provocation studies, is presented. The implications of this work are discussed critically. A tentative model, which synthesizes these findings and argues for a significant role for prolactin in the development of schizophrenia, is outlined.

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“…An alternative and much less costly approach to research for markers of dopamine dysfunction in schizophrenia relates to the investigation of plasma or cerebrospinal fluid metabolites of dopamine [24] or neuroendocrine markers of hypothalamic pituitary dopaminergic function [25,26]. Although the studies in these areas have reported differences between subjects with schizophrenia and controls, none of the approaches has resulted in findings that are strong and consistent enough to warrant their application as likely biological markers.…”

Section: Dopaminergic Neurotransmissionmentioning

confidence: 99%

Biological markers and schizophrenia

Copolov¹,

Crook²

2000

Aust N Z J Psychiatry

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Multidiagnostic evaluation of prolactin response to haloperidol challenge in schizophrenia: Maximal blunting in Kraepelinian patients

Cited by 23 publications

References 34 publications

Relationship Between Plasma Levels of Prolactin and the Severity of Negative Symptoms in Patients with Schizophrenia

Relationship Between Plasma Levels of Prolactin and the Severity of Negative Symptoms in Patients with Schizophrenia

Prolactin and Psychopathology in Schizophrenia: A Literature Review and Reappraisal

Biological markers and schizophrenia

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