2021
DOI: 10.2147/ijgm.s337876
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Multidimensional Analysis of the Role of Charged Multivesicular Body Protein 7 in Pan-Cancer

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Cited by 10 publications
(8 citation statements)
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“…Charged multivesicular body protein 7 (CHMP7) forms a complex with ESCRT III in the ESCRT system, and initiates the degradation of cell surface receptors ( 40 , 41 ). In addition, CHMP7 is highly expressed in certain hematological malignancies, which is consistent with our research ( 42 ). Cytochrome c somatic (CYCS) is associated with mitochondrial dysfunction and autophagy defects, and it also has potential mechanism in tumor cell proliferation and apoptosis ( 43 , 44 ).…”
Section: Discussionsupporting
confidence: 92%
“…Charged multivesicular body protein 7 (CHMP7) forms a complex with ESCRT III in the ESCRT system, and initiates the degradation of cell surface receptors ( 40 , 41 ). In addition, CHMP7 is highly expressed in certain hematological malignancies, which is consistent with our research ( 42 ). Cytochrome c somatic (CYCS) is associated with mitochondrial dysfunction and autophagy defects, and it also has potential mechanism in tumor cell proliferation and apoptosis ( 43 , 44 ).…”
Section: Discussionsupporting
confidence: 92%
“…40 According to a study, CHMP7 interacts with invading immune cells in the tumor microenvironment and has reduced expression in a variety of tumors compared to normal tissue, which may be a factor in cancer patients' poor prognoses. 41 A member of the GSDM family, GSDMB, can induce pyroptosis by being cleaved by caspase-1/3/4/5/6/7/11; however, further research is needed to determine the precise mechanism by which GSDMB is cleaved by caspase-3/6/7 and engaged in pyroptosis. 15,16,42 According to previous studies, GSDMB is located in genomic regions that are frequently amplified during cancer development and is highly expressed in a variety of cancer tissues, such as cervical, gastric, pancreatic and breast cancers, amongst others.…”
Section: Discussionmentioning
confidence: 99%
“…Contraction, shearing necking and ultimate membrane shedding can all be accomplished with the help of CHMP7, which is essential for the endosomal sorting pathway 40 . According to a study, CHMP7 interacts with invading immune cells in the tumor microenvironment and has reduced expression in a variety of tumors compared to normal tissue, which may be a factor in cancer patients' poor prognoses 41 . A member of the GSDM family, GSDMB, can induce pyroptosis by being cleaved by caspase‐1/3/4/5/6/7/11; however, further research is needed to determine the precise mechanism by which GSDMB is cleaved by caspase‐3/6/7 and engaged in pyroptosis 15,16,42 .…”
Section: Discussionmentioning
confidence: 99%
“…MAPK9 belongs to the MAPK pathway, it has been reported that genetic variation in the MAPK signaling pathway genes can mediate cell proliferation and migration of colorectal cancer cells ( Schwartsmann et al, 2005 ). CHMP7 plays a significant role in the endosomal sorting pathway, and the deficient expression of CHMP7 in the majority of tumor tissues has been reported ( Guo Y. et al, 2021 ). However, the role of CHMP2B, BID and CHMP6 in colorectal cancer have not been reported yet, which may provide new biomarkers for future research on the relationship between necrosis and colorectal cancer.…”
Section: Discussionmentioning
confidence: 99%