The relationship of locus of control to depression, anxiety, hostility, and physical health was assessed in a sample of multicultural college students (N = 162). Powerful Others Health Locus of Control was correlated with depression, anxiety, hostility, and recent physical symptoms while Chance Health Locus of Control (CHLC) was correlated with all of the above as well as chronic physical symptoms and major health problems. When controlling for ~ variety of health risk factors (viz., age, sex, body mass, exercise, smoking, salt, alcohol, and caffeine), only CHLC remained significant in the physical health models. Results support the cognitive model of mental health which emphasize the importance of adaptive beliefs. Specifically, they suggest that issues about control are related to negative affect and indicate that the often-cited relationship of an external locus of control to depression and anxiety also holds for hostility. The findings do not, however, support the view that anxiety and depression are associated with different types of external locus of control but rather suggest a unified set of locus of control beliefs underlying the three types of negative affect. In addition, evidence is provided for the external validity of the Multidimensional Health Locus of Control (MHLC) Scales with respect to mental health. Further, the results indicate that belief about one's health may play a significant role in one's physical health and that the health behavior model of the relationship between locus of control and physical health is insufficient to explain the relationship. As the Chance and Powerful Others MHLC scales were not related to health habits in this sample but were related to mental health (viz., depression, anxiety, and hostility), locus of control beliefs may be related to physical health via their relationship with mental health.According to social learning theory (Rotter, 1966), the potential for a behavior to occur in a given situation is the function of expectancy that the behavior will lead to a reinforcement and the value of that reinforcement to the individual. The basic principle underlying the concept of locus of control derives from social learning theory and argues that reinforcement may be perceived as either contingent upon one's behavior (an internal locus of control) or as independent of one's behavior (an external locus of control).A considerable body of literature utilizing Rotter's (1966) I-E Scale has examined the relationship between locus of control and mental health (particularly depression and anxiety). Abramowitz (1969) was one of the first to demonstrate a positive relationship between an external locus of control and depression. Subsequently, a large number of studies in this area were carried out that almost unequivocally supported the external locus of control-depression connection (e.g., Kumchy, 1981;Morris, 1981;Costello, 1982). Research on the role of "learned helplessness" in depression provides