Multidimensional Risk Factors of Age-Related Hearing Loss Among Malaysian Community‐Dwelling Older Adults

Ooi, Theng Choon; Ishak, Wan Syafira; Sharif, Razinah; Shahar, Suzana; Rajab, Nor Fadilah; Singh, Devinder Kaur Ajit; Mukari, Siti Zamratol-Mai Sarah

doi:10.2147/cia.s340432

Cited by 6 publications

(4 citation statements)

References 47 publications

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“…As previously discussed, several comorbidities, such as obesity and cardiovascular diseases, may accelerate hearing loss by disrupting blood flow in the inner ear [94,95]. Gopinath et al reported that high glucose and total carbohydrate diets among older adults were associated with an increased risk of developing hearing loss [61,96].…”

Section: Low Sugar and Caloric Restriction Dietmentioning

confidence: 99%

Effects of Diet and Lifestyle on Audio-Vestibular Dysfunction in the Elderly: A Literature Review

Chen

Tan

et al. 2022

Nutrients

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Background: The world’s age-related health concerns continue to rise. Audio-vestibular disorders, such as hearing loss, tinnitus, and vertigo, are common complaints in the elderly and are associated with social and public health burdens. Various preventative measures can ease their impact, including healthy food consumption, nutritional supplementation, and lifestyle modification. We aim to provide a comprehensive summary of current possible strategies for preventing the age-related audio-vestibular dysfunction. Methods: A PubMed, Embase, and Cochrane review databases search was conducted to identify the relationship between diet, lifestyle, and audio-vestibular dysfunction. “Diet,” “nutritional supplement,” “lifestyle,” “exercise,” “physical activity,” “tinnitus,” “vertigo” and “age-related hearing loss” were used as keywords. Results: Audio-vestibular dysfunction develops and progresses as a result of age-related inflammation and oxidative stress. Diets with anti-inflammatory and antioxidant effects have been proposed to alleviate this illness. A high-fat diet may induce oxidative stress and low protein intake is associated with hearing discomfort in the elderly. Increased carbohydrate and sugar intake positively correlate with the incidence of audio-vestibular dysfunction, whereas a Mediterranean-style diet can protect against the disease. Antioxidants in the form of vitamins A, C, and E; physical activity; good sleep quality; smoking cessation; moderate alcohol consumption; and avoiding noise exposure are also beneficial. Conclusions: Adequate diet or nutritional interventions with lifestyle modification may protect against developing audio-vestibular dysfunction in elderly individuals.

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Section: Low Sugar and Caloric Restriction Dietmentioning

confidence: 99%

Effects of Diet and Lifestyle on Audio-Vestibular Dysfunction in the Elderly: A Literature Review

Chen

Tan

et al. 2022

Nutrients

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“…Fasted venous blood (overnight fasting of at least 8 h) was collected from each participant by a trained phlebotomist, as described previously [12]. Then, the blood samples were sent to an accredited clinical diagnostic laboratory for biochemical analysis.…”

Section: Blood Samples Collection and Biochemical Analysismentioning

confidence: 99%

Predictors, Protective Factors, and Adverse Outcomes of Joint Pain among Malaysian Community-Dwelling Older Adults: Findings from the LRGS-TUA Longitudinal Study

Ooi,

Rivan,

Shahar

et al. 2024

JCM

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Background: Joint pain has been recognized as one of the major causes of limitations in mobility, functional decline, and consequently declined quality of life in older adults. Hence, this study aimed to identify the predictors, protective factors, and adverse outcomes of joint pain in community-dwelling older adults. Methods: In this Long-term Research Grant Scheme—Towards Useful Ageing (LRGS-TUA) longitudinal study, a total of 1005 older participants aged 60 years and above who were successfully followed up after five years were included in the analysis. The participants self-reported their joint pain status at baseline and during the fifth year. Subsequently, the baseline characteristics were used to predict changes in joint pain status. Adverse outcomes related to joint pain were evaluated based on the participants’ joint pain statuses. Results: Results showed that being female, having diabetes mellitus, and higher body mass index were associated with the incidence of joint pain. Meanwhile, increased intake of pantothenic acid and higher levels of blood albumin levels were associated with recovery from joint pain. Participants with persistent joint pain at baseline and follow-up showed higher levels of depression and disability compared to individuals who never experience any joint pain. However, participants who had recovered from joint pain did not differ significantly from those without joint pain at baseline and follow-up in these measures. Conclusions: By identifying the modifiable risk factors, factors associated with recovery, and adverse outcomes related to joint pain, this study adds to current evidence that may contribute to further management strategies for joint pain in older adults.

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“…A survey of the Korean population showed that smokers with diabetes had a higher risk of developing ARHL than non-smokers with diabetes [ 67 ]. In the Malaysian population, an increased risk of ARHL was linked to an increased waist circumference, decreased niacin and potassium intake, and increased carbohydrate intake [ 68 ]. Intermittent hypoxic conditions, high-fat diet, and galactose injections accelerate the aging of cochlear HCs in mice [ 69 ].…”

Section: Major Causal Factors Of Arhlmentioning

confidence: 99%

Age-related hearing loss and its potential drug candidates: a systematic review

Hu,

Sun,

et al. 2023

Chin Med

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Background Age-related hearing loss (ARHL) is one of the main illnesses afflicting the aged population and has a significant negative impact on society, economy, and health. However, there is presently no appropriate therapeutic treatment of ARHL due to the absence of comprehensive trials. Objectives The goal of this review is to systematically evaluate and analyze recent statistics on the pathologic classifications, risk factors, treatment strategies, and drug candidates of ARHL, including that from traditional Chinese medicine (TCM), to provide potential new approaches for preventing and treating ARHL. Methods Literature related to ARHL was conducted in databases such as PubMed, WOS, China National Knowledge Infrastructure (CNKI), and Wanfang from the establishment of the database to Jan, 2023. The pathology, causal factor, pathophysiological mechanism, treatment strategy, and the drug candidate of ARHL were extracted and pooled for synthesis. Results Many hypotheses about the etiology of ARHL are based on genetic and environmental elements. Most of the current research on the pathology of ARHL focuses on oxidative damage, mitochondrial dysfunction, inflammation, cochlear blood flow, ion homeostasis, etc. In TCM, herbs belonging to the kidney, lung, and liver meridians exhibit good hearing protection. Seven herbs belonging to the kidney meridian, 9 belonging to the lung meridian, and 4 belonging to the liver meridian were ultimately retrieved in this review, such as Polygonum multiflorum Thunb., Panax ginseng C.A. Mey, and Pueraria lobata (Willd.) Ohwi. Their active compounds, 2,3,4',5-Tetrahydroxystilbene-2-O-D-glucoside, ginsenoside Rb1, and puerarin, may act as the molecular substance for their anti-ARHL efficacy, and show anti-oxidative, neuroprotective, anti-inflammatory, anti-apoptotic, or mitochondrial protective effects. Conclusion Anti-oxidants, modulators of mitochondrial function, anti-inflammation agents, vasodilators, K+ channel openers, Ca2+ channel blockers, JNK inhibitors, and nerve growth factors/neurotrophic factors all contribute to hearing protection, and herbs are an important source of potential anti-ARHL drugs.

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Multidimensional Risk Factors of Age-Related Hearing Loss Among Malaysian Community‐Dwelling Older Adults

Cited by 6 publications

References 47 publications

Effects of Diet and Lifestyle on Audio-Vestibular Dysfunction in the Elderly: A Literature Review

Effects of Diet and Lifestyle on Audio-Vestibular Dysfunction in the Elderly: A Literature Review

Predictors, Protective Factors, and Adverse Outcomes of Joint Pain among Malaysian Community-Dwelling Older Adults: Findings from the LRGS-TUA Longitudinal Study

Age-related hearing loss and its potential drug candidates: a systematic review

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