Multidimensionale diffusionsgewichtete Magnetresonanztomographie

Laun, Frederik Bernd

doi:10.1016/j.zemedi.2019.11.002

Zeitschrift für Medizinische Physik

2020

DOI: 10.1016/j.zemedi.2019.11.002

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Multidimensionale diffusionsgewichtete Magnetresonanztomographie

Frederik Bernd Laun¹

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2021

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Cited by 2 publications

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“…NMR and MRI exploit the interaction of nuclear spins with magnetic field to analyze chemical structures, reaction kinetics, and biological tissue. Given the rich portfolio of magnetic resonance (MR) methods to interrogate these properties, MR has become indispensable in chemistry, [1,2] medical diagnostics, [3][4][5][6] and related fields. [7,8] However, most of these methods effectively use only a small fraction of all available spins: the equilibrium thermal polarization of 1 H is about 3 ppm per Tesla at room temperature.…”

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confidence: 99%

Frequency‐Selective Manipulations of Spins allow Effective and Robust Transfer of Spin Order from Parahydrogen to Heteronuclei in Weakly‐Coupled Spin Systems

2021

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We present a selectively pulsed (SP) generation of sequences to transfer the spin order of parahydrogen (pH2) to heteronuclei in weakly coupled spin systems. We analyze and discuss the mechanism and efficiency of SP spin order transfer (SOT) and derive sequence parameters. These new sequences are most promising for the hyperpolarization of molecules at high magnetic fields. SP‐SOT is effective and robust despite the symmetry of the 1H‐13C J‐couplings even when precursor molecules are not completely labeled with deuterium. As only one broadband 1H pulse is needed per sequence, which can be replaced for instance by a frequency‐modulated pulse, lower radiofrequency (RF) power is required. This development will be useful to hyperpolarize (new) agents and to perform the hyperpolarization within the bore of an MRI system, where the limited RF power has been a persistent problem.

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confidence: 99%

Frequency‐Selective Manipulations of Spins allow Effective and Robust Transfer of Spin Order from Parahydrogen to Heteronuclei in Weakly‐Coupled Spin Systems

2021

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Effects of deep inspiration breath hold on prone photon or proton irradiation of breast and regional lymph nodes

Speleers

Schoepen

Belosi

et al. 2021

Sci Rep

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We report on a comparative dosimetrical study between deep inspiration breath hold (DIBH) and shallow breathing (SB) in prone crawl position for photon and proton radiotherapy of whole breast (WB) and locoregional lymph node regions, including the internal mammary chain (LN_MI). We investigate the dosimetrical effects of DIBH in prone crawl position on organs-at-risk for both photon and proton plans. For each modality, we further estimate the effects of lung and heart doses on the mortality risks of different risk profiles of patients. Thirty-one patients with invasive carcinoma of the left breast and pathologically confirmed positive lymph node status were included in this study. DIBH significantly decreased dose to heart for photon and proton radiotherapy. DIBH also decreased lung doses for photons, while increased lung doses were observed using protons because the retracting heart is displaced by low-density lung tissue. For other organs-at-risk, DIBH resulted in significant dose reductions using photons while minor differences in dose deposition between DIBH and SB were observed using protons. In patients with high risks for cardiac and lung cancer mortality, average thirty-year mortality rates from radiotherapy-related cardiac injury and lung cancer were estimated at 3.12% (photon DIBH), 4.03% (photon SB), 1.80% (proton DIBH) and 1.66% (proton SB). The radiation-related mortality risk could not outweigh the ~ 8% disease-specific survival benefit of WB + LN_MI radiotherapy in any of the assessed treatments.

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Multidimensionale diffusionsgewichtete Magnetresonanztomographie

Cited by 2 publications

References 10 publications

Frequency‐Selective Manipulations of Spins allow Effective and Robust Transfer of Spin Order from Parahydrogen to Heteronuclei in Weakly‐Coupled Spin Systems

Frequency‐Selective Manipulations of Spins allow Effective and Robust Transfer of Spin Order from Parahydrogen to Heteronuclei in Weakly‐Coupled Spin Systems

Effects of deep inspiration breath hold on prone photon or proton irradiation of breast and regional lymph nodes

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