Multidisciplinary Approach in the Early Detection of Undiagnosed Connective Tissue Diseases in Patients With Interstitial Lung Disease: A Retrospective Cohort Study

Tirelli, Claudio; Morandi, Valentina; Valentini, Adele; Carrubba, Claudia La; Dore, Roberto; Zanframundo, Giovanni; Morbini, Patrizia; Grignaschi, Silvia; Franconeri, Andrea; Oggionni, Tiberio; Marasco, Emiliano; Stefano, Ludovico De; Kadija, Zamir; Mariani, Francesca; Codullo, Veronica; Alpini, Claudia; Scirè, Carlo Alberto; Montecucco, Carlomaurizio; Meloni, Federica; Cavagna, Lorenzo

doi:10.3389/fmed.2020.00011

Cited by 24 publications

(23 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These serological data are consistent with previous reports that showed a higher frequency of ILD in anti-Jo-1 negative anti-synthetase syndrome patients [47][48][49]. As previously reported, patients from our series with diagnosis of IPAF presented high positivity of ANA antibodies [32,37].…”

Section: Ra-ild N (%)supporting

confidence: 93%

See 1 more Smart Citation

The Spectrum of Interstitial Lung Disease Associated with Autoimmune Diseases: Data of a 3.6-Year Prospective Study from a Referral Center of Interstitial Lung Disease and Lung Transplantation †

Atienza‐Mateo

Remuzgo‐Martínez

Cuesta

et al. 2020

JCM

View full text Add to dashboard Cite

Interstitial lung disease (ILD) may occur in patients with a rheumatic autoimmune disease (AD), increasing their risk of morbidity and mortality. However, little is known about the prevalence of AD in patients diagnosed with an ILD. In this prospective study, we determined the spectrum of ILD associated with AD (AD-ILD) among patients sent for assessment to a single clinic of ILD and lung transplantation from a referral center between May 2016 and December 2019. ILD diagnosis was made by pneumologists based on clinical and radiological findings and pulmonary function test abnormalities. All patients with ILD were also assessed by experienced rheumatologists. During the period of assessment, 338 patients were diagnosed with ILD. Among them, 32.8% fulfilled definitions for an AD. Most cases with AD-ILD had a diagnosis of rheumatoid arthritis (27.0%), systemic sclerosis (26.1%) or anti-synthetase syndrome (17.1%). Interestingly, 18% of the patients with AD-ILD were diagnosed as having an interstitial pneumonia with autoimmune features. Antinuclear antibodies and non-specific interstitial pneumonia were the most frequent positive autoantibodies and radiological pattern found in AD-ILD patients, respectively. In conclusion, our study indicates that a high number of ILD patients have a related AD. Consequently, close collaboration among rheumatologists and pneumologists is needed.

show abstract

Section: Ra-ild N (%)supporting

confidence: 93%

“…In this regard, there is great concern among pneumologists and rheumatologists about the need to establish early recognition and management of a related autoimmune pathology in patients referred for an ILD. However, the confirmation of an ILD diagnosis associated with an AD requires a highly qualified multidisciplinary team [21,32].…”

Section: Discussionmentioning

confidence: 99%

The Spectrum of Interstitial Lung Disease Associated with Autoimmune Diseases: Data of a 3.6-Year Prospective Study from a Referral Center of Interstitial Lung Disease and Lung Transplantation †

Atienza‐Mateo

Remuzgo‐Martínez

Cuesta

et al. 2020

JCM

View full text Add to dashboard Cite

show abstract

“…The prevalence of former or current smoking history in patients with IPAF was 38.8% to 56.2% [7,11,16,17]. The most common morphological pattern is NSIP in IPAF, with a prevalence of 42.1% to 68.9% [7,8,10,11,[13][14][15]17,18]. However,…”

Section: Epidemiology and Prevalence Of The Clinical Serological Anmentioning

confidence: 98%

“…A c c e p t e d A r t i c l ecapillaroscopy could improve the differentiation between IPAF, ARD-ILD, and idiopathic ILD[18]. Several parameters can be observed in nailfold capillaroscopy for patients with SSc, including 1) irregularly enlarged capillaries, 2) giant capillaries, 3) hemorrhage, 4) loss of capillaries (avascular area), 5) disorganization of the vascular array, and 6) capillary ramifications[46].…”

mentioning

confidence: 99%

Recent advances in the diagnosis and management of interstitial pneumonia with autoimmune features: the perspective of rheumatologists

Min

Kim

Lee

et al. 2021

Korean J Intern Med

View full text Add to dashboard Cite

Interstitial pneumonia with autoimmune features (IPAF) is a recently established disease entity that is comprised of interstitial lung diseases with evidence of autoimmune features but does not fulfill the criteria for definite autoimmune rheumatic disease. The classification criteria for IPAF were defined by the European Respiratory Society and American Thoracic Society in 2015. However, for these classification criteria, further studies to establish IPAF subgroups and treatment modalities for each subgroup are still needed. In this review, we discuss the recent advances in the field of IPAF and raise critical points for the diagnosis and management of patients with IPAF from the perspective of rheumatologists.

show abstract

“…Therapy with prednisone (2.5 mg/day) and hydroxychloroquine (400 mg/day) was initially confirmed. The case was discussed in the Pavia Multidisciplinary Group for Interstitial Lung Disease which involves Pulmonologists, Rheumatologists, Radiologists, and Pathologists [4] . HRCT was reviewed by 2 thoracic radiologists who suspected nodular amyloidosis, a condition associated with SS in 6% of cases [1 , 5] .…”

Section: Case Presentationmentioning

confidence: 99%

CT-guided biopsy in the differential diagnosis of Sjogren syndrome associated cystic lung disease: A case of lung nodular AL-k amyloidosis

Tirelli

Zanframundo

Valentini

et al. 2020

Radiology Case Reports

Self Cite

View full text Add to dashboard Cite

Pulmonary involvement in Sjogren syndrome (SS) could manifest as cystic lung disease (CLD). CLD in SS includes lymphocytic interstitial pneumonia (LIP) and pulmonary amyloidosis. Differential diagnosis usually requires surgical lung biopsy, whereas CT-guided percutaneous fine needle aspiration biopsy (CT-FNAB) has not yet explored. We describe the case of a 63-year-old never smoker Caucasian female with a SS diagnosis who displayed a newly detected diffuse CLD at high-resolution computed tomography, though totally asymptomatic. Given the favorable location of one big lesion at the superior left lobe, a CT-FNAB was proposed instead of a more invasive SLB. At histology examination a diagnosis of pulmonary nodular AL kappa amyloidosis in the context of SS was established. In conclusion, CT-FNAB might represent an alternative and less invasive diagnostic procedure than SLB in the differential diagnosis of CLD, even if further research is needed. Moreover, this case presents an unusual association between SS and pulmonary nodular AL kappa amyloidosis, with pulmonary nodules and cysts without systemic manifestations.

show abstract

Multidisciplinary Approach in the Early Detection of Undiagnosed Connective Tissue Diseases in Patients With Interstitial Lung Disease: A Retrospective Cohort Study

Cited by 24 publications

References 56 publications

The Spectrum of Interstitial Lung Disease Associated with Autoimmune Diseases: Data of a 3.6-Year Prospective Study from a Referral Center of Interstitial Lung Disease and Lung Transplantation †

The Spectrum of Interstitial Lung Disease Associated with Autoimmune Diseases: Data of a 3.6-Year Prospective Study from a Referral Center of Interstitial Lung Disease and Lung Transplantation †

Recent advances in the diagnosis and management of interstitial pneumonia with autoimmune features: the perspective of rheumatologists

CT-guided biopsy in the differential diagnosis of Sjogren syndrome associated cystic lung disease: A case of lung nodular AL-k amyloidosis

Contact Info

Product

Resources

About