Multidisciplinary approach to management of hypofibrinogenaemia in pregnancy: A case report

Abstract

Inherited fibrinogen disorders introduce risk for recurrent abortions, sub-chorionic haematoma, placental abruption and postpartum haemorrhage. This is a case report of a successful pregnancy outcome in a 37-year old woman with hypofibrinogenaemia. She was referred to a coagulation test in the first trimester because of history of preeclampsia and HELLP syndrome in previous pregnancy. Hypofibrinogenaemia was diagnosed with fibrinogen level of 0.7 g/L. During the pregnancy she was regularly monitored for fibrinogen levels and multiple cryoprecipitate concentrates were given. She delivered at 39th gestation week, with elective caesarean section under general anaesthesia. There was one episode of postpartum haemorrhage treated with 2 units of red blood cells, repeated infusions of cryoprecipitate to obtain the level of fibrinogen of 2 g/L. She was discharged on the 6th postpartum day in a good condition. In these disorders levels of fibrinogen should be higher than 1 g/L during pregnancy or 2 g/L in case of caesarean section for successful prenatal and peripartal management.

COVID-19 pandemic, passing of professor Folke Sjöqvist and other topics

“…Since our journal covers all fields of medicine, the remaining articles bring the results of some basic pharmacological experiments on the role of GABA A receptors in vasodilation, 10 on the role of clinical pathways in quality improvement in patients undergoing total hip replacement 11 and describe some clinical studies performed in the fields of ophthalmology 12 and hepatic resections in metastatic colorectal cancer surgery, 13 followed by a case report on hypofibrinogenaemia in pregnancy. 14 Of course, the Editorial Board will continue to follow the COVID-19 pandemic as it evolves, but at the same time will try to provide to its readers coverage of all other interesting topics.…”