Multidisciplinary Design Optimization (MDO) has been used to investigate the use of a new concept for a transonic transport, the strut-braced wing. The incorporation of a strut into more traditional transonic transport concepts required the application of computational design techniques that had been developed at Virginia Tech over the previous decade. Formalized MDO methods were required to reveal the benefits of the tightly coupled interaction between the wing structural weight and the aerodynamic performance. To perform this study, a suite of approximate analysis tools was assembled into a complete, conceptual-level MDO code. A typical mission of the Boeing 777-200IGW was chosen as the design mission profile. Several single-strut configurations were optimized for minimum takeoff gross weight, with the best single-strut configuration showing a nearly20% reduction in takeoff gross weight, a 29% reduction in fuel weight, a 28% increase in the lift-to-drag ratio, and a 41% increase in seat-miles per gallon relative to a comparable cantilever configuration. The use of aeroelastic tailoring in the design illustrated ways to obtain further benefits. The paper synthesizes the results of the five-year effort, and concludes with a discussion of the effects various constraints have on the design, and lessons learned on computational design during the project.