Multidisciplinary interventions in the management of atopic dermatitis

LeBovidge, Jennifer; Elverson, Wendy; Timmons, Karol; Hawryluk, Elena B.; Rea, Corinna J.; Lee, Margaret; Schneider, Lynda C.

doi:10.1016/j.jaci.2016.04.003

Cited by 81 publications

(78 citation statements)

References 94 publications

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“…[29,30] This is important, because these kinds of emotional experiences can impair concentration during class; in fact, students with severe AD are often absent from school. [31,32] Such factors ultimately have a negative effect on education and can lead to children becoming withdrawn [33] ; it may also increase the likelihood that they will exhibit difficult behavior or even lead to the development of pediatric and adolescent psychiatric disorders. [7,13,26] Thus, the cosmetic discomfort of AD is significantly related to mental health.…”

Section: Discussionmentioning

confidence: 99%

Psychiatry outpatient visits by atopic dermatitis patients varying in the complexity of their prescriptions

Shin¹,

Choi²,

Park³

et al. 2016

Medicine

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Section: Discussionmentioning

confidence: 99%

Psychiatry outpatient visits by atopic dermatitis patients varying in the complexity of their prescriptions

Shin¹,

Choi²,

Park³

et al. 2016

Medicine

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“…The effect of verbal suggestion on itch can be similarly explored in the same way as VEI by written or audio delivery of itch-evoking stimuli to explore the mechanisms of socially transferred itch and whether patients with chronic itch may have altered cognitive schemas that make them more prone to contagious itch versus the general population, as a consequence of suffering from long-term itch. VEIbased paradigms could also be used to evaluate AD itch-scratch triggers (eg, irritants, environmental allergens, food, and contact allergens) within a multidisciplinary intervention approach [24] . The use of such adjunctive psychological interventions that target the habitual scratching may be of help to reduce and attenuate the itchscratch cycle in particular in patients with chronic itch [25] .…”

Section: Discussionmentioning

confidence: 99%

Are sex and history of pruritic skin conditions factors which affect the phenomenon of visually evoked itch? An exploratory study

Lloyd¹,

Dodd²,

Higgins³

et al. 2017

Itch

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Introduction:We have previously shown that sensations of itch and the scratch response can be evoked using itch-related images. However, we did not determine whether individual differences in a person's experience of itch could moderate this effect. This exploratory study aimed to determine whether sex or a history of pruritic skin conditions (PSCs) could influence the effects of visually evoked itch and scratch. Methods: Forty-one participants (19 males; 16 with a history of PSCs) viewed static images that could either be itch or nonitch related. These were further separated by picture type: "skin contact" (ants crawling on the hand vs. a butterfly on the finger); "skin response" (scratching an insect bite vs. washing the hands); "skin condition" (psoriasis vs. freckles) or "context only" (insects vs. birds). Images were rated using a 10-point scale by answering: "How itchy do you feel?" (Self-rating) and "How itchy do you think the person in the picture feels?" (Other-rating). Frequency and location of scratching was also recorded. Results: The highest itch scores were to itch-related skin contact pictures. Females gave higher itch ratings than males, and people with a history of PSCs gave higher itch ratings when viewing images of people scratching. There was no correlation between itch ratings and scratch response, and no relationship between body site viewed and location of scratching. Discussion: There is a heightened response to itch-related cues in females and those with PSCs, indicating a more centrally mediated pathway bringing subconscious itch sensations into conscious awareness in these populations. These findings could influence personalized treatment interventions aimed at reducing awareness of itch sensations in susceptible individuals.

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“…Although the majority of childhood AD spontaneously resolves by adulthood, the disease persists in 10% to 30% of cases . More rarely, the first symptoms develop in adulthood, and the prevalence of AD in adults is approximately 1% to 3% . AD histology consists of epidermal hyperplasia (acanthosis) with inflammatory cell infiltration, including T cells and dendritic cells (DCs), in the superficial dermis.…”

Section: Overview Of Atopic Dermatitis (Ad)mentioning

confidence: 99%

The interplay between genetic and environmental factors in the pathogenesis of atopic dermatitis

Otsuka

Nomura

Rerknimitr

et al. 2017

Immunological Reviews

134

105

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Atopic dermatitis (AD) is a chronic skin disorder characterized by pruritus and recurrent eczematous lesions that are accompanied by T-helper (Th)2-dominated inflammation. AD Etiology is not yet completely understood, but it is multifactorial. Moreover, the disease is characterized by complex interactions between genetic and environmental factors, such as skin barrier dysfunctions, allergy/immunity, and pruritus. For example, filaggrin is a key protein involved in skin barrier function. Th2 cells produce interleukin (IL)-31, which provokes pruritus, and other Th2 cytokines decrease filaggrin expression by keratinocytes. Dupilumab has recently been developed for AD treatment; its mechanism of action is to bind to IL-4 receptor α and inhibit downstream signaling induced by IL-4 and IL-13. This review summarizes the etiopathogenesis of AD and provides the rationale for selecting a novel targeted therapy.

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Multidisciplinary interventions in the management of atopic dermatitis

Cited by 81 publications

References 94 publications

Psychiatry outpatient visits by atopic dermatitis patients varying in the complexity of their prescriptions

Psychiatry outpatient visits by atopic dermatitis patients varying in the complexity of their prescriptions

Are sex and history of pruritic skin conditions factors which affect the phenomenon of visually evoked itch? An exploratory study

The interplay between genetic and environmental factors in the pathogenesis of atopic dermatitis

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