Multidisciplinary management of cleidocranial dysplasia

Chalala, Chimène; Noujeim, Ziad; Chebel, Naji Abou; Saadé, Antoine

doi:10.1016/j.ejwf.2014.10.002

Cited by 4 publications

(7 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, the relative or absolute activity of the temporalis muscle can accelerate the occurrence of CPH. Importantly, related literature and our clinical data show that Shprintzen-Goldberg syndrome is associated with the SKI gene and the FBN1 gene, whereas Loeys-Dietz syndrome with mutations in the TGFB gene, cleidocranial dysplasia syndrome with mutations in the RUNX2 gene (Chalala et al, 2015;Tang et al, 2007), and Munchmeyer's disease with mutations in SMAD 2/3 signaling (Bhansali et al, 2021;de Ruiter et al, 2021;Duan et al, 2010;Eekhoff et al, 2018;Okuno et al, 2017;Towler et al, 2020).…”

Section: Discussionsupporting

confidence: 52%

“…Cleidocranial dysplasia syndrome (OMIM 119600) is mainly an autosomal‐dominant disease associated with mutations in the RUNX2 gene, which plays an important role in regulating bone metabolism (Jaruga et al, 2016). Cleidocranial dysplasia syndrome is characterized by hypoplasia or complete absence or reduction in the size of the clavicle, zygomatic arch hypoplasia, micromaxillary deformity, maxillary hypoplasia leading to impaired eruption of permanent teeth (often with multiple teeth), and narrowing of the ascending branches of the mandible (Chalala et al, 2015). Chalala et al (2015) reported an 18‐year‐old female patient with cleidocranial dysplasia syndrome who had an unusually elongated and pointed mandibular coronoid process with a distally curved upward‐backward‐pointing coronoid process and no abnormal mouth opening.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Congenital mandibular coronoid process hyperplasia and associated diseases

Wang

2022

Oral Diseases

View full text Add to dashboard Cite

Coronoid process hyperplasia (CPH) is an oral and maxillofacial surgical disease that can result in restricted jaw movement due to an enlarged and elongated mandibular coronoid process. It is characterized by the painless progressive restriction of unilaterally or bilaterally mouth opening. Clinically, unexplained bilateral CPH is less common and therefore often overlooked or misdiagnosed, and coronoidectomy can be very effective on improving mouth opening. Currently, the exact etiology and mechanism of congenital CPH have not yet been fully understood, but it is generally believed to be genetically related. In this paper, the relationship of the congenital mandibular CPH with the related diseases was examined based on cases collected in our clinic and literature review for the clinical diagnosis and treatment of patients with restricted mouth opening associated with CPH.

show abstract

Section: Discussionsupporting

confidence: 52%

Section: Resultsmentioning

confidence: 99%

Congenital mandibular coronoid process hyperplasia and associated diseases

Wang

2022

Oral Diseases

View full text Add to dashboard Cite

show abstract

“…3,38 CCD complications do not present a curative therapy; however, some of the disease conditions can be corrected through multidisciplinary treatment aimed at improving the health, esthetics, and quality of life of patients. 39 Dental complications are usually the main intervened sign, and treatment generally involves exodontic and orthodontic procedures; however, the management of complications is challenging and in the long term that requires careful planning. 3,13 On the other hand, some other surgical procedures to correct cranial bone insufficiency have been performed.…”

Section: Discussionmentioning

confidence: 99%

Clinical‐radiological approach for the diagnosis of cleidocranial dysplasia in adults: A familial cases series

Segovia-Fuentes

Egurrola

Castro‐Mendoza

et al. 2021

Clinical Case Reports

View full text Add to dashboard Cite

show abstract

“…Chromosome 6p21 is responsible for the morphogenesis of the skeleton and also in the differentiation of the specific cells as osteoblasts [14][15][16]. RUNX2 is crucial for the proliferation of specific cells specialized for the synthetization of bone and tooth and also the proliferation of osteoblasts [17][18][19][20]. Runt-domain mutations are related to important dental anomalies such as supernumerary teeth, eruption alteration, etc.…”

Section: Introductionmentioning

confidence: 99%

Genetic Pattern, Orthodontic and Surgical Management of Multiple Supplementary Impacted Teeth in a Rare, Cleidocranial Dysplasia Patient: A Case Report

et al. 2021

View full text Add to dashboard Cite

Background: Cleidocranial dysplasia (CCD) is a rare, autosomal dominant skeletal dysplasia with a prevalence of one per million births. The main causes of CCD are mutations in the core-binding factor alpha-1 (CBFA1) or runt-related transcription factor-2 (RUNX2), located at the 6p21 chromosomal region. RUNX2 plays important roles in osteoblast differentiation, chondrocyte proliferation and differentiation, and tooth formation. The disease is characterized by clavicular aplasia or hypoplasia, Wormian bones, delayed closure of cranial suture, brachycephalic head, maxillary deficiency, retention of primary teeth, inclusion of permanent teeth, and multiple supernumerary teeth. Materials and Methods: A 22-year-old girl suffering from cleidocranial dysplasia with short stature, narrow shoulders, craniofacial manifestations (short face, broad forehead, etc.) and dental anomalies (different lower dental elements under eruption, supernumerary and impacted multiple teeth, etc.) was examined at our service (Complex Operative Unit of Odontostomatology of Policlinico of Bari). RX Orthopantomography (OPG) and cone beam computed tomography (CBCT) were requested to better assess the position of the supernumerary teeth and their relationships with others and to evaluate the bone tissue. Results: Under eruption was probably caused by dental interferences with supernumerary teeth; hence, extractions of supernumerary upper canines and lower premolars were performed under general anaesthesia. Surgery outcome was excellent with good tissue healing and improvements in the therapeutic possibilities with future orthodontics. Conclusions: The objective of this article is to give an update about radiological, clinical, and molecular features of CCD and to alert the health team about the importance of establishing an early diagnosis and an appropriate treatment in these patients to prevent impacted teeth complications and to offer them a better quality of life.

show abstract

Multidisciplinary management of cleidocranial dysplasia

Cited by 4 publications

References 16 publications

Congenital mandibular coronoid process hyperplasia and associated diseases

Congenital mandibular coronoid process hyperplasia and associated diseases

Clinical‐radiological approach for the diagnosis of cleidocranial dysplasia in adults: A familial cases series

Genetic Pattern, Orthodontic and Surgical Management of Multiple Supplementary Impacted Teeth in a Rare, Cleidocranial Dysplasia Patient: A Case Report

Contact Info

Product

Resources

About