Multidisciplinary Management of Soft-Tissue Sarcoma

Robinson, Emma; Bleakney, Robert; Ferguson, Peter C.; O’Sullivan, Brian

doi:10.1148/rg.287085167

Cited by 59 publications

(24 citation statements)

References 52 publications

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“…Laboratory tests and predisposing underlying conditions would differentiate this entity from lymphoma [26]. On MRI, primary soft tissue sarcomas typically present with a distinct rounded mass [27]. Intramuscular metastases appear as enhancing masses with central necrosis and peritumoral edema [28].…”

Section: Discussionmentioning

confidence: 99%

Skeletal Muscle Involvement in B-Cell Lymphoma: Two Cases Illustrating the Contribution of Imaging to a Clinically Unsuspected Diagnosis

Burton

Schafernak

Morgan

et al. 2017

Case Reports in Radiology

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Skeletal muscle lymphoma is rare, comprising only a very small subset of lymphoma cases. There are characteristic imaging features which, if recognized, can prevent delay in diagnosis and treatment, particularly when not suspected clinically. Herein, we report two cases of skeletal muscle lymphoma with nearly identical imaging features; the first is an example of primary muscle lymphoma in a 17-year-old boy with back and thigh pain, and the second represents lymphoma recurrence in a 55-year-old man with HIV. Characteristic features seen on MRI were key in raising suspicion for the disease and helped prevent a delay in pathologic diagnosis.

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Section: Discussionmentioning

confidence: 99%

Skeletal Muscle Involvement in B-Cell Lymphoma: Two Cases Illustrating the Contribution of Imaging to a Clinically Unsuspected Diagnosis

Burton

Schafernak

Morgan

et al. 2017

Case Reports in Radiology

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“…However, the specific characteristics on MRI that describe a soft tissue lesion as malignant [size>5 cm; ill-defined borders; presence of vessel and neural invasion; compartmental extent; invasion of the surrounding tissues; deep location; heterogeneous T1/T2 signal intensity; and surrounding edema [27, 28]] are not present in all cases. A prospective multi-institutional study of 548 untreated soft tissue tumor lesions found a sensitivity of 93%, specificity of 82% and accuracy of 85% of MRI to distinguish benign from malignant lesions [29].…”

Section: Discussionmentioning

confidence: 99%

Assessing the role of 18F-FDG PET and 18F-FDG PET/CT in the diagnosis of soft tissue musculoskeletal malignancies: a systematic review and meta-analysis

Etchebehere

Hobbs

Milton

et al. 2015

Eur J Nucl Med Mol Imaging

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Purpose Twelve years ago a meta-analysis evaluated the diagnostic performance of 18F-FDG PET in assessing musculoskeletal soft tissue lesions (MsSTL). Currently, PET/CT has substituted PET imaging however there has not been any published meta-analysis on the use of PET/CT or a comparison of PET/CT with PET in the diagnosis of MsSTL. Therefore, we conducted a meta-analysis to identify the current diagnostic performance of 18F-FDG PET/CT and determine if there is added value when compared to PET. Patients and Methods A systematic review of English articles using MEDLINE PubMed, the Cochrane Library and EMBASE were searched from 1996 to March 2015. Studies exploring the diagnostic accuracy of 18F-FDG PET/CT (or dedicated PET) compared to histopathology in patients with MsSTL undergoing investigation for malignancy were included. Results Our meta-analysis included 14 articles composed of 755 patients with 757 soft tissue lesions. There were 451 (60%) malignant tumors and 306 benign lesions. The 18F-FDG PET/CT (and dedicated PET) mean sensitivity, specificity, accuracy, positive and negative predictive values for diagnosing MsSTL was 0.96 (0.90, 1.00), 0.77 (0.67, 0.86), 0.88 (0.85, 0.91), 0.86 (0.78, 0.94) and 0.91 (0.83, 0.99), respectively. The posterior mean (95% HPD interval) for the AUC was 0.92 (0.88, 0.96). PET/CT had higher specificity, accuracy and positive predictive value when compared to a dedicated PET (0.85, 0.89 and 0.91 vs 0.71, 0.85 and 0.82, respectively). Conclusions 18F-FDG PET/CT and dedicated PET are both highly accurate in the diagnosis of MsSTL. PET/CT is more accurate, specific and has a higher positive predictive value than PET.

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“…Findings on ultrasound, CT scan and MRI [2, 12 -15] are usually non-specifi c [2] . In recent years, the MRI fi ndings that are characteristic of schwannomas have been described clearly [5] ( • ▶ Fig. 2 ).…”

Section: Postoperative Course and Pathologymentioning

confidence: 98%

“…T 2 -weighted fat-saturated magnetic resonance imaging in the coronal plane revealed low signal in the central part of the lesion due to increased collagen content (arrow) and high intensity in the peripheral area (arrow), producing a target-like appearance(5).…”

mentioning

confidence: 99%