Multidisciplinary panel opinion on the management of bacterial skin infections

Abstract

Eight hot topics regarding the diagnosis and management of bacterial skin infections were selected and reviewed by five experts from different European countries, chosen based on their expertise in microbiology, infectious diseases, and dermatology. As noninfectious skin diseases/conditions such as atopic dermatitis can be complicated by infections, including Acute Bacterial Skin and Skin Structure Infections (ABSSSI), a collaboration between dermatologists and infectious disease specialists can promote a rational approach to diagnosis and a more functional treatment approach, especially for complicated infections. In addition, an important role would be played by microbiologists as they are crucial for the isolation and classification of the bacterial pathogen to guide clinicians toward the most effective antibiotic therapy. Although there are many therapeutic options for the treatment of bacterial skin infections, including those due to methicillin-resistant Staphylococcus aureus, these drugs often require multiple daily administrations leading to patient noncompliance and are associated with gastrointestinal adverse events and drug resistance. With their characteristics of being long-acting, safety and single-dose regimens, long-acting antibiotics, such as dalbavancin and oritavancin, represent an effective alternative that could change the management of these infections with a considerable reduction of hospitalisation costs and risks.

Switchable adhesive films of pullulan loaded with a deep eutectic solvent-curcumin formulation for the photodynamic treatment of drug-resistant skin infections

“…3 a). and at 98% of RH to evaluate their moisture uptake in extreme moisture conditions, since in case of infections, exudates are commonly found [ 46 ] ( Fig. 3 b).…”

Infección De Piel Y Partes Blandas, Tratamiento en Edad Pediátrica

“…El conveniente control del foco debe considerarse el primer escalón como prioridad absoluta para el manejo y tratamiento eficaz. En caso de bacteriemia persistente a pesar de la antibioticoterapia correcta, debe realizarse una búsqueda activa de focos a distancia (31).…”

“…En Argentina, Bouza et al, (31) identificaron microorganismos aislados habituales con frecuencia polimicrobiana, siendo los resaltantes Staphylococcus aureus, Streptococcus pyogenes (Streptococcus β-hemolítico del grupo A de Lancefield, SBHGA), bacilos gramnegativos aeróbicos y bacterias anaerobias. En las infecciones por mordeduras, los microorganismos implicados integran la microbiota habitual de la boca del agresor; siendo polimicrobianas en un 74% de los casos, con predominio de S. aureus, Peptostreptococcus spp, Prevotella spp.…”

“…y Bacteroides spp. Con menor frecuencia aislaron Pasteurella multocida, Francisella tularensis y Eikenella corrodens, lo cual concuerda con las dos primeras bacterias aisladas en los niños del presente estudio (1,31).…”

Frequency of aac (6 �)-le-aph (2 � �) gene and resistance to Aminoglycoside antibiotics in Staphylococcus aureus isolates

“…At present, S. aureus shows resistance to a broad spectrum of antibiotics including Aminoglycosides, Beta Lactams, Tetracyclines, Fluoroquinolones, and Macrolides. Therefore, there is only a limited number of available antibiotics such as Vancomycin and Teicoplanin that can be used as anti-staphylococcal drugs to treat these types of infections [1,2].…”