Multidisciplinary treatment of advanced or recurrent solid pseudopapillary neoplasm of the pancreas: three case reports

Tanoue, Kazuo; Mataki, Yuko; Kurahara, Hiroshi; Idichi, Tetsuya; Kawasaki, Yota; Yamasaki, Yoichi; Kita, Yoshiaki; Hozaka, Yuto; Oi, Hideyuki; Nakajo, Akihiro; Arigami, Takaaki; Maemura, Kosei; Ohtsuka, Takao

doi:10.1186/s40792-022-01358-0

Cited by 22 publications

(16 citation statements)

References 30 publications

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“…In the presented case reports no treatments were offered to the patients. Wojciak et al described a case of lymph node recurrence 1 year after transplantation that was treated with excision, radiotherapy, and switching to mTOR inhibition immunosuppression [4]. Lymph node status was carefully evaluated in our case.…”

Section: Discussionmentioning

confidence: 91%

“…However, 10-15% of cases of SPN have metastatic disease at the time of diagnosis and the most common site is the liver. Tanue et al reported that in patients with malignant feature SPN, liver metastasis occurs in 57.1% of cases [4]. Sperti et al reported occurrence of hepatic metastasis 2-168 months after diagnosis of the primary tumor [11].…”

Section: Discussionmentioning

confidence: 99%

“…The liver is the most common site for metastasis. The optimal treatment for improving survival of metastatic disease is surgical resection [4,5]. Liver transplantation has been reported in a few cases of irresectable liver metastasis.…”

Section: Introductionmentioning

confidence: 99%

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Liver Transplantation for Liver Metastasis of a Pseudopapillary Pancreatic Neoplasm in a Male Patient

et al. 2023

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Unusual clinical course Background:Solid pseudopapillary neoplasm (SPN) of the pancreas, which predominantly affects young women, is an uncommon condition with low malignant potential. It is often asymptomatic. This tumor has a low metastatic rate and a good prognosis in contrast to other pancreatic tumors. Approximately 14% of SPNs develop liver metastasis, but for SPNs with malignant features liver metastasis has been reported to occur in over 55% of cases. Complete surgical resection is the treatment of choice for increasing the survival rate in metastatic recurrent disease. When surgical resection is impossible, liver transplantation has shown promising results in a few cases. The purpose of this article is to present the first case of a male patient who underwent liver transplantation for this indication. Case Report:We present the case of a 60-year-old male patient who previously had pancreas surgery, numerous liver resections, and chemotherapy for SPN, but nevertheless developed recurrence of multiple liver metastases. His metastatic liver disease was regarded as unresectable. The lymphatic structure was also affected. The patient underwent orthotopic liver transplantation with a deceased donor graft after multidisciplinary evaluation. At 2-year follow-up, the patient was alive and recurrence free. Conclusions:This is the first published report of a male patient who underwent liver transplantation due to SPN metastasis. Our case demonstrates that liver transplantation should be further investigated for selected cases of SPN of the pancreas with liver metastatic disease when surgical resection is deemed unattainable.

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

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Liver Transplantation for Liver Metastasis of a Pseudopapillary Pancreatic Neoplasm in a Male Patient

et al. 2023

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“…Radiation therapy has been successfully used for recurrent tumors with good long-term prognosis. (28,29)…”

Section: Resultsmentioning

confidence: 99%

Pediatric solid pseudopapillary neoplasm of the pancreas

Samuel,

Boddu,

Sebastian

et al. 2023

Preprint

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Background: Solid pseudopapillary neoplasm of the pancreas (SPN) in children is rare tumor with low malignant potential. Some tumors however behave aggressively. There is very little literature on the management of these variants especially in children. We share our experience of managing large and recurrent SPN and explore the clinicopathological findings correlating to the risk of recurrence. Methods: This is a retrospective study of children who were treated for SPN between 2012 and 2022 at a tertiary care center in India. The clinicopathological features and management strategies in these children were evaluated. Results: 16 children with SPN were treated during this period (88% girls). The median age of presentation was 12 years (IQR 9-14). All children presented with abdominal pain. Computed tomography gave a definitive diagnosis in 81% of cases. The tumor predominantly involved the head of the pancreas (n=9, 56%). Eight of nine children classified as high-grade malignant had a benign course. One child had a recurrence of the tumor 4 years after the initial resection and further recurrence on chemotherapy. She required radiation therapy in addition to reoperation following which she is disease free for 77 months. The overall median follow-up was 46 months (IQR 18-72 months). Conclusion: Complete resection of the tumor provides a cure in most patients with SPN. Recurrent tumors require a multi-modality approach. Long-term survival is good. Better prognostic criteria with immunohistochemistry are required to predict the behavior of these tumors as the WHO criteria for malignancy correlate poorly with clinical outcomes in childhood SPN.

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“…The prognosis is favorable even in the presence of distant metastases. Recurrence rates are low, and 5 year survival as high as 97% [ 6 , 17 ].…”

Section: Discussionmentioning

confidence: 99%

The diagnosis and management of solid pseudopapillary epithelial neoplasm of the pancreas in a resource-limited setting: two cases from Cameroon

Shu,

Ngock,

Lisongwe

et al. 2024

Journal of Surgical Case Reports

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Solid pseudopapillary epithelial neoplasm (SPEN) of the pancreas is a rare tumor of low malignant potential that occurs most often in young females. Imaging and histopathology are necessary to confirm the diagnosis as most have no symptoms. Lack of access to these technologies in sub-Saharan Africa contributes to the difficulty in making an early and accurate diagnosis, and hence, impedes treatment. We present two cases of SPEN of the pancreas in young female patients at a rural, teaching hospital in Cameroon. The diagnosis was made only with histopathology. Computed tomography scan with intravenous contrast was essential to planning a safe surgical resection. Both patients had complete surgical resection with good results.

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Multidisciplinary treatment of advanced or recurrent solid pseudopapillary neoplasm of the pancreas: three case reports

Cited by 22 publications

References 30 publications

Liver Transplantation for Liver Metastasis of a Pseudopapillary Pancreatic Neoplasm in a Male Patient

Liver Transplantation for Liver Metastasis of a Pseudopapillary Pancreatic Neoplasm in a Male Patient

Pediatric solid pseudopapillary neoplasm of the pancreas

The diagnosis and management of solid pseudopapillary epithelial neoplasm of the pancreas in a resource-limited setting: two cases from Cameroon

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