Multidisciplinary Weight Loss Programs Lead to Statistically Significant Reductions in Liver Enzyme Levels in Obese Patients with Non-Alcoholic Fatty Liver Disease

Schwasinger-Schmidt, Tiffany; Paull-Forney, Bobbie; Bimali, Milan; Tofteland, Nathan; Salyers, William; Elhomsy, Georges

doi:10.1016/s0016-5085(17)32410-1

Cited by 1 publication

(6 citation statements)

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“…In the retrospective cohort by Schwasinger‐Schmidt et al., there was an average weight loss of 13% of body weight, 44% reduction in ALT, and 41% reduction in AST over 12 weeks. 23 In the Doyle et al. retrospective cohort study, BMI was reduced from 32.7 to 28.3 kg/m 2 , whereas liver steatosis decreased from 29.3% to 4.75% per liver biopsies before and after VLCD.…”

Section: Resultsmentioning

confidence: 95%

“…Subjects were required to have a clinical diagnosis of NAFLD and the average BMI was 45. 23 The retrospective cohort study by Doyle et al. 24 included all potential liver donors with hepatic steatosis ≥10% at baseline, who were placed on a VLCD, and had liver biopsies at follow up.…”

Section: Resultsmentioning

confidence: 99%

“…Outcomes included reductions in liver enzymes, weight changes, and waist circumference. 23 In the retrospective cohort study by Doyle et al, participants were on a 900 kcal/day diet for a median of 7.3 weeks. Changes in BMI, post‐intervention liver biopsies, and donor/recipient outcomes were recorded.…”

Section: Resultsmentioning

confidence: 99%

“…In the retrospective cohort study by Schwasinger‐Schmidt et al., they included individuals taking part in a physician‐directed, community‐based weight management program. Subjects were required to have a clinical diagnosis of NAFLD and the average BMI was 45 23 . The retrospective cohort study by Doyle et al 24 .…”

Section: Resultsmentioning

confidence: 99%

“…22 In the retrospective cohort by Schwasinger-Schmidt et al, there was an average weight loss of 13% of body weight, 44% reduction in ALT, and 41% reduction in AST over 12 weeks. 23 In the Doyle et al…”

Section: Weight Loss and Liver Disease Outcomesmentioning

confidence: 99%

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The use of very low‐calorie diets in subjects with obesity complicated with nonalcoholic fatty liver disease: A scoping review

Herrington

Peterson

Cheng

et al. 2022

Obesity Science & Practice

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This scoping review synthesizes the existing research on the use of very low‐calorie diets (VLCDs) in subjects with nonalcoholic fatty liver disease (NAFLD) and end‐stage liver disease (ESLD). 19 studies were included, of which 5 were clinical trials, 11 were cohort studies, 1 was a case‐control study, and 2 were case series totaling 968 subjects. About 17 studies were focused on patients with NAFLD while the two case series described in patients with ESLD on the transplant list or post‐liver transplant. Six studies included subjects managed with VLCDs prior bariatric surgery. Most studies were short term and demonstrated acute improvement of diverse liver biomarkers including liver function tests, indices of hepatosteatosis and reduction in liver size. Adherence rates in these studies were between 69% and 93%. Eight studies did not report any adverse events and four subjects were reported to have discontinued VLCD due to adverse effects in two different studies. Aggregated adverse events were mild. Treatments based on VLCD in subjects with NAFLD seem to be safe and tolerable but can result in mild adverse effects. The findings of this scoping review suggest that the use of VLCD in patients with obesity complicated with NAFLD and potentially in ESLD appear to be effective to induce weight loss and to acutely reduce hepatosteatosis.

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Section: Resultsmentioning

confidence: 95%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Weight Loss and Liver Disease Outcomesmentioning

confidence: 99%

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