In recent years, paradigms like production quality or zero-defect manufacturing have emerged, highlighting the need to improve quality and reduce waste in manufacturing systems. Although quality can be analyzed from various points of view during different stages of a manufacturing system’s lifecycle, this research focuses on a multidomain simulation model definition oriented toward the analysis of productivity and geometric quality during early design stages. To avoid inconsistencies, the authors explored the definition of descriptive models using system modeling language (SysML) profiles that capture domain-specific semantics defining object constraint language (OCL) rules, facilitating the assurance of model completeness and consistency regarding this specific knowledge. This paper presents a SysML profile for the simulation of geometric deviation propagation in multistage manufacturing systems (SysML4GDPSim), containing the concepts for the analysis of two data flows: (a) coupled discrete behavior simulation characteristic of manufacturing systems defined using discrete events simulation (DEVS) formalism; and (b) geometric deviation propagation through the system based on the geometrical modeling of artifacts using concepts from the topologically and technologically related surfaces (TTRS) theory. Consistency checking for this type of multidomain simulation model and the adoption of TTRS for the mathematical analysis of geometric deviations are the main contributions of this work, oriented towards facilitating the collaboration between design and analysis experts in the manufacturing domain. Finally, a case study shows the application of the proposed profile for the simulation model of an assembling line, including the model’s transformation to Modelica and some experimental results of this type of analysis.