Multidrug Resistance‐Associated Protein (MRP/ABCC Proteins)

Honorat, Mylène; Dumontet, Charles; Payen, Léa

doi:10.1002/9780470495131.ch2

Cited by 1 publication

(3 citation statements)

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“…So far, this subfamily includes a total of 13 members, most of which are active ATP-dependent membrane transporters for organic anions of therapeutic compounds (Honorat et al, 2009). Among its members, at least five (ABCC1, ABCC2, ABCC3, ABCC4 and ABC5) are potentially involved in mediating drug resistance (Cole et al, 1992; Kool et al, 1997; Evers et al, 1998).…”

Section: The Superfamily Of Abc Efflux Transportersmentioning

confidence: 99%

“…After the discovery of ABCB1, the study on cancer cells displaying MDR phenotype not associated with ABCB1 expression, led to the discovery of ABCC1, the founding member of the ABCC subfamily (Cole et al, 1992 ). So far, this subfamily includes a total of 13 members, most of which are active ATP-dependent membrane transporters for organic anions of therapeutic compounds (Honorat et al, 2009 ). Among its members, at least five (ABCC1, ABCC2, ABCC3, ABCC4 and ABC5) are potentially involved in mediating drug resistance (Cole et al, 1992 ; Kool et al, 1997 ; Evers et al, 1998 ).…”

Section: The Superfamily Of Abc Efflux Transportersmentioning

confidence: 99%

“…Among its members, at least five (ABCC1, ABCC2, ABCC3, ABCC4 and ABC5) are potentially involved in mediating drug resistance (Cole et al, 1992 ; Kool et al, 1997 ; Evers et al, 1998 ). Members of the ABCC subfamily can fall in one of two different subclasses, “short” and “long” (Kast and Gros, 1997 ; Bakos and Homolya, 2007 ; Honorat et al, 2009 ). The so called “long” ABCC transporters (ABCC1, 2, 3, and 6) present an additional N- terminal MSD (MSD0), of approximately 250 amino acids, a unique feature of these specific transporters (Figure 2B ) in comparison to the “short” transporters.…”

Section: The Superfamily Of Abc Efflux Transportersmentioning

confidence: 99%

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ABC transporters in fish species: a review

2014

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ATP-binding cassette (ABC) proteins were first recognized for their role in multidrug resistance (MDR) in chemotherapeutic treatments, which is a major impediment for the successful treatment of many forms of malignant tumors in humans. These proteins, highly conserved throughout vertebrate species, were later related to cellular detoxification and accounted as responsible for protecting aquatic organisms from xenobiotic insults in the so-called multixenobiotic resistance mechanism (MXR). In recent years, research on these proteins in aquatic species has highlighted their importance in the detoxification mechanisms in fish thus it is necessary to continue these studies. Several transporters have been pointed out as relevant in the ecotoxicological context associated to the transport of xenobiotics, such as P-glycoproteins (Pgps), multidrug-resistance-associated proteins (MRPs 1-5) and breast cancer resistance associated protein (BCRP). In mammals, several nuclear receptors have been identified as mediators of phase I and II metabolizing enzymes and ABC transporters. In aquatic species, knowledge on co-regulation of the detoxification mechanism is scarce and needs to be addressed. The interaction of emergent contaminants that can act as chemosensitizers, with ABC transporters in aquatic organisms can compromise detoxification processes and have population effects and should be studied in more detail. This review intends to summarize the recent advances in research on MXR mechanisms in fish species, focusing in (1) regulation and functioning of ABC proteins; (2) cooperation with phase I and II biotransformation enzymes; and (3) ecotoxicological relevance and information on emergent pollutants with ability to modulate ABC transporters expression and activity. Several lines of evidence are clearly suggesting the important role of these transporters in detoxification mechanisms and must be further investigated in fish to underlay the mechanism to consider their use as biomarkers in environmental monitoring.

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Section: The Superfamily Of Abc Efflux Transportersmentioning

confidence: 99%