Multidrug-resistant<i>Acinetobacter baumannii</i>infections: looming threat in the Indian clinical setting

Chandra, Prashant; Rajesh, V; Surulivelrajan, M; Cs, Shastry; Mk, Unnikrishnan

doi:10.1080/14787210.2022.2016393

Cited by 11 publications

(4 citation statements)

References 66 publications

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“…Although current evidence suggests involving patients and families in their care to reduce these infections [24,25], our research found that only a small proportion of patients (1.5%) had such an opportunity. Prior studies on patient and family engagement initiatives included teaching and training them about urinary catheter use, the risks associated with indwelling urinary catheters, how to recognize the signs of CAUTIs, periurethral skin care (e.g., cleaning the insertion site, hand hygiene, bathing recommendations), and urinary catheter maintenance (e.g., keeping a closed system, proper bag placement, bag changing/emptying procedures) [26,27].…”

Section: Discussioncontrasting

confidence: 67%

Nurses’ Adherence to the Portuguese Standard to Prevent Catheter-Associated Urinary Tract Infections (CAUTIs): An Observational Study

Paiva-Santos,

Santos-Costa,

Bastos

et al. 2023

Nursing Reports

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Urinary tract infections are among the most prevalent types of healthcare-associated infections (HAIs) in hospitals and nursing homes, and they are primarily a result of unnecessary catheter usage and inadequate care. In Portugal, epidemiological data indicate that catheter-associated urinary tract infections (CAUTIs) remain widespread in clinical settings, resulting in increased morbidity and mortality rates among vulnerable populations. This study aimed to assess urinary catheter use in an oncology ward in Portugal and to evaluate nurses’ adherence to the government-endorsed standards for preventing CAUTIs. An observational study was conducted over a four-month period with daily assessments of nurses’ practices during urinary catheter insertion and maintenance using a government-endorsed auditing tool. Data were collected through on-site observations and nurses’ feedback. The findings revealed a urinary catheter utilization rate of 17.99%. However, there was a lack of complete adherence to government-endorsed standards among oncology nurses (0%). These results indicate that current practices lack evidence-based standardization. Therefore, there is a need to develop and implement quality improvement initiatives to enhance patient safety and experiences.

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Section: Discussioncontrasting

confidence: 67%

Nurses’ Adherence to the Portuguese Standard to Prevent Catheter-Associated Urinary Tract Infections (CAUTIs): An Observational Study

Paiva-Santos,

Santos-Costa,

Bastos

et al. 2023

Nursing Reports

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“…In a recent systematic review on the susceptibility of A. baumannii to colistin in Iran, a resistance rate of 4% had been estimated ( 30 ). Finally, in several studies, A. baumannii resistance to colistin is a big threat to medical centers in the next few years ( 31 – 34 ). The results of a study in Iran show that most clinical isolates of A. baumannii in our hospital are MDR.…”

Section: Discussionmentioning

confidence: 99%

Determine phenotypical patterns of resistance to antibiotics in COVID-19 patients with associated bacterial infection: largest medical center in Iran

Mohammadnejad

Seifi

Gheshlagh

et al. 2023

IJM

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Background and Objectives: Antibacterial resistance (AMR) is a serious threat and major concern, especially in developing countries. Therefore, we aimed to determine phenotypical patterns of resistance to antibiotics in COVID-19 patients with associated bacterial infection in intensive care units. Materials and Methods: In this cross-sectional study, 6524 COVID-19 patients admitted for more than 48 h in the ICUs of Imam Khomeini Complex Hospital (IKCH) in Tehran from March 2020 to January 2022 were included in the study with initial diagnosis of COVID-19 (PCR test and chest imaging). Data were collected regarding severity of the illness, primary reason for ICU admission, presence of risk factors, presence of infection, length of ICU and hospital stay, microbial type, and antibiotic resistance. In this study, the pattern of antibiotic resistance was determined using the Kirby–Bauer disk diffusion method. Results: In this study, 439 (37.5%) were ventilator-related events (VAEs), and 46% of all hospitalized patients had an under- lying disease. The most common microorganisms in COVID-19 patients were carbapenem resistant Klebsiella pneumoniae (KPCs) (31.6%), Escherichia coli (E. coli) (15.8%), and Acinetobacter baumannii (A. baumannii) (15.7%), respectively. Prevalence of vancomycin-resistant enterococci (VRE) and KPCs were 88% and 82%, respectively. Conclusion: A study on AMR surveillance is the need of the hour as it will help centers to generate local antibiograms that will further help formulate national data. It will guide doctors to choose the appropriate empiric treatment, and these studies will be the basis for establishing antimicrobial surveillance and monitoring and regulating of the use of antimicrobials.

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“…Kerala (2018) was one of the first Indian states to establish policies and prioritize activities to address AMR hazards, followed by Madhya Pradesh and New Delhi (2020). However, ensuring the state-wide execution of an AMR action plan needs collaborative and committed efforts from healthcare professionals from both private and public sectors (Chandra et al, 2022;Singh et al, 2021). Neonatologists must be familiar with the bacteriological profile and the local geographic susceptibility patterns to reduce the morbidity and mortality associated with NS.…”

Section: Discussionmentioning

confidence: 99%

Neonatal outcomes associated with antimicrobial resistance: A retrospective cross-sectional study

Chandra¹,

Iqbal²,

Unnikrisnan³

et al. 2023

J App Pharm Sc

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Neonatal sepsis (NS) is a leading cause of morbidity and mortality requiring immediate admission and prolonged neonatal intensive care unit (NICU) stay. This study attempts to identify factors associated with NS and its outcomes. A total of 186 NS cases records (January 2017 to September 2019) were analyzed retrospectively. Multiple logistic regression and linear regression were employed to determine the factors associated with mortality, length of NICU stay, and treatment cost with a significance level of p ≤ 0.05. The mean neonatal age was 6.8 ± 9.5 days. Culture reports identified Klebsiella pneumonia (69%) as the major pathogen. Forty-four percent of neonates died, of whom 57% and 44% suffered early-onset sepsis and late-onset sepsis respectively. Logistic regression showed that mortality was significantly associated with platelet count (OR = 0.998; 95% CI =0.996-1.000) and very low birth weight (LBW) (OR = 2.427; 95% CI = 1.103-5.342). Linear regression showed that the number of definitive antibiotics used was associated with prolonged length of NICU stay. Also, length of NICU stay, number of definitive antibiotics, seizures, and heart disease, were significantly associated with overall cost. Mortality was higher with early-onset of sepsis than with late-onset of sepsis. The study could help policymakers and clinical practitioners to develop and implement targeted interventions that potentially reduce the global prevalence of NS.

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Multidrug-resistantAcinetobacter baumanniiinfections: looming threat in the Indian clinical setting

Cited by 11 publications

References 66 publications

Nurses’ Adherence to the Portuguese Standard to Prevent Catheter-Associated Urinary Tract Infections (CAUTIs): An Observational Study

Nurses’ Adherence to the Portuguese Standard to Prevent Catheter-Associated Urinary Tract Infections (CAUTIs): An Observational Study

Determine phenotypical patterns of resistance to antibiotics in COVID-19 patients with associated bacterial infection: largest medical center in Iran

Neonatal outcomes associated with antimicrobial resistance: A retrospective cross-sectional study

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