Multidrug Resistant Tuberculosis; a Pharmacological view based on Revised National Tuberculosis Control Programme DOTS-Plus Guidelines.

Singh, Harminder; Kaur, Kamalpreet; Girish, Pendharkar

doi:10.9790/3013-24206268

Cited by 3 publications

(3 citation statements)

References 24 publications

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“…Unfortunately, counterfeit TB drugs are also available on the global market alongside the generic drugs [ 46 ]. Counterfeit drugs are often not pharmacologically adequate, and their circulation may greatly contribute to the spread and development of drug resistance [ 47 ]. Adherent patients may believe they are taking the appropriate regimen when in fact the drug dosage is too low or is uneven, which is effectively equivalent to skipping pills [ 48 ].…”

Section: Discussionmentioning

confidence: 99%

Lessons from Africa: developing a global human rights framework for tuberculosis control and prevention

Slagle

Youssef

Calonge

et al. 2014

BMC Int Health Hum Rights

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BackgroundTuberculosis is a highly contagious disease, and there has been a rise in recent years of drug-resistant cases no longer responding to standard treatment.In order to address this threat and contain possible transmission of drug-resistant cases, some countries have taken strong action, including the compulsory detention of non-adherent drug-resistant patients. These measures have been strongly criticized by human rights advocates, and they raise the question of how to legally protect both citizens and the community.DiscussionFollowing discussions with National Tuberculosis Programs in Africa (the continent with the highest incidence rates of tuberculosis worldwide), we show that of all the countries surveyed, all but one (Swaziland) had either no specific policy addressing tuberculosis, or only general policies regarding public health applicable to tuberculosis. Six countries also reported having policies that address non-adherence to treatment with containment (isolation in health facilities or incarceration), but laws are not adequately enforced. If the international community wants to effectively respond to the threat of tuberculosis transmission, there is a need to go beyond national tuberculosis policies and to implement an international framework for tuberculosis control, inspired by the Framework Convention on Tobacco Control, a key model for future public health treaties that address global burdens of disease. The framework, for which we clarify the conditions and procedures in this piece, would define the rights and responsibilities of the different stakeholders involved: patients, doctors, pharmaceutical firms and public authorities. To facilitate the governance of the national obligations under the Convention, a coordinating body should be set up, under the leadership of the World Health Organization and the Stop TB Partnership.SummarySuccessfully implementing policies for tuberculosis that simultaneously address patients’ rights and communities’ wellbeing will have positive implications for those affected by the disease and serve as a basis for other global health conventions to truly ensure the global right to health.

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Section: Discussionmentioning

confidence: 99%

Lessons from Africa: developing a global human rights framework for tuberculosis control and prevention

Slagle

Youssef

Calonge

et al. 2014

BMC Int Health Hum Rights

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“…The most common is respiratory system (lungs) and the disease is called as pulmonary tuberculosis. When these bacilli are resistance to at least both Isoniazid (H) and Rifampicin (R) then these bacilli are called as multidrug-resistant and the disease known as multidrug-resistance tuberculosis (MDR-TB) [1]. If not treated properly, TB disease can be fatal.…”

Section: Introductionmentioning

confidence: 99%

To Evaluate the Magnitude of Depression in Multidrug-Resistant Tuberculosis Patients in a Tertiary Care Teaching Hospital

SINGH¹,

Kushwaha

Agrawal³

et al. 2023

Asian J Pharm Clin Res

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Objective: The objective of the study was to evaluate the magnitude of depression in multidrug-resistant tuberculosis patients in a tertiary care teaching hospital. Methods: An observational study was carried out in department of Psychiatry and department of Tuberculosis and Respiratory disease G.S.V.M. Medical College, Kanpur for a period of 9 months. The diagnosed multidrug-resistance tuberculosis (MDR-TB) patients coming to in-patient and out-patient department of tuberculosis and respiratory disease taking RNTCP regimen (Category IV) for MDR-TB will be screened for depression applying Hamilton Depression Rating Scale (HDRs) score and those patients who showed depression in screening will further send to psychiatry department for the final diagnosis of depression. We also categorized the patients into mild, moderate, and severe depression according to HDRs score. Data were tabulated in Microsoft Excel sheet. All categorical variables were analyzed using percentage. Results: We screened 148 MDR TB patients who were taking drug for MDRTB. The average duration of treatment were 5.19 Month. Out of 148 patients, 56 (37.84%) patients were found to be suffering from depression. Out of 56 Depressed MDR TB Patients, 35 (62.5%) were male and 21 (37.5%) were female patients and 26 (46.43%) were mild (HDRS Score-8–13), 28 (50%) were moderate (HDRS Score-14–18) and 2 (3.57%) were severely depressed (HDRS Score-19–20). Conclusion: The magnitude of depression in MDR TB Patients taking RNTCP regimen (Category IV) for MDR TB was 37.84% and out of these patients, 46.43% were mild, 50% were moderate, and 3.57% were severely depressed.

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“…Patients with MDR-TB are required to take several second-line anti-TB drugs for about two years. The long duration of exposure to treatment and diverse drugs prescribed increases the risk of adverse drug reactions (ADRs) that could negatively affect treatment adherence and consequently treatment success rate [2, 3]. …”

Section: Introductionmentioning

confidence: 99%

Risk Factors of Gout in MDR-TB Patients in Eritrea: A Case-Control Study

Russom

Tesfaselassie

Goitom

et al. 2019

Tuberculosis Research and Treatment

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Though the incidence of gout in general population is less than 5% (globally), a study conducted in Eritrea among patients with multidrug resistant tuberculosis (MDR-TB) revealed a higher incidence (25%). Other similar studies conducted elsewhere, however, did not report gout as an adverse effect. It is unknown why a higher incidence of gout is being reported in Eritrea compared to similar studies from other countries. The objective of this study is therefore to explore risk factors for the increased risk of incident gout among MDR-TB patients in Eritrea. A case-control study was conducted in Merhano MDR-TB National Referral Hospital in Eritrea. All MDR-TB patients diagnosed with gout between June 2011 and June 2018 were considered as cases. Controls matched by age, sex, and cumulative drug exposure time were selected from the same study population (1:1 ratio). A total of 84 MDR-TB patients, 42 cases and 42 controls, were included in this study. No patient from the control group has comorbidities, while six patients from the case group have diabetes (χ2 = 6.46, df=1, p=0.026). Patients having tachycardia (OR=3.26, 95% CI=1.28, 8.27), alopecia (OR=3.11, 95% CI=1.00, 9.67), and gastrointestinal upset (OR=3.17, 95% CI=1.26, 7.96) as adverse effects and being on prolonged use of propranolol (OR=3.26, 95% CI=1.28, 8.27) were found to be more likely to develop incident gout compared to their controls. In conclusion, MDR-TB patients with diabetes mellitus, tachycardia, alopecia, and gastrointestinal upset and on prolonged use of propranolol tablet had increased risk of incident gout.

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Multidrug Resistant Tuberculosis; a Pharmacological view based on Revised National Tuberculosis Control Programme DOTS-Plus Guidelines.

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Cited by 3 publications

References 24 publications

Lessons from Africa: developing a global human rights framework for tuberculosis control and prevention

Lessons from Africa: developing a global human rights framework for tuberculosis control and prevention

To Evaluate the Magnitude of Depression in Multidrug-Resistant Tuberculosis Patients in a Tertiary Care Teaching Hospital

Risk Factors of Gout in MDR-TB Patients in Eritrea: A Case-Control Study

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