Multidrug-resistant tuberculosis in Ethiopia: efforts to expand diagnostic services, treatment and care

Biadglegne, Fantahun; Sack, Ulrich; Rodloff, Arne C.

doi:10.1186/2047-2994-3-31

Cited by 48 publications

(52 citation statements)

References 36 publications

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“…It is due to human error as the result of poor supply management and quality of anti-TB drugs and inadequate or improper treatment, which is further exacerbated by human immunodeficiency virus (HIV) [12].Based on WHO recommendation, RMPMR was considered as surrogate marker for MDR TB. Therefore, we have determined the prevalence of Refampcin mono resistant Mycobacterium tuberculosis among suspected study subject and the finding associated with age and sex.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Refampcin Mono Resistant Mycobacterium Tuberculosis Among Suspected Cases Attending at Yirgalem Hospital

Hordofa¹,

Adela²

2015

CMR

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Section: Discussionmentioning

confidence: 99%

Prevalence of Refampcin Mono Resistant Mycobacterium Tuberculosis Among Suspected Cases Attending at Yirgalem Hospital

Hordofa¹,

Adela²

2015

CMR

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“…cases per 100,000 in 2013 9 . These days, drug resistant TB has become a common problem and challenge in Ethiopia 7 .…”

Section: Introductionmentioning

confidence: 98%

Risk factors for multidrug resistant tuberculosis patients in Amhara National Regional State.

Mulu¹,

Mekonnen²,

Yimer³

et al. 2015

Afr H. Sci.

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Background: Multidrug resistant tuberculosis(MDR-TB) is becoming a major threat to tuberculosis control programs in Ethiopia. Objectives: To determine risk factors of MDR-TB patients in Amhara National Regional State, Ethiopia. Methods: Case-control study was conducted from May 2013 to January 2014. Resistance to rifampicin and isoniazid were done molecularly using line probe assay. TB patients infected with MDR-M.tuberculosis and non MDR-M.tuberculosis strain were considered as cases and controls, respectively. Data was collected using structured questionnaire with face to face interview. Patients' clinical record review was also done.Multivariate analysis was computed to determine the risk factors of MDR-TB. Results: A total of 153 MDR-TB and equal number of non MDR-TB patients' participated in the study. Patients who had TB treatment failure (AOR=13.5,CI=2.69-70), cavitations on chest x-ray (AOR=1.9,CI=1.1-3.38) and contact with MDR-TB patients (AOR=1.4,CI=0.19-0.39) were more likely to be MDR-TB patients. Low monthly income (AOR=1.1,CI=0.34-0.47),alcohol consumption (AOR=1.5,CI=0.2-0.98) and young age (AOR=2.9,CI=1.07-7.68) were the other risk factors of MDR-TB. Conclusions: TB treatment failure, cavitation on chest X-ray, contact with MDR-TB patients and low socioeconomic status were important risk factors for development of MDR-TB. Therefore, strict adherence to directly observed therapy, appropriate management of TB patients and advice on the value of nutrients are helpful to control the spreading of MDR-TB.

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“…The annual TB incidence and prevalence of Ethiopia is estimated to be 247 and 470 cases per 100,000 (Biadglegne et al, 2014). These days, drug resistant TB has become a common problem and challenge in Ethiopia.…”

Section: Introductionmentioning

confidence: 99%

“…It causes illness among millions of people each year and is ranked as the second leading cause of death from an infectious disease worldwide (Biadglegne et al, 2014). Multidrug-resistant tuberculosis (MDR-TB) is a form of drug-resistant TB in which Mycobacterium tuberculosis can no longer be killed by the two best antibiotics most commonly used to cure TB, Isoniazid and Rifampicin.…”

Section: Introductionmentioning

confidence: 99%

Actual practice of healthcare providers towards prevention and control of Multidrug-resistant tuberculosis (MDR-TB) at Borumeda Hospital, Ethiopia

Aklilu¹,

Seid²

2017

Afr. J. Pharm. Pharmacol.

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Tuberculosis (TB) is the world's leading curable cause of infectious diseases mortality, with a disproportionate burden of the disease falling on low and middle income countries. In 2013, there was an estimated 9 million incident cases of TB globally and 1.5 million people died from the disease. The estimated number of cases occurred in Asia (56%) and Africa (25%), the incidence rates are highest, driven by high rates of HIV and malnutrition. Ethiopia is one of the high burden countries, reflected both in its TB incidence and the estimated rates of Multidrug-resistant tuberculosis (MDR-TB). With the occurrence of MDR-TB, little is known about the views of healthcare workers on this disease. The oblective of this study was to assess the knowledge, attitudes and practices of healthcare professionals towards prevention and control of MDR-TB at Boru Meda General Hospital, South Wollo Zone, North central Ethiopia. A cross sectional study was conducted by means of a semi-structured, self-administered questionnaire that was sent to all healthcare workers. The questionnaires were collected at the study site from March 22 to April 23, 2014. In all, greater than half (80.85%) of the respondents had good level of knowledge about MDR-TB; and the overwhelming majority of them held positive attitude (76.60%) towards patients with MDR-TB. In totality, 31.91, 74.11 and 66.35% of the respondents reported that they had their own copy of MDR-TB management guidelines; they used the protective masks and they were individually involved in educating patients about MDR-TB, respectively. Greater than half of the respondents had good level of knowledge about MDR-TB, but some of them held negative attitude towards patients suffering from MDR-TB. The attitude did not influence practices, but having good level of knowledge was positively associated with safer practices such as using protective masks, educating patients on MDR-TB, and referring to the MDR-TB guidelines manual.

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Multidrug-resistant tuberculosis in Ethiopia: efforts to expand diagnostic services, treatment and care

Cited by 48 publications

References 36 publications

Prevalence of Refampcin Mono Resistant Mycobacterium Tuberculosis Among Suspected Cases Attending at Yirgalem Hospital

Prevalence of Refampcin Mono Resistant Mycobacterium Tuberculosis Among Suspected Cases Attending at Yirgalem Hospital

Risk factors for multidrug resistant tuberculosis patients in Amhara National Regional State.

Actual practice of healthcare providers towards prevention and control of Multidrug-resistant tuberculosis (MDR-TB) at Borumeda Hospital, Ethiopia

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