Cross sections of laboratory CNO and rp astrophysical reactions are enhanced due to the presence of the multi-electron cloud that surrounds the target nuclei. As a result the relevant astrophysical factors are overestimated unless corrected appropriately. This study gives both an estimate of the error committed if screening effects are not taken into account and a rough profile of the laboratory energy thresholds at which the screening effect appears. The results indicate that, for most practical purposes, screening corrections to past relevant experiments can be disregarded. Regarding future experiments, however, screening corrections to the CNO reactions will certainly be of importance as they are closely related to the solar neutrino fluxes and the rp process. Moreover, according to the present results, screening effects will have to be taken into account particularly by the current and future LUNA experiments, where screened astrophysical factors will be enhanced to a significant degree. PACS number(s): 26.30.+k, 25.60.Dz, 25.60.Pj, 25.70.Gh., 26.65.+t Typeset using REVT E X * www.liolios.info