Multifaceted roles of cyclooxygenase-2 in lung cancer

Riedl, Karen; Krysan, Kostyantyn; Põld, Mehis; Dalwadi, Harnisha; Heuzé-Vourc’h, Nathalie; Dohadwala, Mariam; Liu, Ming; Cui, Xiaoyan; Figlin, Robert A.; Mao, Jenny T.; Strieter, Robert M.; Sharma, Sherven; Dubinett, Steven M.

doi:10.1016/j.drup.2004.04.003

Cited by 86 publications

(77 citation statements)

References 152 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Elevated Cox-2 expression has been found in a variety of human cancers including NSCLC (Chun and Surh, 2004;Riedl et al, 2004). Our results are consistent with the possibility that Foxm1-dependent Cox-2 induction contributes to sustained inflammatory response and elevated tumorigenesis in MCA/BHT-treated Rosa26-Foxm1 lungs.…”

Section: Foxm1 Induces Formation Of Lung Tumors I-c Wang Et Alsupporting

confidence: 90%

“…In this study, we demonstrated for the first time that Foxm1 plays a role in chronic lung inflammation, a known predisposing factor for tumor development. Although pulmonary inflammation was completely resolved by 12 weeks after initiation of MCA/BHT treatment in WT mice, Rosa26-Foxm1 mice displayed persistent pulmonary inflammation, macrophage infiltration, and increased expression of genes essential for pulmonary inflammation and remodeling in response to lung injury (Bratt, 2000;Wolters and Chapman, 2000;Chun and Surh, 2004;Kulbe et al, 2004;Riedl et al, 2004;Acuff et al, 2006). Therefore, the observed changes in gene expression probably represent the increased inflammatory response in MCA/BHT-treated Rosa26-Foxm1 lungs compared to WT lungs.…”

Section: Foxm1 Induces Formation Of Lung Tumors I-c Wang Et Almentioning

confidence: 99%

“…Interestingly, by 24 weeks after tumor initiation, expression levels of these genes were decreased in the Rosa26-Foxm1 lungs to approximately WT levels ( Figure 3). Furthermore, lungs from MCA/BHT-treated Rosa26-Foxm1 mice displayed a significant increase in expression levels of Rosa26-Foxm1 transgenic lungs exhibit elevated Cox-2 levels Previous studies demonstrated that the expression of Cyclooxygenese-2 (Cox-2) is induced during pulmonary inflammation and lung carcinogenesis (Chun and Surh, 2004;Riedl et al, 2004). Since microarray analysis revealed increased Cox-2 levels in MCA/BHT-treated Rosa26-Foxm1 lungs (Table 2), we hypothesized that Foxm1 directly or indirectly regulates Cox-2 expression.…”

Section: Foxm1 Induces Formation Of Lung Tumors I-c Wang Et Almentioning

confidence: 99%

“…Sustained inflammation and increased tumorigenesis in Rosa26-Foxm1 lungs was associated with increased expression of Cox-2, a well-known marker of inflammation and a critical player in carcinogenesis Foxm1 induces formation of lung tumors I-C Wang et al (Chun and Surh, 2004;Riedl et al, 2004). Elevated Cox-2 expression has been found in a variety of human cancers including NSCLC (Chun and Surh, 2004;Riedl et al, 2004).…”

Section: Foxm1 Induces Formation Of Lung Tumors I-c Wang Et Almentioning

confidence: 99%

See 3 more Smart Citations

Transgenic expression of the forkhead box M1 transcription factor induces formation of lung tumors

et al. 2008

View full text Add to dashboard Cite

The forkhead box m1 (Foxm1 or Foxm1b) protein (previously called HFH-11B, Trident, Win or MPP2) is abundantly expressed in human non-small cell lung cancers where it transcriptionally induces expression of genes essential for proliferation of tumor cells. In this study, we used Rosa26-Foxm1 transgenic mice, in which the Rosa26 promoter drives ubiquitous expression of Foxm1 transgene, to identify new signaling pathways regulated by Foxm1. Lung tumors were induced in Rosa26-Foxm1 mice using the 3-methylcholanthrene (MCA)/butylated hydroxytoluene (BHT) lung tumor initiation/promotion protocol. Tumors from MCA/BHTtreated Rosa26-Foxm1 mice displayed a significant increase in the number, size and DNA replication compared to wild-type mice. Elevated tumor formation in Rosa26-Foxm1 transgenic lungs was associated with persistent pulmonary inflammation, macrophage infiltration and increased expression of cyclooxygenase-2 (Cox-2), Cdc25C phosphatase, cyclin E2, chemokine ligands CXCL5, CXCL1 and CCL3, cathepsins and matrix metalloprotease-12. Cell culture experiments with A549 human lung adenocarcinoma cells demonstrated that depletion of Foxm1 by either short interfering RNA transfection or treatment with Foxm1-inhibiting ARF 26-44 peptide significantly reduced Cox-2 expression. In co-transfection experiments, Foxm1 protein-induced Cox-2 promoter activity and directly bound to the À2566/ À2580 bp region of human Cox-2 promoter.

show abstract

Section: Foxm1 Induces Formation Of Lung Tumors I-c Wang Et Alsupporting

confidence: 90%

Section: Foxm1 Induces Formation Of Lung Tumors I-c Wang Et Almentioning

confidence: 99%

Section: Foxm1 Induces Formation Of Lung Tumors I-c Wang Et Almentioning

confidence: 99%

Section: Foxm1 Induces Formation Of Lung Tumors I-c Wang Et Almentioning

confidence: 99%

See 2 more Smart Citations

Transgenic expression of the forkhead box M1 transcription factor induces formation of lung tumors

et al. 2008

View full text Add to dashboard Cite

show abstract

“…COX-2 expression is induced by cytokines and growth factors at sites of inflammation and is usually not detected in normal tissues [94]. Increased COX-2 expression and PGE 2 production has been reported in human colon carcinoma [95], breast cancer [96,97], renal cell carcinoma [98], and lung carcinoma [99].…”

Section: Pgementioning

confidence: 99%

The Multifaceted Roles Neutrophils Play in the Tumor Microenvironment

Sionov

Fridlender

Granot

2014

Cancer Microenvironment

342

261

View full text Add to dashboard Cite

Neutrophils are myeloid cells that constitute 50-70 % of all white blood cells in the human circulation. Traditionally, neutrophils are viewed as the first line of defense against infections and as a major component of the inflammatory process. In addition, accumulating evidence suggest that neutrophils may also play a key role in multiple aspects of cancer biology. The possible involvement of neutrophils in cancer prevention and promotion was already suggested more than half a century ago, however, despite being the major component of the immune system, their contribution has often been overshadowed by other immune components such as lymphocytes and macrophages. Neutrophils seem to have conflicting functions in cancer and can be classified into anti-tumor (N1) and pro-tumor (N2) sub-populations. The aim of this review is to discuss the varying nature of neutrophil function in the cancer microenvironment with a specific emphasis on the mechanisms that regulate neutrophil mobilization, recruitment and activation.

show abstract

COX‐2 in lung cancer: Mechanisms, development, and targeted therapies

Liu,

Zhang,

Sun

et al. 2024

Chronic Diseases and Translational Medicine

View full text Add to dashboard Cite

Lung cancer (LC) is the leading cause of cancer‐related death worldwide, with non‐small cell lung cancer (NSCLC) comprising 85% of all cases. COX‐2, an enzyme induced significantly under stress conditions, catalyzes the conversion of free arachidonic acid into prostaglandins. It exhibits high expression in various tumors and is closely linked to LC progression. COX‐2 functions as a pivotal driver in cancer pathogenesis by promoting prostaglandin E2 synthesis and facilitating tumor cell occurrence and development. Furthermore, COX‐2 holds potential as a predictive marker for early‐stage NSCLC, guiding targeted therapy in patients with early COX‐2 overexpression. Additionally, combining COX‐2 inhibitors with diverse treatment modalities enhances tumor therapeutic efficacy, minimizes adverse effects on healthy tissues, and improves overall patient survival rates posttreatment. In conclusion, combined therapy targeting COX‐2 presents a promising novel strategy for NSCLC treatment, offering avenues for improving prognosis and effective tumor treatment. This review provides novel insights and ideas for developing new treatment strategies to improve the prognosis of NSCLC.

show abstract

Multifaceted roles of cyclooxygenase-2 in lung cancer

Cited by 86 publications

References 152 publications

Transgenic expression of the forkhead box M1 transcription factor induces formation of lung tumors

Transgenic expression of the forkhead box M1 transcription factor induces formation of lung tumors

The Multifaceted Roles Neutrophils Play in the Tumor Microenvironment

COX‐2 in lung cancer: Mechanisms, development, and targeted therapies

Contact Info

Product

Resources

About