Multifaceted Roles of MicroRNAs in Host-Bacterial Pathogen Interaction

Aguilar, Carmen; Mano, Miguel; Eulálio, Ana

doi:10.1128/9781683670261.ch17

Cited by 3 publications

(24 citation statements)

References 140 publications

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“…This study illustrated miR‐146 as an anti‐inflammatory miRNA contributing to the fine‐tuning of the host immune response through the regulation of toll‐like receptor 4 (TLR‐4) and cytokine signaling (Aguilar et al, 2019a). Consistent with a comprehensive role of miRNAs in gene expression regulation, miRNAs have been shown to regulate numerous fundamental biological processes (e.g., cellular proliferation, differentiation, apoptosis (Aguilar et al, 2019b) signal transduction (Kalla et al, 2015) metabolic pathways, immune response, development (Das et al, 2016), and autophagy (Silwal et al, 2020)). miRNA dysregulation has been involved in many human diseases (Aguilar et al, 2019b), infectious diseases, autoimmune diseases, chronic inflammatory diseases (Luan et al, 2018), cancer, kidney failure, cardiac disease, diabetes, and liver cirrhosis (Das et al, 2016; Kloosterman & Plasterk, 2006; Trionfini et al, 2015).…”

Section: Introductionmentioning

confidence: 87%

“…pylori infection to promote cell proliferation and, ultimately, favor tumorigenesis, H. pylori has also been shown to block cell proliferation and cell cycle progression in gastric epithelial cells through the regulation of miRNAs (Belair et al, 2011;Wang et al, 2017). Indeed, (Aguilar et al, 2019b). For example, miR-155 is strongly upregulated upon H. pylori infection, both in vitro (epithelial cells, lymphocytes, and macrophages and in vivo (human biopsies of infected gastric mucosa; Fehri et al, 2010;Koch et al, 2012;Lario et al, 2012;Oertli et al, 2011;Xiao et al, 2009).…”

Section: Helicobacter Pylorimentioning

confidence: 99%

“…Advancements in RNA sequencing have contributed to the extensive analysis of the host miRNome and contributed to demonstrating that infection by different bacterial pathogens induces main miRNome changes, as illustrated above for L. However, a standard set of miRNAs regulated as part of the host immune response (e.g., miR-155, miR-146, and let-7) has been characterized for a broad spectrum of pathogens (Aguilar et al, 2019b). Indeed, research over miRNA has provided a new and exciting approach to study the basic mechanisms of interaction between the host-microbial pathogens.…”

Section: Perspectivementioning

confidence: 99%

“…Molecular geneticists researching the lin‐4 and let‐7 genes, each required for the appropriate timing of C. elegans development, found that these genes produce noncoding RNAs (ncRNAs) rather than producing mRNAs (Bartel, 2018). miRNAs are classified as single‐stranded small noncoding RNA fragments (typically 20–22 nucleotides long; Aguilar et al, 2019a, 2019b). These molecules encoded in genomic DNA (Kalla et al, 2015) and play vital roles in posttranscriptional gene regulation in a wide range of organisms, containing animals, plants, and viruses (Aguilar et al, 2019a).…”

Section: Introductionmentioning

confidence: 99%

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MicroRNAs in the interaction between host–bacterial pathogens: A new perspective

Rad

Goudarzi

et al. 2021

Journal Cellular Physiology

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Gene expression regulation plays a critical role in host-pathogen interactions, and RNAs function is essential in this process. miRNAs are small noncoding, endogenous RNA fragments that affect stability and/or translation of mRNAs, act as major posttranscriptional regulators of gene expression. miRNA is involved in regulating many biological or pathological processes through targeting specific mRNAs, including development, differentiation, apoptosis, cell cycle, cytoskeleton organization, and autophagy. Deregulated microRNA expression is associated with many types of diseases, including cancers, immune disturbances, and infection. miRNAs are a vital section of the host immune response to bacterial-made infection. Bacterial pathogens suppress host miRNA expression for their benefit, promoting survival, replication, and persistence. The role played through miRNAs in interaction with host-bacterial pathogen has been extensively studied in the past 10 years, and knowledge about these staggering molecules' function can clarify the complicated and ambiguous interactions of the host-bacterial pathogen. Here, we review how pathogens prevent the host miRNA expression. We briefly discuss emerging themes in this field, including their role as biomarkers in identifying bacterial infections, as part of the gut microbiota, on host miRNA expression.

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Section: Introductionmentioning

confidence: 87%

Section: Helicobacter Pylorimentioning

confidence: 99%

Section: Perspectivementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

MicroRNAs in the interaction between host–bacterial pathogens: A new perspective

Rad

Goudarzi

et al. 2021

Journal Cellular Physiology

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“…miRNAs have also been recognized for their important role in the interactions between host and bacterial pathogens, either as an indispensable part of the host response to fight infection or as a molecular strategy utilized by bacterial pathogens to cause the dysregulation of host miRNA expression for their own benefit ( Aguilar et al, 2019a , b ). For example, miR-301b is involved in the augmentation of pro-inflammatory response during infection by Pseudomonas aeruginosa ( Li X. et al, 2016 ).…”

Section: Interactions Between Host Mirnas and Bacterial Pathogensmentioning

confidence: 99%

Probiotics and MicroRNA: Their Roles in the Host–Microbe Interactions

Zhao

Zeng

et al. 2021

Front. Microbiol.

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Probiotics are widely accepted to be beneficial for the maintenance of the gut homeostasis – the dynamic and healthy interactions between host and gut microorganisms. In addition, emerging as a key molecule of inter-domain communication, microRNAs (miRNAs) can also mediate the host–microbe interactions. However, a comprehensive description and summary of the association between miRNAs and probiotics have not been reported yet. In this review, we have discussed the roles of probiotics and miRNAs in host–microbe interactions and proposed the association of probiotics with altered miRNAs in various intestinal diseases and potential molecular mechanisms underlying the action of probiotics. Furthermore, we provided a perspective of probiotics–miRNA–host/gut microbiota axis applied in search of disease management highly associated with the gut microbiome, which will potentially prove to be beneficial for future studies.

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MicroRNAs: master regulators in host–parasitic protist interactions

et al. 2022

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MicroRNAs (miRNAs) are a group of small non-coding RNAs present in a wide diversity of organisms. MiRNAs regulate gene expression at a post-transcriptional level through their interaction with the 3′ untranslated regions of target mRNAs, inducing translational inhibition or mRNA destabilization and degradation. Thus, miRNAs regulate key biological processes, such as cell death, signal transduction, development, cellular proliferation and differentiation. The dysregulation of miRNAs biogenesis and function is related to the pathogenesis of diseases, including parasite infection. Moreover, during host–parasite interactions, parasites and host miRNAs determine the probability of infection and progression of the disease. The present review is focused on the possible role of miRNAs in the pathogenesis of diseases of clinical interest caused by parasitic protists. In addition, the potential role of miRNAs as targets for the design of drugs and diagnostic and prognostic markers of parasitic diseases is also discussed.

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Multifaceted Roles of MicroRNAs in Host-Bacterial Pathogen Interaction

Cited by 3 publications

References 140 publications

MicroRNAs in the interaction between host–bacterial pathogens: A new perspective

MicroRNAs in the interaction between host–bacterial pathogens: A new perspective

Probiotics and MicroRNA: Their Roles in the Host–Microbe Interactions

MicroRNAs: master regulators in host–parasitic protist interactions

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