Multifaceted roles of YEATS domain-containing proteins and novel links to neurological diseases

Yeewa, Ranchana; Chaiya, Pawita; Jantrapirom, Salinee; Shotelersuk, Vorasuk; Piccolo, Luca Lo

doi:10.1007/s00018-022-04218-0

Cited by 7 publications

(6 citation statements)

References 131 publications

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“…Strikingly, YEATS4 as a key hub gene was pinpointed in the module with high membership and gene significance for both body mass (cor = 0.89 and p < 2.2E‐16; Figure 4b) and altitude (cor = 0.98 and p < 2.2E‐16; Figure S10). YEATS4 has important functions in regulating RNA transcription and maintaining cellular proliferation (Yeewa et al, 2022). Several lines of evidence have suggested its role in modulating the p53–p21 pathway and controlling tumorigenesis related to the central nervous system (Park & Roeder, 2006).…”

Section: Resultsmentioning

confidence: 99%

“…In particular, we have identified a candidate gene, YEATS4 , whose accelerated evolution of potential regulatory regions probably shifted the expression in all four brain regions (cerebellum, left cerebrum, right cerebrum and brainstem). A great deal of experimental evidence has indicated that this gene can facilitate gene transcription, adjust cell division and body growth, and control tumour formation (Johnsson et al, 2018; Park & Roeder, 2006; Yeewa et al, 2022). As an important TF, YEATS4 regulates the expression of other downstream genes as well, thereby rapidly conferring adaptations to high‐altitude environmental stresses.…”

Section: Discussionmentioning

confidence: 99%

“…and altitude (cor = 0.98 and p < 2.2E-16; Figure S10). YEATS4 has important functions in regulating RNA transcription and maintaining cellular proliferation (Yeewa et al, 2022). Several lines of evidence have suggested its role in modulating the p53-p21 pathway and controlling tumorigenesis related to the central nervous system (Park & Roeder, 2006).…”

Section: Tfs Control Gene Expression Divergence By a Genetic Regulato...mentioning

confidence: 99%

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Divergent contributions of coding and noncoding sequences to initial high‐altitude adaptation in passerine birds endemic to the Qinghai–Tibet Plateau

et al. 2023

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Early events in the evolution of an ancestral lineage can shape the adaptive patterns of descendant species, but the evolutionary mechanisms driving initial adaptation from an ancestor remain largely unexplored. High‐altitude adaptations have been extensively explored from the viewpoint of protein‐coding genes; however, the contribution of noncoding regions remains relatively neglected. Here, we integrate genomic and transcriptomic data to investigate adaptive evolution in the ancestor of three high‐altitude snowfinch species endemic to the Qinghai–Tibet Plateau. Our genome‐wide scan for adaptation in the snowfinch ancestor identifies strong adaptation signals in functions of development and metabolism for the coding genes, but in functions of the nervous system development for noncoding regions. This pattern is exclusive to the snowfinch ancestor compared to a control ancestral lineage subject to weak selection. Changes in noncoding regions in the snowfinch ancestor, especially those nearest to coding genes, may be disproportionately associated with the differential expression of genes in the brain tissue compared to other tissues. Extensive gene expression in the brain tissue can be further altered via genetic regulatory networks of transcription factors harbouring potential accelerated regulatory regions (e.g., the development‐related transcription factor YEATS4). Altogether, our study provides new evidence concerning how coding and noncoding sequences work through decoupled pathways in initial adaptation to the selective pressure of high‐altitude environments. The analysis highlights the idea that noncoding sequences may be promising elements in facilitating the rapid evolution and adaptation to high altitudes.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Tfs Control Gene Expression Divergence By a Genetic Regulato...mentioning

confidence: 99%

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Divergent contributions of coding and noncoding sequences to initial high‐altitude adaptation in passerine birds endemic to the Qinghai–Tibet Plateau

et al. 2023

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“…Cells employ a diverse repertoire of transcriptional regulatory proteins to finely modulate gene expression [ 32 ]. Studies have established the crucial role of recognizing post-translational modifications of histones in transcriptional regulation [ 112 ].…”

Section: Continued Research On Gas41mentioning

confidence: 99%

“…Notably, the aromatic amino acids W93, F96, and Y74 play a central role in the representative structure of the GAS41-YEATS-H3K27ac complex [ 30 , 31 ]. Intriguingly, GAS41 has been characterized as a novel oncogene with indications of aberrant amplification in various cancers [ 32 ]. Importantly, GAS41 has been found to target downstream regulators such as Zinc finger E-box-binding homeobox 1 (ZEB1) [ 33 ], transforming acidic coiled-coil 1 (TACC) [ 34 ], and (Transcription elongation factor A protein 1) TCEA1 [ 35 ] to modulate cancer progression (Fig.…”

Section: Introductionmentioning

confidence: 99%

Unveiling the role of GAS41 in cancer progression

Ji,

Li,

Liu

et al. 2023

Cancer Cell Int

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GAS41, a member of the human YEATS domain family, plays a pivotal role in human cancer development. It serves as a highly promising epigenetic reader, facilitating precise regulation of cell growth and development by recognizing essential histone modifications, including histone acetylation, benzoylation, succinylation, and crotonylation. Functional readouts of these histone modifications often coincide with cancer progression. In addition, GAS41 functions as a novel oncogene, participating in numerous signaling pathways. Here, we summarize the epigenetic functions of GAS41 and its role in the carcinoma progression. Moving forward, elucidating the downstream target oncogenes regulated by GAS41 and the developing small molecule inhibitors based on the distinctive YEATS recognition properties will be pivotal in advancing this research field.

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