2001
DOI: 10.1086/321276
|View full text |Cite
|
Sign up to set email alerts
|

Multifactor-Dimensionality Reduction Reveals High-Order Interactions among Estrogen-Metabolism Genes in Sporadic Breast Cancer

Abstract: One of the greatest challenges facing human geneticists is the identification and characterization of susceptibility genes for common complex multifactorial human diseases. This challenge is partly due to the limitations of parametric-statistical methods for detection of gene effects that are dependent solely or partially on interactions with other genes and with environmental exposures. We introduce multifactor-dimensionality reduction (MDR) as a method for reducing the dimensionality of multilocus informatio… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

16
1,640
1
11

Year Published

2003
2003
2018
2018

Publication Types

Select...
9

Relationship

3
6

Authors

Journals

citations
Cited by 1,747 publications
(1,686 citation statements)
references
References 29 publications
16
1,640
1
11
Order By: Relevance
“…For testing the epistatic interaction between pairs of SNPs, multifactor dimensionality reduction (MDR) was applied (Moore, 2004; Ritchie et al., 2001). This methodology can reveal high‐order interactions among genes collaborating with respect to a given phenotype, with the aim of determining multilocus genotype combinations associated with high or low risk of disease.…”
Section: Methodsmentioning
confidence: 99%
“…For testing the epistatic interaction between pairs of SNPs, multifactor dimensionality reduction (MDR) was applied (Moore, 2004; Ritchie et al., 2001). This methodology can reveal high‐order interactions among genes collaborating with respect to a given phenotype, with the aim of determining multilocus genotype combinations associated with high or low risk of disease.…”
Section: Methodsmentioning
confidence: 99%
“…The evaluation of gene-gene interactions was also performed using the open-source MDR software package 53,54 (v.1.1.0; available at: http://www.epistasis.org). The MDR constructive induction algorithm provides an exhaustive search of all possible combinations of two to four variables.…”
Section: Multivariate Analysismentioning
confidence: 99%
“…For both the family-based and the case-control datasets, the multifactor dimensionality reduction (MDR) method was used to detect gene-gene interactions Moore JH, 2007;Moore JH et al, 2006;Ritchie MD et al, 2001). MDR is a nonparametric and genetic model-free method that uses constructive induction to change the representation space of the data to make nonadditive interactions easier to detect using classification methods such as naïve Bayes or logistic regression.…”
Section: Resultsmentioning
confidence: 99%