Multifactorial Assessment of Motor Behavior in Rats after Unilateral Sciatic Nerve Crush Injury

Knörr, Susanne; Rauschenberger, Lisa; Lang, Tami; Volkmann, Jens; Ip, Chi Wang

doi:10.3791/62606-v

Cited by 1 publication

(1 citation statement)

References 2 publications

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“…In contrast, the parameter "intermediate toe spread" was distinctive to the SNI model. However, in some cases it was decreased (Knorr et al, 2021) and in others increased (Okuwa et al, 2018), maybe due to differences in the SNI models. This phenotype highlights the potential use of toe spread as a core parameter for assessing SNI-related gait dysfunction or testing novel therapies.…”

Section: Discussionmentioning

confidence: 96%

CatWalk XT gait parameters: a review of reported parameters in pre-clinical studies of multiple central nervous system and peripheral nervous system disease models

Timotius¹,

Roelofs²,

Richmond-Hacham³

et al. 2023

Front. Behav. Neurosci.

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Automated gait assessment tests are used in studies of disorders characterized by gait impairment. CatWalk XT is one of the first commercially available automated systems for analyzing the gait of rodents and is currently the most used system in peer-reviewed publications. This automated gait analysis system can generate a large number of gait parameters. However, this creates a new challenge in selecting relevant parameters that describe the changes within a particular disease model. Here, for the first time, we performed a multi-disorder review on published CatWalk XT data. We identify commonly reported CatWalk XT gait parameters derived from 91 peer-reviewed experimental studies in mice, covering six disorders of the central nervous system (CNS) and peripheral nervous system (PNS). The disorders modeled in mice were traumatic brain injury (TBI), stroke, sciatic nerve injury (SNI), spinal cord injury (SCI), Parkinson’s disease (PD), and ataxia. Our review consisted of parameter selection, clustering, categorization, statistical evaluation, and data visualization. It suggests that certain gait parameters serve as potential indicators of gait dysfunction across multiple disease models, while others are specific to particular models. The findings also suggest that the more site-specific the injury is, the fewer parameters are reported to characterize its gait abnormalities. This study strives to present a clearly organized picture of gait parameters used in each one of the different mouse models, potentially helping novel CatWalk XT users to apply this information to similar or related mouse models they are working on.

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Section: Discussionmentioning

confidence: 96%