Multifactorial causes of irritating bladder symptoms in patients with sjögren's syndrome

Lee, Kuang Lun; Dong, Chung Shiu; Chen, Mao Yuan; Ho, Chen Hsun; Tai, Huai‐Ching; Hung, Shun Fa; Hong, Yuling

doi:10.1002/nau.20887

Cited by 9 publications

(6 citation statements)

References 30 publications

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“…They observed that 87% of the patients had frequency, 66% nocturia and 52% urgency. Defining polyuria as total daily urine output more than 3,000 mL, they noted polyuria in four patients (17%) based upon the voiding diary; average voided volume was 294 mL [17]. However we observed no polyuria in our patients.…”

Section: Discussioncontrasting

confidence: 58%

Increased Overactive Bladder Symptoms in Primary Sjogren’s Syndrome

Tarhan

2013

World J Nephrol Urol

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Background:Urinary system involvement is a well-known extraglandular manifestation in primary Sjogren's syndrome (pSS). The term "Overactive Bladder" (OAB) is used to define the symptom complex of urinary urgency, generally accompanied by nocturia, with or without urinary incontinence, in the absence of urinary tract infection or other obvious pathologies. In our study, the frequency of OAB was investigated in patients with pSS and compared with the frequency observed in normal healthy controls (NHC). Methods:In this cross-sectional study, 50 patients with pSS and 44 NHC were included. For all the participants, the forms of OAB-Validated 8-question Awareness Tool (OAB-V8) and 3-day voiding diary were completed. The diagnosis of OAB was made in the presence of OAB-V8 scores higher than 8. The 3-day means of the parameters in the voiding diary form were calculated and recorded. Results:The rate of OAB was found to be 56% in patients with pSS, while it was 22.7% in the NHC group. Comparing the pSS patients with the NHC group, significant differences were observed in terms of mean OAB-V8 score (11.5 ± 8.8; 6.5 ± 5.3 P < 0.05), daytime frequency (8.4 ± 3.7; 3.6 ± 2.6 P < 0.05) and nocturia (2.2 ± 1.24; 1.2 ± 1.1 P < 0.05). No incontinence was observed in any patients. Conclusion:OAB was encountered more frequently in pSS patients than in the NHC group. Since OAB is a treatable symptom complex, it should not be ignored, and symptoms of OAB should always be searched in pSS patients.

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Section: Discussioncontrasting

confidence: 58%

Increased Overactive Bladder Symptoms in Primary Sjogren’s Syndrome

Tarhan

2013

World J Nephrol Urol

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“…Moreover, xerostomia, a cardinal symptom of pSS patients, may lead to excessive water intake, and consequently associated with OAB symptoms. [12]…”

Section: Discussionmentioning

confidence: 99%

Overactive bladder and bladder pain syndrome/interstitial cystitis in primary Sjögren’s syndrome patients: A nationwide population-based study

et al. 2019

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To investigate the risks of overactive bladder (OAB) and bladder pain syndrome/interstitial cystitis (BPS/IC) in primary Sjögren’s syndrome (pSS) patients. A nationwide, population-based cohort study was conducted using data from Taiwan’s National Health Insurance Research Database. From 2001 to 2010, participants with newly diagnosed pSS were recognized as the study group. In addition, a comparison cohort of non-pSS participants was matched for age, gender, and initial diagnosis date. Risks of developing OAB and BPS/IC in pSS patients of different age, sex, and various therapeutic strategies were calculated. Hazard ratios (HR) and a 95% confidence interval (CI) were analyzed by Cox proportional hazard model. In total, 11,526 pSS patients were recognized. The HRs of OAB and BPS/IC in pSS patients were 1.68 (95% C.I.: 1.48–1.91, p<0.01) and 2.34 (95% C.I.: 1.59–3.44, p<0.01), respectively. The risks of OAB and BPS/IC were significantly increased for pSS patients aged < 65 years (HR: 1.73 and 2.67), female patients (HR: 1.74 and 2.34), and patients requiring treatment for dry eyes and dry mouth (HR: 2.06 and 2.93). pSS patients exhibited an increased risk of OAB and BPS/IC. Female gender, younger age, and severe glandular dysfunction requiring treatments were potential risk factors.

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“…5 Primary Sjo¨gren syndrome (pSS) patients are likely to present both with OAB symptoms (frequency, nocturia, urgency) and urodynamic abnormalities (such as detrusor overactivity) although further studies are needed to confirm these findings. 6 Case reports on this subject often reveal severe cases of bladder involvement requiring aggressive immunosuppressive treatment strategies. 7 Lupus cystitis has been described as a possible manifestation of systemic lupus erythematosus (SLE), and in a recent large, retrospective study it was strongly associated with lupus mesenteric vasculitis and poorer disease outcomes.…”

Section: Introductionmentioning

confidence: 99%

Overactive bladder symptom bother and health-related quality of life in patients with systemic lupus erythematosus and primary Sjögren syndrome

Silva

Romão

Neves

et al. 2018

Lupus

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Objective The objective of this paper is to assess overactive bladder (OAB) symptom bother (SB) and health-related quality of life (HRQL) among patients with systemic lupus erythematosus (SLE) and primary Sjögren syndrome (pSS). Methods We recruited adult SLE and pSS patients and two groups of age- and sex-matched controls. We applied the OAB questionnaire-short form (OABq-SF) to all participants to assess SB and HRQL and collected clinical information relevant for OAB. We compared the OABq-SF scores for SB and HRQL between patients and controls using univariate and multivariate linear regression analysis. Results We recruited 95 rheumatic patients (68 SLE, 27 pSS) and 231 controls. Compared to controls SLE patients showed higher OABq-SF SB scores (22.6 ± 20.4 vs 14.7 ± 17.0, p = 0.004) and lower HRQL scores (89.8 ± 15.8 vs 93.8 ± 11.4, p = 0.044). On multivariate analysis SLE was significantly associated with a higher SB score (ß-coefficient 7.13, p = 0.008) and tended to be associated with worse HRQL values (ß-coefficient –3.53, p = 0.055). Patients with pSS had numerically higher mean SB scores (22.8 ± 22.5 vs 16.2 ± 18.0, respectively, p = 0.107) and lower HRQL scores (91.0 ± 10.7 vs 93.2 ± 11.6, respectively, p = 0.369), although these differences were not statistically significant. Diagnosis of pSS was not significantly associated with SB or HRQL scores on univariate or multivariate analysis. Conclusions Patients with SLE have significantly worse OAB-SB and poorer HRQL compared to controls. A similar trend was seen for pSS patients, especially for SB. These findings suggest that clinically subtle OAB symptoms may be present in rheumatic patients for whom, later on, bladder pain syndrome may occur.

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Multifactorial causes of irritating bladder symptoms in patients with sjögren's syndrome

Abstract: Various factors contribute to the irritating bladder symptoms in patients with SS, with DO being predominant. The LUTS developed in patients with SS are not due to any specific single etiology and that each patient must be individually carefully evaluated.

Cited by 9 publications

References 30 publications

Increased Overactive Bladder Symptoms in Primary Sjogren’s Syndrome

Increased Overactive Bladder Symptoms in Primary Sjogren’s Syndrome

Overactive bladder and bladder pain syndrome/interstitial cystitis in primary Sjögren’s syndrome patients: A nationwide population-based study

Overactive bladder symptom bother and health-related quality of life in patients with systemic lupus erythematosus and primary Sjögren syndrome

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