Multifactorial pathways in burn injury-induced chronic pain: novel targets and their pharmacological modulation

Roy, Tapas Kumar; Uniyal, Ankit; Tiwari, Akhilesh Vinod

doi:10.1007/s11033-022-07748-9

Cited by 6 publications

(2 citation statements)

References 112 publications

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“…Burn trauma and burn wounds are the most challenging and longest-healing traumas [6]. Consequences and the severity of the treatment depend on the degree and extent of burns; they can be from mild, which does not require physicians' intervention, to very severe, including death in their course [7][8][9]. Patients may experience electrolyte imbalance, metabolic disturbances, lowering protein level, loss of body weight, and infection complications-local concerning burn wounds or (because of immunosuppression induced by the trauma) generalised infections and sepsis with multiorgan disturbances, renal, heart, and respiratory failure-which may lead to death [10].…”

Section: Discussionmentioning

confidence: 99%

“…However, the use of methadone in burn patients is limited to retrospective studies [19]. The data clearly show that opioid use requires careful assessment of the patient's tolerance and ongoing titration of these medications, as the reason varies in different patients [8,9,[20][21][22]. In burn patients, pharmacogenetic polymorphism has been clearly associated with differences in opioid use [23,24].…”

Section: Discussionmentioning

confidence: 99%

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Analgesic Efficacy of Oxycodone in Postoperative Dressings after Surgical Treatment of Burn Wounds: A Randomised Controlled Trial

Kowalski,

Leppert,

Domagalska

et al. 2024

JCM

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Introduction: This study aimed to assess the analgesic efficacy of oxycodone at doses of 10 mg and 20 mg in dressings after surgery of burn wounds. Material and Methods: Twenty adult patients who underwent surgical treatment of third-degree burn wounds under general anaesthesia were included. Burn wounds were treated with dressings, to which oxycodone was added at 20 mg in Group 1 and 10 mg in Group 2. After the surgery, plasma oxycodone and noroxycodone concentrations were assayed, and pain intensity was assessed with Numerical Rating Scale (NRS). Results: In Group 1, no patient reported pain; in Group 2, four patients reported pain. The pain intensity, according to NRS, was 1–8. Plasma concentration of oxycodone in the blood serum was in the range of 1.24–3.15 ng/mL and 1.09–1.28 ng/mL in Group 1 and Group 2, respectively. Noroxycodone was not detected in the plasma. Adverse effects were not observed in any of the treated patients. Conclusions: Oxycodone in dressings provides patients with adequate and safe analgesia.

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