Multifactorial sleep disturbance in Parkinson's disease

Albers, Jan; Chand, Pratap; Anch, A. Michael

doi:10.1016/j.sleep.2017.03.026

Cited by 73 publications

(67 citation statements)

References 90 publications

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“…Moderate associations were found between the PDSS‐2 and the SCOPA‐Motor ADL, complications section, and its total score, as well as between the PDSS‐2 and the CISI‐PD, suggesting that motor problems and disability may have some effect on sleep‐related issues in PD . In fact, nocturnal hypokinesia has recently been highlighted as an important factor impairing sleep quality …”

Section: Discussionmentioning

confidence: 99%

“…7 Moderate associations were found between the PDSS-2 and the SCOPA-Motor ADL, complications section, and its total score, as well as between the PDSS-2 and the CISI-PD, suggesting that motor problems and disability may have some effect on sleeprelated issues in PD. 8,50 In fact, nocturnal hypokinesia has recently been highlighted as an important factor impairing sleep quality. 51 Although PD duration and LEDD were not significant predictors of PDSS-2 total scores, patient groups with longer PD duration and higher LEDD scored significantly higher on the PDSS-2 than those with shorter PD duration and lower LEDD, suggesting that problems with sleep could worsen with disease progression.…”

Section: Discussionmentioning

confidence: 99%

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Relationship of Nocturnal Sleep Dysfunction and Pain Subtypes in Parkinson's Disease

Martinez‐Martín

Rizos

Wetmore

et al. 2018

Movement Disord Clin Pract

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Background Little research has been conducted regarding the relationship between sleep disorders and different pain types in Parkinson's disease (PD). Objective To explore the influence of the various pain subtypes experienced by PD patients on sleep. Methods Three hundred consecutive PD patients were assessed with the PD Sleep Scale‐Version 2 (PDSS‐2), King's PD Pain Scale (KPPS), King's PD Pain Questionnaire (KPPQ), Visual Analog Scales for Pain (VAS‐Pain), and Hospital Anxiety and Depression Scale. Results According to the PDSS‐2, 99.3% of our sample suffered from at least one sleep issue. Those who reported experiencing any modality of pain suffered significantly more from sleep disorders than those who did not (all, P < 0.003). The PDSS‐2 showed moderate‐to‐high correlations with the KPPS (rS = 0.57), KPPQ (0.57), and VAS‐Pain (0.35). When PDSS‐2 items 10 to 12 (pain‐related) were excluded, the correlation values decreased to 0.50, 0.51, and 0.28, respectively, while these items showed moderate‐to‐high correlations with KPPS (0.56), KPPQ (0.54), and VAS‐Pain (0.42). Among the variables analyzed, multiple linear regression models suggested that KPPS and KPPQ were the most relevant predictors of sleep disorders (as per the PDSS‐2), although following exclusion of PDSS‐2 pain items, depression was the relevant predictor. Depression and anxiety were the most relevant predictors in the analysis involving the VAS‐Pain. Regression analysis, considering only the KPPS domains, showed that nocturnal and musculoskeletal pains were the best predictors of overall nocturnal sleep disorder. Conclusions Pain showed a moderate association with nocturnal sleep dysfunction in PD. Some pain subtypes had a greater effect on sleep than others.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Relationship of Nocturnal Sleep Dysfunction and Pain Subtypes in Parkinson's Disease

Martinez‐Martín

Rizos

Wetmore

et al. 2018

Movement Disord Clin Pract

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“…time spent in work-related physical activity, active travel, leisure time physical activity) are differently related to the presence of sleep disturbances. Although we included a wide variety of important chronic conditions, we lacked data on other chronic conditions such as migraine [63] and Parkinson's disease [64], which could have been associated with both sleep problems and altered levels of physical activity. Other factors such as pregnancy [65] or medication use, which may contribute to sleep disturbances or affect levels of physical activity was not considered due to lack of data.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Physical activity and sleep problems in 38 low- and middle-income countries

et al. 2018

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“…The impact of nonmotor symptoms of Parkinson’s disease (PD) on patients’ quality of life is comparable to the impact of the characteristic motor symptoms of PD. 1 , 2 Sleep disturbances are one of the major nonmotor complaints, and they often manifest even before the clinical onset of PD. 2 , 3 These sleep problems may worsen with disease progression and deterioration of motor-related abilities.…”

Section: Introductionmentioning

confidence: 99%

“… 4 – 6 It is estimated that 74%–98% of patients exhibit symptoms of sleep disturbances, including insomnia, abnormal movements during sleep (eg, periodic leg movements and rapid eye movement sleep behavior disorders), and excessive daytime sleepiness. 1 , 6 However, sleep disturbances are often overlooked in clinical settings and are poorly examined in PD research.…”

Section: Introductionmentioning

confidence: 99%

Comparison of nocturnal symptoms in advanced Parkinson’s disease patients with sleep disturbances: pramipexole sustained release versus immediate release formulations

Xiang¹,

Sun²,

Teoh³

2018

DDDT

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BackgroundNocturnal symptoms are common in Parkinson’s disease (PD), which greatly affect the quality of life but are often overlooked in clinical settings. Treatment strategies that provide sustained dopaminergic stimulation may have sleep benefits.ObjectiveTo investigate the treatment effects of pramipexole (PPX) sustained release (SR) versus PPX immediate release (IR) on nocturnal symptoms in advanced PD patients with sleep disturbances.Materials and methodsIn this study, the PPX clinical trial (NCT00466167) was retrospectively analyzed for PD Sleep Scale (PDSS) total and domain scores in patients with advanced idiopathic PD receiving either PPX SR or PPX IR, who experienced motor fluctuations while on stable levodopa with a baseline PDSS total score of <90, indicating sleep disturbances. Analysis of covariance test was used to compare the adjusted mean changes at week 18 from baseline between treatment groups, after adjusting for pooled country and baseline scores.ResultsA total of 119 patients with PD reported sleep disturbances at baseline (PDSS <90; SR, n=59; IR, n=60). At week 18, patients receiving PPX SR reported numerically greater improvement of sleep disturbance than those receiving PPX IR, although the difference of 6.8 points was not statistically significant (adjusted mean changes in PDSS total score, SR=28.5 versus IR=21.7 points, P=0.165). Patients receiving PPX SR observed a numerically greater adjusted mean change in all PDSS domains compared with PPX IR. The overall proportions of patients with any adverse event were similar between both PPX SR and IR groups (62.7% versus 70.0%).ConclusionBoth the PPX formulations showed improvements in nocturnal symptoms in advanced PD patients with sleep disturbances and were generally well tolerated. Given the known pharmacokinetic profile of an SR formulation and numerical advantage in PDSS mean change over IR formulation, these preliminary evidences support future prospectively designed studies to investigate the effects of PPX SR for improved sleep.

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Multifactorial sleep disturbance in Parkinson's disease

Cited by 73 publications

References 90 publications

Relationship of Nocturnal Sleep Dysfunction and Pain Subtypes in Parkinson's Disease

Relationship of Nocturnal Sleep Dysfunction and Pain Subtypes in Parkinson's Disease

Physical activity and sleep problems in 38 low- and middle-income countries

Comparison of nocturnal symptoms in advanced Parkinson’s disease patients with sleep disturbances: pramipexole sustained release versus immediate release formulations

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Multifactorial sleep disturbance in Parkinson's disease

Cited by 73 publications

References 90 publications

Relationship of Nocturnal Sleep Dysfunction and Pain Subtypes in Parkinson's Disease

Relationship of Nocturnal Sleep Dysfunction and Pain Subtypes in Parkinson's Disease

Physical activity and sleep problems in 38 low- and middle-income countries

Comparison of nocturnal symptoms in advanced Parkinson&rsquo;s disease patients with sleep disturbances: pramipexole sustained release versus immediate release formulations

Contact Info

Product

Resources

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Comparison of nocturnal symptoms in advanced Parkinson’s disease patients with sleep disturbances: pramipexole sustained release versus immediate release formulations