Multifluorescently Traceable Nanoparticle by a Single-Wavelength Excitation with Color-Related Drug Release Performance

Abstract

Monodisperse and nanometer-sized periodic mesoporous organosilicas co-doped with fluorescence resonance energy transfer cascades composed of triple fluorophores at various ratios were prepared. These nanoparticles exhibit multifluorescent emissions by a single-wavelength excitation and were designed for the application as multichannelly traceable drug carriers. Different from the hydrophilic framework of inorganic mesoporous silica and hydrophobic framework of mesoporous carbon, these multifluorescent nanoparticles have intrinsically different and finely tunable pore surface polarities governed by the type and amount of fluorophore inside the framework. When applied as drug carriers, they can achieve synchronous or asynchronous release of different drugs by simply choosing different colored nanoparticles. These colorful mesoporous composites with finely tunable color-related drug release performance provide a strong barcoding system for the potential applications of fluorescent nanoparticles in effective screening of drugs and therapeutic protocols for diseases.

Periodic mesoporous organosilicas for advanced applications

“…[14][15][16][17] For example, Thiel and co-workers 15 generated a PMO material that successfully combined two antagonistic functional groups in a single PMO material, that is, one type of functional group was located in the framework walls and another functional group was directed to the pore channels. The resulting materials possess a hydrophobic phenylene layer and a hydrophilic propylamine layer.…”

“…The obtained material possesses molecular periodicity even with higher loading of the thiol functional precursor (67 mol % in the initial reaction mixture). Zhang and co-workers 16 synthesized nanometer-sized PMO materials using bridged organosilane precursors with three types of different functional groups (fluorophores) located in the mesopore walls. The obtained materials show multifluorescent emission by single-wavelength excitation.…”

Facile Synthesis of Yolk–Shell Structured Inorganic–Organic Hybrid Spheres with Ordered Radial Mesochannels

“…It is reported that the integration of organic and inorganic fragments can endow the obtained hybrid materials with mechanical stability, hydrothermal stability, tailored surface polarities, and even good biocompatibility for different applications, such as catalysis, energy conversion, drug delivery, and so on. [34][35][36][37][38] However, to the best of our knowledge, there is no report about synthesizing yolk-shell spheres in which the core and shell are made of inorganic-organic hybrid material. Overall, it remains a grand challenge to fabricate monodisperse yolk-shell structures with tunable size, accessible ordered mesochannels, inorganicorganic hybrid framework by a facile approach.…”

Chemistry of Mesoporous Organosilica in Nanotechnology: Molecularly Organic–Inorganic Hybridization into Frameworks

“…[ 286 ] Bissilylated organosilica precursors, including biphenyl (Biph) ( R 1 ), anthracene (Anth) ( R 2 ), and naphthalimide (Naph) ( R 3 ), were initially synthesized via different chemical reactions ( Figure 28 a), which were further co-condensed with TEOS to form MONs with fl uorescent frameworks. Excited by single-wavelength light, these MONs showed multifl uorescent emission because of the consecutive FRET processes among Biph, Anth, and Naph (Figure 28 b).…”