Multifocal Analysis of Acute Pain After Third Molar Removal

Weckwerth, Giovana Maria; Dionísio, Thiago José; Costa, Yuri Martins; Zupelari-Gonçalves, Paulo; Oliveira, Graça; Torres, Elza Araujo; Bonjardim, Leonardo Rigoldi; Faria, Flávio Augusto Cardoso de; Calvo, Adriana Maria; Moore, Troy; Absher, Devin; Santos, Carlos

doi:10.3389/fphar.2021.643874

Cited by 6 publications

(3 citation statements)

References 44 publications

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“…Hence, it is unlikely we had enough power to detect a possible association between this variant and periodontitis in self-reported Black individuals. A mechanism by which this functional SNP could explain the protective effect toward having periodontitis would be through the higher affinity for beta-endorphin, which participates in regulating the secretion of pro-inflammatory cytokines from periphery immune cells [ 33 ]. Furthermore, immune response and inflammation pathways, such as those involving cytokine and chemokine activities, have been reported to be the most upregulated in RNA expression analysis of affected tissues from individuals with periodontitis [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

Pain perception genes, asthma, and oral health: A reverse genetics study

Lisboa

Sekula²,

Bezamat³

et al. 2022

PLoS ONE

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Pain is an experience of a subjective nature, interpreted in a personal way and according to an extensive palette of factors unique to each individual. Orofacial pain can be acute or chronic and it is usually the main reason for the patient to seek dental care. Pain perception varies widely among individuals. This variability is considered a mosaic of factors, which include biopsychosocial factors and genetic factors. Understanding these differences can be extremely beneficial for pain management in a personalized and more efficient way. We performed association studies to investigate phenotypes associated with genetic markers in pain-related genes in two groups of patients who received more or less anesthesia during dental treatment. The study group was comprised of 1289 individuals participating in the Dental Registry and DNA Repository Project (DRDR) of the University of Pittsburgh, with 900 participants in the group that received the most anesthesia and 389 constituting the comparison group that received less anesthesia. We tested 58 phenotypes and genotypic data of seven SNPs in genes that are associated with pain perception, pain modulation and response to drugs used in pain treatment: COMT (rs4818 and rs6269), GCH1 (rs3783641), DRD2 (rs6276), OPRM1 (rs1799971), SCN9A (rs6746030) and SCN10A (rs6795970). The analysis revealed a protective effect of rs1799971 on asthma in the total sample. rs3783641 was associated with salivary secretion disorders in females who received more anesthesia. rs1799971 was also associated with periodontitis in Whites who received less anesthesia. rs4818 was associated with disease and other tongue conditions in the group composed of Blacks who received less anesthesia. In conclusion, our study implicated variants in pain-related genes in asthma and oral phenotypes.

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Section: Discussionmentioning

confidence: 99%

Pain perception genes, asthma, and oral health: A reverse genetics study

Lisboa

Sekula²,

Bezamat³

et al. 2022

PLoS ONE

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“…In another prospective cohort, OPRM1 and COMT SNPs were not correlated with APSP intensity after third molar removal. 105 This inconsistency in results was possibly caused by the difference in the predictive gene allele for different surgeries.…”

Section: Genetic Factorsmentioning

confidence: 99%

Risk Factors for Acute Postsurgical Pain: A Narrative Review

Liu,

Dai,

et al. 2024

JPR

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Acute postsurgical pain (APSP) has received growing attention as a surgical outcome. When poorly controlled, APSP can affect short-and long-term outcomes in patients. Despite the steady increase in awareness about postoperative pain and standardization of pain prevention and treatment strategies, moderate-to-severe APSP is frequently reported in clinical practice. This is possibly because pain varies widely among individuals and is influenced by distinct factors, such as demographic, perioperative, psychological, and genetic factors. This review investigates the risk factors for APSP, including gender, age, obesity, smoking history, preoperative pain history, pain sensitivity, preoperative anxiety, depression, pain catastrophizing, expected postoperative pain, surgical fear, and genetic polymorphisms. By identifying patients having an increased risk of moderate-to-severe APSP at an early stage, clinicians can more effectively manage individualized analgesic treatment protocols with a combination of pharmacological and nonpharmacological interventions. This would alleviate the transition from APSP to chronic pain and reduce the severity of APSPinduced chronic physical disability and social psychological distress. Keywords: acute postoperative pain, acute postsurgical pain, risk factors, predictors which 86% reported moderate, severe, or extreme pain. 8 When poorly controlled, APSP can prolong hospital stay, increase opioid use, and contribute to health care costs. 9,10 Additionally, APSP is correlated with poor prognosis including postoperative delirium, cardiovascular events, thromboembolism, pulmonary complications, and chronic pain syndrome. [11][12][13][14][15] Although the interest in APSP is growing in the recent decades, effective pain management is a clinical challenge. 8,16 Identifying patients with high APSP-related risk factors on the basis of individual differences in patients' social, psychological, and genetic factors is essential for the early prevention and individualized treatment of APSP.APSP-related risk factors vary according to the surgery type. Ip et al 17 were the first to systematically review APSP predictors. They found that preoperative pain, anxiety, age, and surgery type were the four most significant predictors of APSP. Sobol-Kwapinska et al 18 reviewed APSP-related psychological factors and noted the probable association between APSP and anxiety, pain catastrophizing, expectation of pain, and depression. On conducting a systematic review of literature on pain sensitivity for predicting APSP, Werner et al 19 observed that the predictive strength of pain sensitivity is

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“…Weckwerth et al (2021) исследован уровень содержания фактора некроза опухоли в естественной биологической среде полости рта у лиц с острой болью после операции сложного атипичного удаления третьего моляра. Авторами на достаточном клинико-лабораторном материале объективно доказано, что степень послеоперационного отека и выраженность послеоперационной воспалительной контрактуры жевательных мышц могут быть прогнозируемы на основании уровня содержания ФНО в ротовой жидкости [27].…”

Section:  результаты и обсуждениеunclassified

Up-to-date Information on Tumor Necrosis Factor in Oral Fluid of Patients with Third Molars in Oral Cavity and in Patients with Traumatic Fractures of Lower Jaw. Literature Review

Pohodenko-Chudakova¹,

Али²

2022

Стоматология. Эстетика. Инновации

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Цель. На основании анализа сведений, представленных в специальной литературе, содержащих как экспериментальную, так и клиническую составляющие при исследовании вопросов определения фактора некроза опухоли (ФНО) в биологических средах организма, в том числе в ротовой жидкости (РЖ) у лиц с третьими молярами в полости рта и у пациентов с травматическими переломами нижней челюсти, выявить нерешенные задачи и определить направление дальнейшего исследования. Материалы и методы. Проведен анализ специальной литературы за последние 15 лет по вопросам определения ФНО в биологических средах организма, в том числе в РЖ у лиц с третьими молярами в полости рта и у пациентов с травматическими переломами нижней челюсти. Результаты. Выявлены единичные публикации, содержащие результаты анализа уровня содержания ФНО в РЖ у лиц с третьими молярами. Исследован уровень содержания ФНО в естественной биологической среде полости рта у лиц с острой болью после операции удаления третьего моляра; доказано, что послеоперационный отек и воспалительная контрактура жевательных мышц могут быть прогнозируемы на основании уровня содержания ФНО в РЖ. С учетом того, что присутствие третьих моляров в большинстве клинических ситуаций сопровождается воспалительно-деструктивными процессами, чаще поражениями периодонта, важными являются данные об уровне содержания ФНО в РЖ, провоцирующего процесс деструкции костной ткани путем активации остеокластической резорбции. Заключение. Изложенное обосновывает необходимость проведения исследования по определению уровня содержания ФНО в ротовой жидкости у пациентов с травматическими переломами нижней челюсти при наличии в полости рта третьих моляров и при их отсутствии. Purpose. To identify unsolved problems and determine the ways of the study according to the analysis of the information presented in the specialized literature containing experimental and clinical parts in the study of the issues of determining the tumor necrosis factor (TNF) in biological environments of the body, including in the oral fluid (OF) in patients with third molars in the oral cavity and in patients with traumatic fractures of the mandible. Materials and methods. The analysis of special literature for the last 15 years on the determination of TNF in biological environments of the body including in the OF in patients with third molars in the oral cavity and in patients with traumatic fractures of the lower jaw. Results. Few publications containing the results of the analysis of the level of TNF content in the RV in persons with third molars have been identified. The level of TNF content in the natural biological environment of the oral cavity was studied in patients with acute pain after surgery for the third molar removal and it was proved that postoperative edema and inflammatory contracture of the masticatory muscles can be predicted based on the level of TNF content in the OF. Taking into account that the presence of third molars in most clinical cases is accompanied by inflammatory and destructive processes, more often by periodontal lesions, data on the level of TNF content in the OF provoking the process of destruction of bone tissue by activating osteoclastic resorption are important. Conclusion. The mentioned above confirms the need to make a study to determine the mentioned indicator in patients with traumatic fractures of the lower jaw in the presence of third molars in the oral cavity and in their absence.

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Multifocal Analysis of Acute Pain After Third Molar Removal

Cited by 6 publications

References 44 publications

Pain perception genes, asthma, and oral health: A reverse genetics study

Pain perception genes, asthma, and oral health: A reverse genetics study

Risk Factors for Acute Postsurgical Pain: A Narrative Review

Up-to-date Information on Tumor Necrosis Factor in Oral Fluid of Patients with Third Molars in Oral Cavity and in Patients with Traumatic Fractures of Lower Jaw. Literature Review

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