Multifocal cerebellar liponeurocytoma

Scoppetta, Thiago Luiz Pereira Donoso; Brito, Mariana Carneiro Barbosa de; Prado, José Luiz Masson de Almeida; Scoppetta, Luiz Carlos Donoso

doi:10.1212/wnl.0000000000002156

Cited by 12 publications

(6 citation statements)

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“…The brain tumor often affected adults and occasionally involved children, only 2 patients below 20 years old were reported previously [14,47]. The tumors were usually solitary, but multifocal lesions were also reported [34,54,60,61].…”

Section: Discussionmentioning

confidence: 99%

Surgical management and clinical outcomes of cerebellar liponeurocytomas-a report of 7 cases and a pooled analysis of individual patient data

Zuo

Sun

et al. 2021

Preprint

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Objective Cerebellar liponeurocytomas (CLPNs) are very rare. Limited studies described this disease and their treatment protocol remain unclear. To better understand the disease, we review the clinical features and outcomes, and propose a treatment protocol based on previously reported cases and cases from our institute. Methods The clinical data were obtained from 7 patients with pathologically confirmed CLPNs, who accepted surgical treatment in our institute between November 2011 and June 2021. We also reviewed the literature and 75 patients with CLPNs were identified between September 1993 and June 2021. Risk factors for Progression-free survival (PFS) were evaluated in the pooled cohort. Results The authors’ cohort included 4 males and 3 females with a mean age of 43.9±14.5 (range: 29-64 years). 3 cases are located in lateral ventricle and 4 cases are located in cerebellum. All 7 cases achieved gross total resection (GTR) and radiotherapy was administered to 2 cases. After a mean follow-up of 44.9±44.4 months, all patients remained well with no recurrence or death. For the reported 75 patients, there are 35 males and 40 females with a mean age of 46.2±13.6 years (range: 6-77 years). Biopsy, gross total resection (GTR) and non-GTR were achieved in 1 (1.3%), 50 (66.7%), and 24 (32%) patients, respectively. Radiotherapy was administered to 16 cases and chemotherapy was administered to only 1 case. After a mean follow-up of 47.5±51.5 months, 3 patients died and tumor recurrence occurred in 17 patients. Multivariate Cox analysis revealed that non-GTR predicted a poor PFS (p=0.030). Kaplan-Meier analysis showed that GTR was significantly associated with better PFS (p=0.0084). PFS rates at 1, 5, 10 years were 92.7%, 78.0%, 23.8% respectively. Conclusions Cerebellar liponeurocytomas (CLPNs) are very rare brain tumors. Although they have favorable clinical prognosis, the recurrence is relatively high. GTR should be the first choice and close follow-up is necessary. Postoperative radiotherapy could not improve PFS in this study. A larger cohort is needed to verify our findings.

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Section: Discussionmentioning

confidence: 99%

Surgical management and clinical outcomes of cerebellar liponeurocytomas-a report of 7 cases and a pooled analysis of individual patient data

Zuo

Sun

et al. 2021

Preprint

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“…Una situazione simile è stata osservata per l'indice del giallo, con valori significativamente superiori nelle serie B e C (rispettivamente 19,8 e 22,7) rispetto alla serie A (9,5). L'indice del rosso ha mostrato valori significativamente superiori nella serie B (test), i cui campioni assumevano un colore rosato più acceso N o n -c o m m e r c i a l u s e o n l y (3,4), rispetto alle carni crude (-1,1) e alle carni molto cotte (-0,9), che assumevano un colore molto chiaro. L'esame istologico non ha mostrato particolari differenze fra le serie campionarie per quanto riguarda la disposizione e forma delle fibre muscolari.…”

Section: N O N -C O M M E R C I a L U S E O N L Yunclassified

“…La ricerca e il conteggio dei colifagi somatici sono stati condotti in conformità alla norma ISO 10705-2. I risultati hanno evidenziato la presenza di Norovirus GI nell'80% dei campioni (4,37-5,93 log 10 GC/g); Norovirus GII nel 57% dei campioni (4,48-5,50 log 10 GC/g); Rotavirus nel 73% dei campioni (4,25-5,82 log 10 GC/g); Astrovirus nel 33% dei campioni (3,95 log 10 GC/g); Virus dell'Epatite A ed E sono risultati sempre assenti. I risultati hanno dimostrato che il pretrattamento con PMAxx inibisce completamente il segnale di amplificazione di Norovirus GI e GII, Astrovirus e Rotavirus termicamente inattivati.…”

Section: Diffusione DI Specie Algali Potenzialmente Tossiche In Acque...unclassified

“…Questi risultati suggeriscono un effetto dose-dipendente del siero di latte ovino sulle cellule. Garantire la qualità e la sicurezza è diventata una delle maggiori preoccupazioni per le autorità sanitarie nell'industria alimentare [3]. La qualità degli alimenti si riferisce principalmente a caratteristiche quali il valore nutritivo, il gusto, l'aspetto, la consistenza e l'odore.…”

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“…Sperimentale dell'Umbria e delle Marche "Togo Rosati"; 2 Università degli Studi di Perugia, Dipartimento di medicina Veterinaria;3 Consiglio nazionale delle ricerche, Istituto di scienze delle produzioni alimentari, Italy…”

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XXXII Convegno Nazionale dell’Associazione Italiana Veterinari Igienisti (AIVI) | Maierato-Vibo Valentia, 13-14-15 Settembre 2023

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2023

Ital J Food Safety

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The clinicopathological features of liponeurocytoma

Wang

et al. 2017

Brain Tumor Pathol

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To discuss the clinicopathological features of liponeurocytoma, we retrospectively reviewed three liponeurocytoma cases and compared their immunophenotypes and genotypes with those of similar tumors. Furthermore, we reviewed the literature and compared the similarities and differences between cerebellar and intraventricular liponeurocytomas. Two cerebellar and one intraventricular liponeurocytomas were included in the present study. The liponeurocytomas comprised small tumor cells and lipomatous cells. The tumor cells expressed SYN, MAP-2, and NeuN. One case showed atypical histological features. By reviewing the literature, we found that cerebellar liponeurocytoma tended to be more common in females, whereas the converse was true for intraventricular liponeurocytoma. Compared with cerebellar liponeurocytoma, intraventricular liponeurocytoma was more commonly noted in younger adult patients. A high MIB-1 index (>10%) and incomplete tumor resection might represent adverse prognostic factors in patients with liponeurocytoma. We suggest that 'central liponeurocytoma' should be used to include all putative liponeurocytoma sites. The present study identified several morphological, immunohistochemical, and genetic features that may aid in the differential diagnosis of liponeurocytoma. In addition, surgery should be the preferred treatment, and complete tumor resection should be the goal. Additional cases with long-term follow-up are needed to develop optimal management protocols for liponeurocytoma.

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Multifocal cerebellar liponeurocytoma

Cited by 12 publications

References 2 publications

Surgical management and clinical outcomes of cerebellar liponeurocytomas-a report of 7 cases and a pooled analysis of individual patient data

Surgical management and clinical outcomes of cerebellar liponeurocytomas-a report of 7 cases and a pooled analysis of individual patient data

XXXII Convegno Nazionale dell’Associazione Italiana Veterinari Igienisti (AIVI) | Maierato-Vibo Valentia, 13-14-15 Settembre 2023

The clinicopathological features of liponeurocytoma

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