Multifocal Electroretinography

Mendoza‐Santiesteban, Carlos E.; Fernández-Cherkasova, Lilia; Echavarría, Odelaisys Hernández; Rodríguez, Ramón Cabal; Columbie-Garbey, Yannara; Riesgo, Tamara Juvier

doi:10.3109/08820538.2010.500210

Cited by 5 publications

(3 citation statements)

References 28 publications

(21 reference statements)

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“…These results are in agreement to previous works showing that increased CRT severely impairs luminous sensitivity [26,27] and validates MP as a method to demonstrate functional inner retinal impairment in DMO. We also found that mfERG P1 amplitude was likewise significantly and markedly lower in DMO subjects in all studied rings, with an increase of the implicit time, showing functional outer retina impairment [28]. These results confirm the published literature that showed that P1 amplitudes were significantly decreased in DMO patients [19].…”

Section: Discussionsupporting

confidence: 90%

Microperimetry and mfERG as functional measurements in diabetic macular oedema undergoing intravitreal ranibizumab treatment

Santos

Raimundo

Alves

et al. 2020

Eye

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Purpose To evaluate Microperimetry (MP) and multifocal electroretinogram (mfERG) as whole-macula functional markers of treatment response in naive diabetic macular oedema (DMO) patients undergoing ranibizumab treatment. Methods An exploratory sub-analysis of a prospective study (NCT01947881-CHARTRES). Patients received three monthly ranibizumab injections (loading dose) followed by pro re nata (PRN) regimen during 1 year. At baseline, during and after treatment (Months 0, 3, 6 and 12), subjects were tested using BCVA, OCT, MP and mfERG. MP was performed in the central 12°, and retinal sensitivity was measured overall (mean sensitivity (MS)), and in three concentric rings (R1-R3). mfERG P1 amplitude and implicit time were measured over six concentric rings (R1-R6). Results Thirty-two eyes were included. MP mean and rings sensitivity were significantly lower in DMO (p < 0.001). After loading dose, a significant improvement in retina sensitivity was observed, particularly in good BCVA responders (MS = +2.28 dB; R1 = +2.33 dB, R2 = +2.20 dB, R3 = +2.25 dB; p = 0.049). Overall retinal sensitivity was significantly correlated with BCVA improvement (r = 0.54; p = 0.026) and inversely correlated with OCT central subfield thickness improvement (r = −0.39; p = 0.026). mfERG amplitude and implicit time were also lower in DMO (p < 0.011). An improvement of mfERG P1 amplitude and implicit time in R1 was noted in good responders after ranibizumab loading dose (+16.49 nV/deg 2 ; p = 0.013 and −0.005 ms; p = 0.048, respectively). When changing to PRN treatment regimen, BCVA was maintained during the 12 months of follow-up but worsening of the visual function was detected by MP and mfERG. Conclusions Microperimetry and mfERG were able to demonstrate DMO functional improvement after treatment loading dose, as well as early visual changes when treatment regimen was switched to PRN.

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Section: Discussionsupporting

confidence: 90%

Microperimetry and mfERG as functional measurements in diabetic macular oedema undergoing intravitreal ranibizumab treatment

Santos

Raimundo

Alves

et al. 2020

Eye

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“… 12 Most studies focused on preoperative and postoperative comparisons, with no comparisons with the fellow eyes or normal controls. 7 , 13 , 14 Our results suggested that the delayed implicit time of all the rings was significantly delayed in the fellow eyes. It revealed that we should be alert to the occurrence of macular holes in the fellow eye.…”

Section: Discussionmentioning

confidence: 50%

Morphological and Functional Features in Patients with Idiopathic Macular Hole Treatment

Wang

Zhang

et al. 2022

IJGM

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“…A number of devices are currently used for healthy and pathological eyes, which include autorefractors, wavefront sensors, slit lamps, scanning laser ophthalmoscopes, and optical coherence tomography (OCT) devices. The state-of-the-art clinical method for an objective measurement of retinal D. Hillmann Thorlabs GmbH, Lübeck, Germany function is electroretinography (ERG) [3]. ERG measures electrical potential changes of photoreceptor cells, inner retinal cells, and ganglion cells in response to specific stimuli.…”

Section: Introductionmentioning

confidence: 99%

In Vivo FF-SS-OCT Optical Imaging of Physiological Responses to Photostimulation of Human Photoreceptor Cells

Hillmann

Pfäffle

Spahr

et al. 2019

High Resolution Imaging in Microscopy and Ophthalmology

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Multifocal Electroretinography

Abstract: Multifocal electroretinography (mfERG) provides functional and objective evidence of retinal dysfunction. We have found mfERG to be especially useful in the management of occult outer retinopathy and Stargardt's disease.

Cited by 5 publications

References 28 publications

Microperimetry and mfERG as functional measurements in diabetic macular oedema undergoing intravitreal ranibizumab treatment

Microperimetry and mfERG as functional measurements in diabetic macular oedema undergoing intravitreal ranibizumab treatment

Morphological and Functional Features in Patients with Idiopathic Macular Hole Treatment

In Vivo FF-SS-OCT Optical Imaging of Physiological Responses to Photostimulation of Human Photoreceptor Cells

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