Multifocal Epithelioid Hemangioma of the Penis: A Diagnostic and Therapeutic Challenge

Diagnostically Challenging Multifocal Penile Epithelioid Hemangioma Successfully Treated With Doxorubicin Hydrochloride

“…Intracytoplasmic vacuoles could be seen, rare mitosis, and absent cytologic atypia. 18 Our case demonstrated slitlike spaces with extravasated red blood cells and spindle cell proliferation, making it similar to Kaposi sarcoma; however, HHV8 was negative.…”

A rare case of cellular epithelioid hemangioma involving the penis

“…1,2 Only rarely has EH been reported to affect the penis, where histopathologic evaluation often reveals a highly cellular neoplasm that can cause concern for a malignant vascular tumor such as epithelioid hemangioendothelioma (EHE) or epithelioid angiosarcoma. 1,3,4 Immunohistochemistry may aid in definitive diagnosis when such histopathologic overlap occurs. [5][6][7][8][9][10][11]…”

“…EH most commonly affects young adults aged 20–50 years, classically in the head, neck, and distal extremity regions, although a wide range of additional anatomic locations may be involved including the trunk, deep soft tissue, bone, lung, lymph nodes, colon, eye, and spleen 1,2 . Only rarely has EH been reported to affect the penis, where histopathologic evaluation often reveals a highly cellular neoplasm that can cause concern for a malignant vascular tumor such as epithelioid hemangioendothelioma (EHE) or epithelioid angiosarcoma 1,3,4 . Immunohistochemistry may aid in definitive diagnosis when such histopathologic overlap occurs 5–11 …”