Multifocal ERG in chloroquine retinopathy: regional variance of retinal dysfunction

Kellner, Ulrich; Kraus, H; Foerster, Michael

doi:10.1007/s004170050016

Cited by 88 publications

(46 citation statements)

References 10 publications

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“…Recent studies have reported cases that, like our patient, had significant mfERG abnormalities despite being asymptomatic with normal or minimal clinical findings. [16][17][18] Typically, the mfERG will demonstrate a paracentral ring depression of signals around the fovea as was seen in our patient. 19 Moschos et al 19 reported that early cessation of hydroxychloroquine in patients resulted in improvement of mfERG patterns and reversible of toxicity over a period of 6 months.…”

Section: Discussionsupporting

confidence: 58%

Abnormalities on the multifocal electroretingram may precede clinical signs of hydroxychloroquine retinotoxicity

Teoh

Lim

Koh

et al. 2005

Eye

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Section: Discussionsupporting

confidence: 58%

Abnormalities on the multifocal electroretingram may precede clinical signs of hydroxychloroquine retinotoxicity

Teoh

Lim

Koh

et al. 2005

Eye

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“…31 The recording protocols have been described in detail elsewhere. 32,33 The EOG was recorded with a ramp test method. 34 Full-field ERG recordings were done with maximal dilated pupils using a Nicolet Spirit and Ganzfeld (Nicolet, Madison, Wisconsin, USA).…”

Section: Methodsmentioning

confidence: 99%

Morphology and Functional Characteristics in Adult Vitelliform Macular Dystrophy

Renner¹,

Tillack²,

Kraus³

et al. 2004

Retina

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Purpose: Detailed morphologic and functional evaluation of adult vitelliform macular dystrophy (AVMD).Methods: The records of 61 consecutive AVMD patients (inclusion criterion: vitelliform lesion smaller than one disk diameter at least in one eye) were evaluated retrospectively regarding visual acuity, color vision, perimetry, retinal pigment epithelium (RPE) autofluorescence, fluorescein angiography, electro-oculography, full-field and multifocal electroretinography, and molecular genetic evaluation of the VMD2 and RDS/peripherin genes.Results: The mean age of subjects was 54.6 years. Visual loss was variable (median, 0.6; range, 1.25-0.05). Color vision and visual field were normal in about half of the patients but presented defects with high variability in the remaining patients. Autofluorescence findings showed increased fluorescence within the foveal yellow lesion in 76%. In the majority of eyes, the amplitude of the 30 Hz flicker response of the full-field electroretinogram (72%) and the central P1 amplitude of the multifocal electroretinogram (63%) were reduced. Mutational analyses revealed a potentially disease-associated mutation in the RDS/peripherin gene in one patient.Conclusion: AVMD is characterized by late onset, slow progression, good prognosis, and high variability of morphologic and functional abnormalities resulting frequently in misdiagnosis. Autofluorescence findings indicate lipofuscin accumulation in the yellow lesion. Electroretinography revealed a generalized cone system dysfunction with increasing severity toward the fovea.RETINA 24:929 -939, 2004

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“…mfERG has been used in the assessment of chloroquine and hydroxychloroquine retinal toxicity. 130,162,190,192,204,234,285,303 The most characteristic mfERG findings specific to chloroquine and hydroxychloroquine retinal toxicity is the parafoveal reduction in P1 response amplitude and delays in N1 and P1 implicit times 130,192,303 (Fig. 7).…”

Section: Toxicity Due To Systemic Agents Chloroquine and Hydroxychlormentioning

confidence: 99%

The Clinical Applications of Multifocal Electroretinography: A Systematic Review

Lai

Chan

Lai

et al. 2007

Survey of Ophthalmology

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Abstract. Multifocal electroretinography (mfERG) is an investigation that can simultaneously measure multiple electroretinographic responses at different retinal locations by cross-correlation techniques. mfERG therefore allows topographic mapping of retinal function in the central 40--50 of the retina. The strength of mfERG lies in its ability to provide objective assessment of the central retinal function at different retinal areas within a short duration of time. Since the introduction of mfERG in 1992, mfERG has been applied in a large variety of clinical settings. This article reviews the clinical applications of mfERG based on the currently available evidence. mfERG has been found to be useful in the assessment of localized retinal dysfunction caused by various acquired or hereditary retinal disorders. The use of mfERG also enabled clinicians to objectively monitor the treatment outcomes as the changes in visual functions might not be reflected by subjective methods of assessment. By changing the stimulus, recording, and analysis parameters, investigation of specific retinal electrophysiological components can be performed topographically. Further developments and consolidations of these parameters will likely broaden the use of mfERG in the clinical setting.

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Multifocal ERG in chloroquine retinopathy: regional variance of retinal dysfunction

Cited by 88 publications

References 10 publications

Abnormalities on the multifocal electroretingram may precede clinical signs of hydroxychloroquine retinotoxicity

Abnormalities on the multifocal electroretingram may precede clinical signs of hydroxychloroquine retinotoxicity

Morphology and Functional Characteristics in Adult Vitelliform Macular Dystrophy

The Clinical Applications of Multifocal Electroretinography: A Systematic Review

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