Multifocal extramammary Paget’s disease-associated adenocarcinoma: a rare condition of flexoral skin of multiple sites

Wolf, Kristin; Stewart, Larissa R; Rapini, Ronald P.; Mutyambizi, Kudakwashe

doi:10.5070/d3221029792

Cited by 5 publications

(3 citation statements)

References 15 publications

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“…The other indicators are very similar, such as: the onset age is middle-aged and elderly people; All skin lesions are unilateral armpits; There are only a small number of concurrent local tumors. Wolf et al [ 8 ] believe that EMPD can present various clinical manifestations, so it is often misdiagnosed initially. Therefore, when recurrent erosive erythema occurs in the armpit area and the treatment effect is not satisfactory, it is recommended to undergo biopsy and immunopathological chemical examination early to rule it out.…”

Section: Discussionmentioning

confidence: 99%

Case report: A case of Paget disease outside the axillary breast

Zhou,

et al. 2024

Medicine

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Background: Extramammary Paget disease is a relatively rare and less malignant intraepithelial adenocarcinoma. t is found in areas with abundant distribution of apocrine sweat glands such as the external genitalia, external genitalia, and perianal area, with fewer armpits. The disease progresses slowly and is prone to misdiagnosis in clinical practice. Methods: We retrospectively analyzed a female patient. She had a left axillary mass for more than 2 years. Recently, the mass increased and the surface skin was ulcerated. Then she went to Jiangxi Provincial Dermatology Hospital for left axillary lesion resection, and the postoperative pathology showed Paget disease outside the breast. For further diagnosis and treatment, she came to our hospital. We diagnosed a tumor with uncertain or unknown dynamics in the left axillary breast. Under general anesthesia, left subaxillary mass resection, freezing and left breast cancer breast conserving surgery was performed. Results: The postoperative pathology of the left axillary mass combined with morphological and immunohistochemical results was consistent with Paget disease. Postoperative immunohistochemistry showed estrogen receptor (+, 20%), progesterone receptor (−), human epidermal growth factor receptor-2 (3+), Ki-67 (30%), cytokine7 (+), and p63 (−). Following up for 22 months, there has been no local recurrence, no swelling of the right axillary lymph node, no distant metastasis found on follow-up, and no complications such as upper limb lymphedema, upper limb sensory abnormalities, or motor disorders have been observed. Conclusion: Paget disease outside the axillary breast is relatively rare, and surgical resection is the best choice. The prognosis is good, and the recurrence rate is low.

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Section: Discussionmentioning

confidence: 99%

Case report: A case of Paget disease outside the axillary breast

Zhou,

et al. 2024

Medicine

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“…We searched the English and Chinese literature and summarised our cases and other 18 multiple EMPD cases previously reported (Table 1). [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] The mean age at diagnosis was 74 years. Of the 20 identified cases of multiple location EMPD, 19 were men, 17 (85%) of these men were Asian, and only 3 were caucasian, including the only female.…”

Section: Discussionmentioning

confidence: 99%

Concurrent extramammary Paget's disease involving the genitalia and axilla: Case report and literature review

Zhao

Zhang

et al. 2022

Aust J Dermatology

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Concurrent multiple primary extramammary Paget's disease (EMPD) is rare.Herein, we present two Chinese cases of concurrent primary EMPD involving both the genitalia and the axilla, and they also had a history of other malignancy.We also summarise the cases of multiple primary EMPD previously described in literature. Careful examination of all apocrine sweat gland-bearing sites and additional internal malignancies is recommended for patients with EMPD.

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“…Since then, our review of the literature identified 9 additional cases with only 1 case report of triple EMPD from Belgium and 1 from the United States, although the latter did not specify race and ethnicity. [2][3][4][5][6][7][8] EMPD is characteristically slow growing, and clinical features include pink or white scaly ulcerated plaques often described as ''strawberries and cream.'' 9 The pathogenesis of primary EMPD is not well understood but has been thought to arise from pluripotent intraepithelial or adnexal cells.…”

Section: Discussionmentioning

confidence: 99%