Multifocal renal cell carcinoma: A cytogenetic study

Kovács, Gyula; Hoene, Eberhard

doi:10.1007/bf00750734

Cited by 13 publications

(8 citation statements)

References 8 publications

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“…Four tumors (HA245, HA393, HA396, and FR527 in Table 1) did not exhibit the characteristic chromosomal pattern, but had typical papillary histology. Tumor HA245 developed in a kidney bearing a non-papillary RCC (Kovacs and Hoene, 1987).…”

Section: Resultsmentioning

confidence: 99%

Cytogenetics of papillary renal cell tumors

Kovács¹,

Füzesi

Emanual

et al. 1991

Genes Chromosomes & Cancer

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Chromosome aberrations were determined in short-term cultures of 18 papillary renal cell tumors, as well as in the cell line ACHN, and the results were evaluated together with 20 previously published cases. We found that chromosomes 7, 17, and 16 and the Y chromosome were specifically involved in the karyotype changes, marks benign papillary renal cell adenomas (ten cases). Malignant papillary renal cell carcinomas (29 cases) were characterized by additional trisomies: trisomy 16 occurred in 20 tumors, and trisomy 12 and 20 in 8 tumors each. Loss of the Y chromosome was observed in 7 of 9 benign and in 23 of 25 malignant tumors that developed in males. None of the papillary renal cell adenomas or carcinomas showed a loss of 3p or gain of a 5q segment, both of which are characteristic of common non-papillary renal cell carcinomas.

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Section: Resultsmentioning

confidence: 99%

Cytogenetics of papillary renal cell tumors

Kovács¹,

Füzesi

Emanual

et al. 1991

Genes Chromosomes & Cancer

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306

153

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“…In general, sporadic RCTs manifest as single tumours in one of the kidneys, although a few reports have been published on bilateral RCTs (Vermillion et al, 1972;Viets et al, 1977;Jacobs et al, 1980;Weaver et al, 1989). Occurrence of multiple tumours, referred to as renal adenomatosis because they are mostly adenomas (Syrjanen, 1979), has repeatedly been reported (Kovacs and Hoene, 1987;Mukamel et al, 1988;Cheng et al, 1991;Henn et al, 1993;Whang et al, 1995). These multiple tumours are frequently of the papillary/ chromophilic cell type (Thoenes et al, 1986).…”

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confidence: 99%

Involvement of multiple loci on chromosome 3 in renal cell cancer development

Berg

Buys

1997

Genes Chromosom. Cancer

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“…Multicentricity of RCT is well known, with adenomas frequently described in association with carcinomas. The extreme form with innumerable tumours has been described (7,12). The true prognostic value of estimates of nuclear V , could not be investigated in our study as there were too few examples of progression of disease, and the follow-up time was too short in some patients.…”

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confidence: 87%

Classification of tubulo‐papillary renal cortical tumours using estimates of nuclear volume

Brooks

Sørensen

Olsen

et al. 1993

APMIS

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The classification of renal cortical tumours is problematic, with no clear division of benign from malignant tumours. Unbiased stereological estimates of volume-weighted nuclear volume (nuclear Vc.) were obtained by point sampling of nuclear intercepts in a retrospective study of 36 variably sized tubulo-papillary basophilic cell renal cortical tumours. There was no clear pattern of evolution of nuclear V,, with increasing macroscopic tumour diameter. Estimates of nuclear Vv could not distinguish between 21 tumours classified as renal adenomas with macroscopic diameters < 3 cm (average nuclear V,,=241 pm3) and 15 tumours classified as renal cell carcinomas with diameters > 3 cm, or aggressive histological pattern (average nuclear V,,= 229 pm') (2p =0.68). In this subtype of renal cortical tumours, estimates of nuclear V,,, do not support the historical convention of using a 3 cm tumour diameter as the dividing line between adenomas and carcinomas, but support the theory of a single group of tumours. As most of the truly incidental renal cortical tumours are less than 1 cm in diameter, this limit could be considered. Such small benign cortical nodules have never been reported to metastasize, and would thus be excluded from being diagnosed and registered as malignant. Although this dividing line is again arbitrary, and cannot be justified by the stereological measurements, it is a practical solution to a clinical problem. There were too few examples of disease progression to assess the prognostic significance of nuciear 6,. in these tumours. 378small tumours not yet having metastasized (2). This reflects two viewpoints: one that RCT are actually two independent biological processes, and the other that they are a continuum of one biological process.The recent development of unbiased stereological methods has provided another means of studying these tumours. It is now possible to get an objective estimate of the threedimensional nuclear volume, which is independent of nuclear shape ( 3 , 4). Such quantitative estimates have been shown to be a useful tool

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Multifocal renal cell carcinoma: A cytogenetic study

Cited by 13 publications

References 8 publications

Cytogenetics of papillary renal cell tumors

Cytogenetics of papillary renal cell tumors

Involvement of multiple loci on chromosome 3 in renal cell cancer development

Classification of tubulo‐papillary renal cortical tumours using estimates of nuclear volume

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