Multifocal Renal Cell Carcinoma of Different Histological Subtypes in Autosomal Dominant Polycystic Kidney Disease

Na, Kiyong; Kim, Hyun Soo; Park, Yong Koo; Chang, Sung Goo; Kim, Youn Wha

doi:10.4132/koreanjpathol.2012.46.4.382

Cited by 12 publications

(13 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…While there is a much higher incidence of ESRD development in ADPKD patients, and ESRD leads to higher RCC risk, the data obtained at our institution supports the hypothesis that ADPKD patients still demonstrate higher rates of RCC than would be expected by ESRD alone. Furthermore, RCC in ADPKD patients develops at much younger ages (average 47 years) and is often bilateral (29%) and multicentric (25%) [12]. These rates are significantly higher than those found in sporadic RCC development, with 61 years being their median onset, 2% -6% are bilateral, and only 5% are multicentric [12] [13] [22].…”

Section: Discussionmentioning

confidence: 99%

The Association between Autosomal Dominant Polycystic Kidney Disease and Renal Cell Carcinoma

Hansen¹,

Derrick²,

Warriach³

et al. 2015

OJU

View full text Add to dashboard Cite

Objectives: The relationship between autosomal dominant polycystic kidney disease (ADPKD) and renal cell carcinoma (RCC) is investigated to determine a link that would guide management due to elevated RCC risk. Current literature is inconclusive on this topic. Methods: This study is a retrospective chart review of patients having undergone nephrectomy. Those with pathology and history consistent with ADPKD were reviewed for presence of RCC. Results: The review at this institution revealed RCC in 18% of ADPKD patients who underwent nephrectomy. These rates are significantly higher than those found in the general population, and even greater than those would be expected in patients suffering end-stage renal disease (ESRD). Conclusions: Due to the increased prevalence of RCC in ADPKD, clinicians managing patients with ADPKD should maintain a high index of suspicion. Our data suggest a link between ADPKD and RCC, most likely at the genetic level. In light of this, we feel that further genetic research is needed to potentially discover the link between these two disease processes.

show abstract

Section: Discussionmentioning

confidence: 99%

The Association between Autosomal Dominant Polycystic Kidney Disease and Renal Cell Carcinoma

Hansen¹,

Derrick²,

Warriach³

et al. 2015

OJU

View full text Add to dashboard Cite

show abstract

“…The association between polycystic kidney disease and RCC has been well documented [20-22], as well as the association of acquired polycytic kidney disease with renal tumors, which now represent a special type of tumor, already included into the WHO classification [1]. One of the characteristics of those tumors, in addition to the end stage kidney disease, is the abundance of calcium oxalate crystals.…”

Section: Discussionmentioning

confidence: 99%

“…However, no specific type of neoplasm has been descibed to occur in ADPKD. Most common histological subtypes assocated with ADPKD were clear cell RCC, followed by papillary and tubulocystic carcinoma [20-22]. Primary neuroendocrine tumors of the kidney, although rare, have also been reported to most commonly arise in the setting of acquired and congenital abnormalities, including polycystic kidney disease in 2% [23].…”

Section: Discussionmentioning

confidence: 99%

Thyroid-like follicular carcinoma of the kidney in a patient with nephrolithiasis and polycystic kidney disease: a case report

2013

View full text Add to dashboard Cite

Thyroid-like follicular carcinoma of the kidney (TLFC), a rare neoplasm with low malignant potential, is histologically similar to primary thyroid follicular carcinoma, but characteristically lacks thyroid immunohistochemical markers. We report a case of 34-year old patient with nephrolithiasis. Ultrasound revealed hepatorenal cysts consistent with adult type polycystic kidney disease (ATPKD) and a cytologically confirmed left kidney tumor. Nephrectomy specimen contained sharply demarcated lesion of unusual morphology. Tubular and cystic structures lined by mostly cuboidal cells and filled with amorphous eosinophillic material, reminiscent of follicular carcinoma of the thyroid gland, were diagnostic for TLFC. Thyroid markers were negative. To our knowledge this is the first report of TFLC associated to ATPKD. Brief review of previously published TFLCs, possible relationship between entities and differential diagnosis are discussed.Virtual slidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/8067946569612694

show abstract

“…This may explain why some studies have not demonstrated any significant statistical support for the association of ADPKD and RCC. However, the majority of papers published on this topic still continue to support the hypothesis of an association [7,12,13].…”

Section: Commentarymentioning

confidence: 99%

“…However, numerous studies have demonstrated that the rates of RCC in ADPKD patients are still higher when adjusted for time spent on RRT and compared with ESRD patients whose kidneys failed due to other causes than ADPKD [10,11,14]. Furthermore, RCC develops in ADPKD patients at much younger ages (average 47 years) and is often bilateral (30%) and multi-centric (25%) [7,13], much higher than found in sporadic RCC with 61 years being their median onset, 2%-6% are bilateral, and only 5% are multi-centric [12,13]. These clinical features of RCC in the ADPKD population are specific and unique, and the increased prevalence could be attributed to the associated ADPKD genetics.…”

Section: Commentarymentioning

confidence: 99%

Adult Dominant Polycystic Kidney Disease (ADPKD)

Riese¹

2017

J Med Surg Pathol

View full text Add to dashboard Cite

Autosomal-dominant polycystic kidney disease (ADPKD) is the most common inherited renal cystic disease affecting up to 10% of patients requiring some form of renal replacement therapy such as hemodialysis or kidney transplant. An association between autosomal-dominant polycystic kidney disease (ADPKD) and renal cell carcinoma (RCC) has been suspected since the 1930s. Many cases of RCC in ADPKD patients have been observed and published in the meantime. The gene mutations responsible for ADPKD have been discovered in the 1990s, however a direct genetic link to RCC has not been discovered so far, and the debate about an association between these two diseases is still controversial and ongoing. Many clinical experts who have published about this issue suspect a genetic link and state that ADPKD patients are much more prone to develop RCC than patients with end-stage renal disease (ESRD) of other causes. Currently there are no clear clinical guidelines regarding early nephrectomy in ADPKD patients with growing soft tissue nodules within their native kidneys. This commentary/ review on this important clinical issue describes the experience with these patients in one institution and gives an overview of the literature.

show abstract

Multifocal Renal Cell Carcinoma of Different Histological Subtypes in Autosomal Dominant Polycystic Kidney Disease

Cited by 12 publications

References 12 publications

The Association between Autosomal Dominant Polycystic Kidney Disease and Renal Cell Carcinoma

The Association between Autosomal Dominant Polycystic Kidney Disease and Renal Cell Carcinoma

Thyroid-like follicular carcinoma of the kidney in a patient with nephrolithiasis and polycystic kidney disease: a case report

Adult Dominant Polycystic Kidney Disease (ADPKD)

Contact Info

Product

Resources

About