Multifocal Rhizopus microsporus lung infection following brush clearing

Tsyrkunou, Artsiom; Ellison, Richard T.; Akalin, Ali; Wiederhold, Nathan P.; Sutton, Deanna A.; Lindner, Jonathan R.; Fan, Hongxin; Levitz, Stuart M.; Zivna, Iva

doi:10.1016/j.mmcr.2014.08.001

Cited by 12 publications

(10 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…oligosporus and R. microsporus var. tuberosus [ 9 ]. However, recently it has been proposed that they be reported as R. microsporus only, without mentioning variety, as they are all identical by sequence analysis.…”

Section: Discussionmentioning

confidence: 99%

Mucormycosis: Battle with the Deadly Enemy over a Five-Year Period in India

Chander

Kaur

Singla

et al. 2018

JoF

198

156

View full text Add to dashboard Cite

Mucormycosis is an emerging opportunistic fungal infection. Increasing immunocompromization, widespread use of antibacterial and antifungal agents (such as voriconazole prophylaxis), carcinomas, transplantation and lifestyle diseases such as diabetes are the main contributors to this situation. The predominant clinical manifestations of mucormycosis vary from host to host, with rhino-orbital-cerebral, pulmonary, cutaneous, and gastrointestinal infections being the most common. In India, the prevalence of mucormycosis is approximately 0.14 cases/1000 population, which is about 70 times the worldwide-estimated rate for mucormycosis. The present study was undertaken over a period of five years (January 2009–December 2014) to determine the prevalence of mucormycosis. The samples suspected of mucormycosis were examined by direct KOH wet mount and cultured on Sabouraud’s dextrose agar without actidione and on blood agar as per standard mycological techniques. Histopathological correlation was done for most of the cases. Antifungal susceptibility testing was performed by the EUCAST reference method. We identified a total of 82 cases of mucormycosis out of a total of 6365 samples received for mycological culture and examination during the said time period. Out of these, 56 were male patients and 27 were females. Most common presentation was rhino-orbito-cerebral (37), followed by cutaneous (25), pulmonary (14), oral cavity involvement (4) and gastrointestinal (2). The most common risk factors were diabetes and intramuscular injections. The fungi isolated were Rhizopus arrhizus (17), Apophysomyces variabilis (12), R. microsporus (9), Lichtheimia ramosa (8), Saksenaea erythrospora (5), Syncephalastrum racemosus (4), R. homothallicus (2), Rhizomucor pusillus (1), Mucor irregularis (1) and A. elegans (1). The mainstay of the treatment was amphotericin B, along with extensive surgical debridement whenever feasible. Most of the patients (50) recovered, but 25 died. The rest of the patients left against medical advice. “Nip in the Bud” should be the mantra for clinicians/surgeons for a favorable prognosis. Early diagnosis, prompt institution of appropriate antifungal therapy, surgical debridement whenever necessary, knowledge of risk factors and their timely reversal is the key for management.

show abstract

Section: Discussionmentioning

confidence: 99%

Mucormycosis: Battle with the Deadly Enemy over a Five-Year Period in India

Chander

Kaur

Singla

et al. 2018

JoF

198

156

View full text Add to dashboard Cite

show abstract

“…Species involved in this disease are Aspergillus fumigatus, A. flavus, A. niger and A. terreus [3,20,29]. Zygomycosis used to be very rare but has become an emerging infection because the growing numbers of risk factors like diabetes, neutropenia, bone marrow transplantation, long-term use of steroids, and chemotherapy in patients with haematological malignancy [2,8,31]. Species described as causative agents are Rhizopus microsporus and Lichtheimia (formerly Absidia) spp.…”

Section: Introductionmentioning

confidence: 99%

Effects of essential oil combinations on pathogenic yeasts and moulds

Horváth

Jenei

Vágvölgyi

et al. 2016

Acta Biologica Hungarica

View full text Add to dashboard Cite

Essential oils (EOs) can be used as alternative or complementary antifungal agents against human pathogenic moulds and yeasts. To reduce the effective dose of antimicrobial agents, EOs are combined which can lead to synergistic or additive effect. In this study the anti-yeast and anti-mould activities of selected EOs were investigated, alone and in combinations, against clinical isolates of Candida albicans, C. parapsilosis, Aspergillus fumigatus, A. terreus, Rhizopus microsporus, Fusarium solani and Lichtheimia corymbifera. Minimum inhibitory concentrations (MICs) were determined for the EOs of cinnamon, citronella, clove, spearmint and thyme. To investigate the combination effect of the EOs, fractional inhibitory concentrations (FICs) were defined by the checkerboard method and the type of interaction was determined by the FIC index (FICI). FIC index below 0.5 was considered as synergism and between 0.5 and 1 as additive effect. Strongest antifungal activity was showed by thyme EO with MIC values below 1.0 mg/ml. Combination of EOs resulted in additive or indifferent effect, with occasional "borderline synergism". The best combination was cinnamon with clove leading to additive effect in all cases.

show abstract

“…Advanced laboratory diagnostic testing using fungal PCR was needed to confirm R . microsporus [3,6].…”

Section: Discussionmentioning

confidence: 99%

Pulmonary mucormycosis masquerading as endobronchial tumour in an immunocompetent pregnant young lady

Huan

Nasaruddin

et al. 2020

Respirology Case Reports

View full text Add to dashboard Cite

Pulmonary mucormycosis is a rare but rapidly progressing and life‐threatening fungal infection, usually affecting immunocompromised patients. We report a case of a previously healthy young lady who presented with prolonged cough, weight loss, and haemoptysis. Imaging showed left hilar mass with infiltration into the left main bronchus and concurrent mediastinal lymphadenopathy. Flexible bronchoscopy revealed an endobronchial mass occluding the left main bronchus. Tumour debulking was performed using rigid bronchoscopy with cryoprobe and snares. Histopathological examination revealed inflamed tissue with fungal organism. Fungal polymerase chain reaction (PCR) confirmed Rhizopus microsporus . She was treated with two weeks of intravenous amphotericin‐B with complete clinical and radiological resolution.

show abstract

Multifocal Rhizopus microsporus lung infection following brush clearing

Cited by 12 publications

References 13 publications

Mucormycosis: Battle with the Deadly Enemy over a Five-Year Period in India

Mucormycosis: Battle with the Deadly Enemy over a Five-Year Period in India

Effects of essential oil combinations on pathogenic yeasts and moulds

Pulmonary mucormycosis masquerading as endobronchial tumour in an immunocompetent pregnant young lady

Contact Info

Product

Resources

About