Let (X, T ) and (Y, S) be two subshifts so that Y is a factor of X. For any asymptotically sub-additive potential Φ on X and a = (a, b) ∈ R 2 with a > 0, b ≥ 0, we introduce the notions of a-weighted topological pressure and a-weighted equilibrium state of Φ. We setup the weighted variational principle. In the case that X, Y are full shifts with one-block factor map, we prove the uniqueness and Gibbs property of aweighted equilibrium states for almost additive potentials having the bounded distortion properties. Extensions are given to the higher dimensional weighted thermodynamic formalism. As an application, we conduct the multifractal analysis for a new type of level sets associated with Birkhoff averages, as well as for weak Gibbs measures associated with asymptotically additive potentials on self-affine symbolic spaces.1991 Mathematics Subject Classification. Primary 37D35, Secondary 37B10, 37A35, 28A78.