Multifractal analysis of laser Doppler flowmetry signals before and after arm-cranking exercise in an older healthy population

Laser speckle contrast imaging (LSCI) is a newly commercialized imaging modality to monitor microvascular blood flow. Contrary to the well-known laser Doppler flowmetry (LDF), LSCI has the advantage of giving a full-field image of surface blood flow using simple instrumentation. However, laser speckle contrast images are not fully understood yet and their link with LDF signals still has to be studied. To quantify the similarity between LSCI and LDF symbolic sequences, we propose to use, for the first time, the index adapted from linguistic analysis and information theory proposed by Yang For this purpose, LSCI and LDF data were recorded simultaneously on the forearm of healthy subjects, at rest and during a vascular occlusion (biological zero). We show that there are different dynamical patterns for LSCI and LDF data, and the distances between these patterns differ through the space scales explored. Moreover, our results suggest that these different dynamical patterns could be linked to blood flow. The quantitative metric used herein therefore provides new information on LSCI and brings knowledge on links between LSCI and LDF.

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Concomitant Peripheral Neuropathy and Type 2 Diabetes Impairs Postexercise Cutaneous Perfusion and Flowmotion

Reynès

Beaume

Latil-Plat

et al. 2021

The Journal of Clinical Endocrinology &Amp; Metabolism

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Aim The study investigated changes in microvascular perfusion during post-exercise recovery in those with type 2 diabetes, with or without peripheral neuropathy, as well as in healthy controls and those with obesity. Methods Skin blood perfusion was assessed in each group using laser doppler flowmetry and laser speckle contrast imaging before and immediately after a six-minute walking test. Laser doppler flowmetry recordings underwent wavelet transformation to allow specific control mechanisms of blood perfusion to be studied (e.g. endothelial nitric oxide independent and dependent, neurogenic, myogenic, respiratory and cardiac mechanisms). Results Skin blood perfusion increased after exercise in all groups (22.3±28.1% with Laser speckle contrast imaging and 22.1±52.5% with laser doppler flowmetry). Throughout post-exercise recovery, the decrease was blunted in those with subclinical peripheral neuropathy and confirmed peripheral neuropathy when compared to the other three groups. After exercise, total spectral power increased in all groups. The relative contributions of each endothelial band was lower in those with confirmed peripheral neuropathy than in the healthy controls and those with obesity (nitric oxide-dependent function: 23.6±8.9% versus 35.5±5.8% and 29.3±8.8%, respectively; nitric oxide-independent function: 49.1±23.7% versus 53.3±10.4% and 64.6±11.4%, respectively). The neurogenic contribution decreased less in those with confirmed peripheral neuropathy and in those with type 2 diabetes alone, compared to those with subclinical peripheral neuropathy and those with obesity (-14.5±9.9% and -12.2±6.1% versus -26.5±4.7% and -21.7±9.4%, respectively). Conclusion Peripheral neuropathy, whatever the stage, altered the microvascular response to exercise via impaired endothelial and neurogenic mechanisms.

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Multifractal analysis of laser Doppler flowmetry signals before and after arm-cranking exercise in an older healthy population

Cited by 3 publications

References 25 publications

Processing of laser Doppler flowmetry signals from healthy subjects and patients with varicose veins: Information categorisation approach based on intrinsic mode functions and entropy computation

Processing of laser Doppler flowmetry signals from healthy subjects and patients with varicose veins: Information categorisation approach based on intrinsic mode functions and entropy computation

Linguistic Analysis of Laser Speckle Contrast Images Recorded at Rest and During Biological Zero: Comparison With Laser Doppler Flowmetry Data

Concomitant Peripheral Neuropathy and Type 2 Diabetes Impairs Postexercise Cutaneous Perfusion and Flowmotion

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