Multifunctional 3D Hierarchical Bioactive Green Carbon-Based Nanocomposites

Rabiee, Navid; Bagherzadeh, Mojtaba; Ghadiri, Amir Mohammad; Kiani, Mahsa; Fatahi, Yousef; Tavakolizadeh, Maryam; Pourjavadi, Ali; Jouyandeh, Maryam; Saeb, Mohammad Reza; Mozafari, Masoud; Shokouhimehr, Mohammadreza; Varma, Rajender S.

doi:10.1021/acssuschemeng.1c00781

Cited by 51 publications

(26 citation statements)

References 113 publications

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“… 47 − 49 Also, the iron-based nanoparticles/nanomaterials could be able to mimic the electron transfer between the cellular membranes; therefore, they are completely favorable to make strong interactions with the cells. 50 − 52 …”

Section: Introductionmentioning

confidence: 99%

Folic Acid-Adorned Curcumin-Loaded Iron Oxide Nanoparticles for Cervical Cancer

Farani

Azarian

Hossein

et al. 2022

ACS Appl. Bio Mater.

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Cancer is a deadly disease that has long plagued humans and has become more prevalent in recent years. The common treatment modalities for this disease have always faced many problems and complications, and this has led to the discovery of strategies for cancer diagnosis and treatment. The use of magnetic nanoparticles in the past two decades has had a significant impact on this. One of the objectives of the present study is to introduce the special properties of these nanoparticles and how they are structured to load and transport drugs to tumors. In this study, iron oxide (Fe 3 O 4 ) nanoparticles with 6 nm sizes were coated with hyperbranched polyglycerol (HPG) and folic acid (FA). The functionalized nanoparticles (10–20 nm) were less likely to aggregate compared to non-functionalized nanoparticles. HPG@Fe 3 O 4 and FA@HPG@Fe 3 O 4 nanoparticles were compared in drug loading procedures with curcumin. HPG@Fe 3 O 4 and FA@HPG@Fe 3 O 4 nanoparticles’ maximal drug-loading capacities were determined to be 82 and 88%, respectively. HeLa cells and mouse L929 fibroblasts treated with nanoparticles took up more FA@HPG@Fe 3 O 4 nanoparticles than HPG@Fe 3 O 4 nanoparticles. The FA@HPG@Fe 3 O 4 nanoparticles produced in the current investigation have potential as anticancer drug delivery systems. For the purpose of diagnosis, incubation of HeLa cells with nanoparticles decreased MRI signal enhancement’s percentage and the largest alteration was observed after incubation with FA@HPG@Fe 3 O 4 nanoparticles.

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Section: Introductionmentioning

confidence: 99%

Folic Acid-Adorned Curcumin-Loaded Iron Oxide Nanoparticles for Cervical Cancer

Farani

Azarian

Hossein

et al. 2022

ACS Appl. Bio Mater.

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“…Cancer is a complex phenomenon arising from RNA damage. Effective and rational cancer therapy is pertinent to the degree of success in understanding the mechanisms controlling the regeneration and proliferation of cancerous cells [ 27 , 28 , 29 ]. Targeted cancer therapy seeks to address the causation and visualize the generation and distribution of the cancerous cells [ 30 , 31 , 32 ].…”

Section: Mofs For Enhanced Cancer Therapymentioning

confidence: 99%

Metal–Organic Frameworks (MOFs) for Cancer Therapy

et al. 2021

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MOFs exhibit inherent extraordinary features for diverse applications ranging from catalysis, storage, and optics to chemosensory and biomedical science and technology. Several procedures including solvothermal, hydrothermal, mechanochemical, electrochemical, and ultrasound techniques have been used to synthesize MOFs with tailored features. A continued attempt has also been directed towards functionalizing MOFs via “post-synthetic modification” mainly by changing linkers (by altering the type, length, functionality, and charge of the linkers) or node components within the MOF framework. Additionally, efforts are aimed towards manipulating the size and morphology of crystallite domains in the MOFs, which are aimed at enlarging their applications window. Today’s knowledge of artificial intelligence and machine learning has opened new pathways to elaborate multiple nanoporous complex MOFs and nano-MOFs (NMOFs) for advanced theranostic, clinical, imaging, and diagnostic purposes. Successful accumulation of a photosensitizer in cancerous cells was a significant step in cancer therapy. The application of MOFs as advanced materials and systems for cancer therapy is the main scope beyond this perspective. Some challenging aspects and promising features in MOF-based cancer diagnosis and cancer therapy have also been discussed.

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“…Ultimately, biomaterial manipulation (such as functionalization with biomolecules and/or cell/bio molecular factor loading) is necessary to optimize angiogenic signaling pathways to support vascular cell attachment, proliferation, differentiation, or migration in soft and thick tissues. 56 , 57 Because without accurate modeling, most attempts to induce vascularization do not survive over a long time. 58 Furthermore, achieving precise replacement of different cell types within an organ scaffold is very difficult.…”

Section: Introductionmentioning

confidence: 99%

Cell-Seeded Biomaterial Scaffolds: The Urgent Need for Unanswered Accelerated Angiogenesis

Shokrani¹,

Shokrani²,

Sajadi³

et al. 2022

IJN

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One of the most arduous challenges in tissue engineering is neovascularization, without which there is a lack of nutrients delivered to a target tissue. Angiogenesis should be completed at an optimal density and within an appropriate period of time to prevent cell necrosis. Failure to meet this challenge brings about poor functionality for the tissue in comparison with the native tissue, extensively reducing cell viability. Prior studies devoted to angiogenesis have provided researchers with some biomaterial scaffolds and cell choices for angiogenesis. For example, while most current angiogenesis approaches require a variety of stimulatory factors ranging from biomechanical to biomolecular to cellular, some other promising stimulatory factors have been underdeveloped (such as electrical, topographical, and magnetic). When it comes to choosing biomaterial scaffolds in tissue engineering for angiogenesis, key traits rush to mind including biocompatibility, appropriate physical and mechanical properties (adhesion strength, shear stress, and malleability), as well as identifying the appropriate biomaterial in terms of stability and degradation profile, all of which may leave essential trace materials behind adversely influencing angiogenesis. Nevertheless, the selection of the best biomaterial and cells still remains an area of hot dispute as such previous studies have not sufficiently classified, integrated, or compared approaches. To address the aforementioned need, this review article summarizes a variety of natural and synthetic scaffolds including hydrogels that support angiogenesis. Furthermore, we review a variety of cell sources utilized for cell seeding and influential factors used for angiogenesis with a concentrated focus on biomechanical factors, with unique stimulatory factors. Lastly, we provide a bottom-to-up overview of angiogenic biomaterials and cell selection, highlighting parameters that need to be addressed in future studies.

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Multifunctional 3D Hierarchical Bioactive Green Carbon-Based Nanocomposites

Cited by 51 publications

References 113 publications

Folic Acid-Adorned Curcumin-Loaded Iron Oxide Nanoparticles for Cervical Cancer

Folic Acid-Adorned Curcumin-Loaded Iron Oxide Nanoparticles for Cervical Cancer

Metal–Organic Frameworks (MOFs) for Cancer Therapy

Cell-Seeded Biomaterial Scaffolds: The Urgent Need for Unanswered Accelerated Angiogenesis

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