Multifunctional and multimodality theranostic nanomedicine for enhanced phototherapy

Wang, Yu Peng; Zeng, Qingbing; Yan, Libiao; Lin, Siqi; Wang, Lina; Zhou, Dongfang

doi:10.1039/d2tb02345h

Cited by 6 publications

(6 citation statements)

References 53 publications

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“…However, their limited sensitivity to soft tissues is a major obstacle to their clinical use. Fortunately, the advent of MRI has addressed this issue by offering lower resolution but greater sensitivity to soft tissues through nonionizing radiation. − Since Mn 2+ possesses 5 unpaired electrons, it has been used as an ideal T1 contrast agent because the T1 contrast effect is generally manifested by the interaction between the electron spins of the contrast agent and the protons of water molecules. Thus, the presence of abundant PAA-Mn on the opposite side of JNPs has the potential to serve as a T1-weighted MR contrast.…”

Section: Discussionmentioning

confidence: 99%

Active Targeted Janus Theranostic Nanoplatforms Enable Chemo-Photothermal Therapy to Inhibit the Growth of Breast Cancer

Chen,

Hou,

Zhang

et al. 2023

Mol. Pharmaceutics

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Nanoscale structures have been developed to serve various functions in cancer therapy, encompassing areas such as diagnosis, biomedical visualization, tissue regeneration, and drug delivery. Based on biocompatible chitosan oligosaccharides (COS) and gold nanorods (GNRs), we designed the drug delivery systems (GNR@polyacrylic acid-Mn@COS Janus nanoparticles (JNPs)), which achieved paclitaxel (PTX) loaded on the side of GNRs, and the PAA-Mn domain served as magnetic resonance imaging contrast agents. This system was found to be effectively delivered to tumor sites through the enhanced permeability and retention (EPR) effect and the active target of the COS. The uniform JNPs selectively targeted cancer cells instead of normal cells through interacting with the COS on the surface of tumor cells, and the pH/NIR-responsive drug release behavior further enhanced their therapeutic effects. The in vivo effects of JNPs against tumors were evaluated using subcutaneous and orthotopic lung metastasis models, yielding promising outcomes for both tumor diagnosis and cancer treatment. In conclusion, the obtained JNPs hold great promise as a theranostic nanoplatform with synergistic chemotherapeutic and photothermal effects.

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Section: Discussionmentioning

confidence: 99%

Active Targeted Janus Theranostic Nanoplatforms Enable Chemo-Photothermal Therapy to Inhibit the Growth of Breast Cancer

Chen,

Hou,

Zhang

et al. 2023

Mol. Pharmaceutics

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“…Both the in vitro and in vivo experiments showed that HMnO 2 /C&P exhibited excellent antitumor effects through combined PDT and mPTT. [ 117 ] In another research, Zhang group reported a photothermal bacterium (PTB) that utilized facultative anaerobic bacterium Shewanella oneidensis MR‐1 ( S. oneidensis MR‐1) and palladium nanoparticles (PD‐NPS) for PTT (Figure 3B). PTB exhibited strong photothermal properties and tumor‐targeting ability.…”

Section: Nanomedicine Mediated Mpttmentioning

confidence: 99%

Section: Nanomedicine Mediated Mpttmentioning

confidence: 99%

Nanomedicine‐Enabled Mild Photothermal Therapy Strategies for Enhanced Antitumor Treatment

Li,

Zhu,

Dong

et al. 2024

Advanced NanoBiomed Research

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Photothermal therapy (PTT) has emerged as a promising approach for tumor ablation utilizing hyperthermia offers several advantages, including non‐invasiveness, spatiotemporal controllability, and notable therapeutic efficacy. However, the clinical application of PTT is challenged by the heat diffusion. To address this, mild PTT (mPTT) has gained attention as an alternative strategy, operating at temperatures below 45 °C, with remarkable antitumor effects and minimal thermal damage to nearby normal tissues. Despite these benefits, the expression of heat shock proteins (HSPs) induces thermal resistance, which limits the therapeutic potential and practical implementation of mPTT. Nanomedicines have emerged as a solution to overcome these challenges, offering improved solubility, prolonged circulation time, enhanced tumor accumulation, and controlled cargo release, surpassing the capabilities of small molecular HSP inhibitors. Herein, it has been aimed to discuss the current landscape of photothermal agents, elucidate the underlying mechanisms of mPTT, highlight the benefits of mPTT in combination therapy, and explore the potential of nanomedicines to enhance mPTT efficacy. Additionally, future directions for the development of mPTT are presented and the challenges that are needed to be addressed are identified, with the aim of encouraging further research contributions to advance mPTT toward clinical applications.

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“…Undoubtedly, these unique characteristics are particularly beneficial for anticancer applications, such as photodynamic therapy and magnetic resonance imaging. , MnO 2 can be easily decomposed into Mn 2+ , which has a strong magnetic resonance imaging signal. , As we all know, some anticancer drugs not only exhibit significant damage to normal cells but also have a reduced killing effect on tumor cells due to the influence of the tumor microenvironment . For instance, the complex tumor microenvironments can inhibit the anticancer effects of some chemotherapy drugs, such as doxorubicin and cisplatin (CDDP), which bind to GSH and H 2 O 2 , etc. − Fortunately, more and more studies have shown that nanostructured MnO 2 is of great significance in the delivery of anticancer drugs and enhancing the effectiveness of chemotherapy. − Generally, the MnO 2 nanocarriers for anticancer drug delivery usually exhibit satisfactory tumor microenvironment-responsive drug release properties, and the degraded Mn 2+ has important applications in magnetic resonance imaging. , …”

Section: Introductionmentioning

confidence: 99%

“…21,22 MnO 2 can be easily decomposed into Mn 2+ , which has a strong magnetic resonance imaging signal. 23,24 As we all know, some anticancer drugs not only exhibit significant damage to normal cells but also have a reduced killing effect on tumor cells due to the influence of the tumor microenvironment. 25 For instance, the complex tumor microenvironments can inhibit the anticancer effects of some chemotherapy drugs, such as doxorubicin and cisplatin (CDDP), which bind to GSH and H 2 O 2 , etc.…”

Section: Introductionmentioning

confidence: 99%

Mesoporous Manganese Dioxide-Coated Upconversion Nanoparticles for Smart Photoluminescence and Drug Delivery

Zhang,

Sui,

et al. 2024

Ind. Eng. Chem. Res.

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A novel multifunctional nanoplatform (UCNP@MnO 2 NPs) is proposed by combining the upconversion luminescence with glutathione (GSH)responsive performance of mesoporous MnO 2 . The active core−shell upconversion nanoparticles (UCNPs) were prepared by high-temperature pyrolysis and seed epitaxial growth methods. Subsequently, the UCNPs were modified and further coated with a mesoporous MnO 2 shell. Moreover, the UCNP@MnO 2 NPs were further supported by various forms of structural characterization methods. As an effective photoluminescence nanoplatform, relying on the fluorescence performance of UCNP, the mesoporous MnO 2 shell was designed as a fluorescence quencher and served as a GSH/H 2 O 2 recognizer. The results indicate that the UCNP@MnO 2 NP has excellent fluorescence quenching and recovery performance. Additionally, the mesoporous MnO 2 shell of the UCNP@MnO 2 NP is conducive to drug loading and release as a nanocarrier for drug delivery. As a result, the UCNP@MnO 2 NPs demonstrated satisfying drug-loading efficiency (ca. 55.98%) and GSH-responsive controlled drug release. The UCNP@MnO 2 NPs cumulatively released up to ca. 56.49% at GSH concentrations of 10 mM within 24 h. Furthermore, the UCNP@MnO 2 NPs exhibited an excellent degradation performance. Overall, this study suggests a novel nanoplatform for smart photoluminescence and drug delivery, which offers unique insights and guidance for fluorometric imaging, sensing, and treatment.

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Multifunctional and multimodality theranostic nanomedicine for enhanced phototherapy

Abstract: Photodynamic therapy (PDT) has attracted much attention in recent years for their favorable efficacy in cancer therapy. However, monotherapy triggered by PDT alone are insufficient to improve therapeutic efficiency mainly...

Cited by 6 publications

References 53 publications

Active Targeted Janus Theranostic Nanoplatforms Enable Chemo-Photothermal Therapy to Inhibit the Growth of Breast Cancer

Active Targeted Janus Theranostic Nanoplatforms Enable Chemo-Photothermal Therapy to Inhibit the Growth of Breast Cancer

Nanomedicine‐Enabled Mild Photothermal Therapy Strategies for Enhanced Antitumor Treatment

Mesoporous Manganese Dioxide-Coated Upconversion Nanoparticles for Smart Photoluminescence and Drug Delivery

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