Multifunctional antibiotic- and zinc-containing mesoporous bioactive glass scaffolds to fight bone infection

Heras, C.; Jiménez-Holguín, Javier; Doadrio, A.; Vallet‐Regí, María; Sánchez‐Salcedo, Sandra; Salinas, Antonio J.

doi:10.1016/j.actbio.2020.07.044

Cited by 51 publications

(34 citation statements)

References 44 publications

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“…Zinc has been implemented in dental and orthopedic biomaterials since it has a positive impact on osteoblastogenesis and activity of osteoblasts [ 10 ], but it also shows an antimicrobial effect [ 11 , 12 , 13 , 14 ]. This ion has been studied for its antimicrobial effect in synergic action with antibiotics [ 15 ]. The combination of MBG as particulate biomaterial with other, especially injectable biomaterials broadens its applicability.…”

Section: Introductionmentioning

confidence: 99%

Tailorable Zinc-Substituted Mesoporous Bioactive Glass/Alginate-Methylcellulose Composite Bioinks

et al. 2021

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Bioactive glasses have been used for bone regeneration applications thanks to their excellent osteoconductivity, an osteostimulatory effect, and high degradation rate, releasing biologically active ions. Besides these properties, mesoporous bioactive glasses (MBG) are specific for their highly ordered mesoporous channel structure and high specific surface area, making them suitable for drug and growth factor delivery. In the present study, calcium (Ca) (15 mol%) in MBG was partially and fully substituted with zinc (Zn), known for its osteogenic and antimicrobial properties. Different MBG were synthesized, containing 0, 5, 10, or 15 mol% of Zn. Up to 7 wt.% of Zn-containing MBG could be mixed into an alginate-methylcellulose blend (algMC) while maintaining rheological properties suitable for 3D printing of scaffolds with sufficient shape fidelity. The suitability of these composites for bioprinting applications has been demonstrated with immortalized human mesenchymal stem cells. Uptake of Ca and phosphorus (P) (phosphate) ions by composite scaffolds was observed, while the released concentration of Zn2+ corresponded to the initial amount of this ion in prepared glasses, suggesting that it can be controlled at the MBG synthesis step. The study introduces a tailorable bioprintable material system suitable for bone tissue engineering applications.

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Section: Introductionmentioning

confidence: 99%

Tailorable Zinc-Substituted Mesoporous Bioactive Glass/Alginate-Methylcellulose Composite Bioinks

et al. 2021

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“…Up to now, our research group, sometimes in collaboration with other research groups has been deeply interested in investigating the effect of included Co, Cu, Zn, Ga, Sr, and Ce in MBGs with SiO 2 contents close to 80% [ 16 , [89] , [90] , [91] , [92] , [93] , [94] , [95] ]. Particularly, we have developed MBG scaffolds containing 4% of ZnO, already investigated in three animal models.…”

Section: Expanding Mesoporous Glass Properties By Adding Inorganic Ionsmentioning

confidence: 99%

“…Therefore, the MBG with 4% of ZnO was selected for our later in vitro and in vivo studies [ 66 , 93 , 99 ]. The lower bactericidal capability of this MBG was proposed to be improved by adding small amounts of antibiotics [ 90 ]. The MBG with 4% of ZnO continues under study as a very promising candidate to be used in bone RM.…”

Section: Future Perspective Of Mesoporous Glasses In Bone Rmmentioning

confidence: 99%

Mesoporous bioactive glasses for regenerative medicine

Vallet‐Regí

Salinas

2021

Materials Today Bio

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Stem cells are the central element of regenerative medicine (RM). However, in many clinical applications, the use of scaffolds fabricated with biomaterials is required. In this sense, mesoporous bioactive glasses (MBGs) are going to play an important role in bone regeneration because of their striking textural properties, quick bioactive response, and biocompatibility. As other bioactive glasses, MBGs are mainly formed by silicon, calcium, and phosphorus oxides whose ions play an important role in cell proliferation as well as in homeostasis and bone remodeling process. A common improvement of bioactive glasses for RM is by adding small amounts of oxides of elements that confer them additional biological capacities, including osteogenic, angiogenic, antibacterial, anti-inflammatory, hemostatic, or anticancer properties. Moreover, MBGs are versatile in terms of the different ways in which they can be processed, such as scaffolds, fibers, coatings, or nanoparticles. MBGs are unique because their textural properties are so high that they still exhibit outstanding bioactive responses even after adding extra inorganic ions or being processed as scaffolds or nanoparticles. Moreover, they can be further improved by loading with biomolecules, drugs, and stem cells. This article reviews the state of the art and future perspectives of MBGs in the field of RM of hard tissues.

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“…This research was carried out by using, mainly, two designed controlled scaffold fabrication methods (Figure 1): rapid prototyping [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22] and GELPOR3D or analogous procedures [23][24][25][26][27][28][29][30][31][32][33][34][35]. In addition, foams have been synthesized by combining the sol-gel technique with the addition of a surfactant as a random macropore former that is thermally eliminated; the so-obtained inorganic foams are coated with gelatin or polycaprolactone (PCL) yielding tougher and more biocompatible scaffolds [36][37][38][39][40].…”

Section: Introductionmentioning

confidence: 99%

“…As shown in Figure 1 this additional stage is essential for scaffolds prepared by any technique that requires an aggressive chemical or thermal treatment to eliminate certain substances or to consolidate the obtained piece. This has been the strategy followed to incorporate different biomolecules: rifampicin, levofloxacin, zoledronic acid, osteostatin, etc., within scaffolds prepared by rapid prototyping [15][16][17]19,20]. In a similar way, the scaffolds' surface has been modified through its functionalization with different types of biomolecules.…”

Section: Introductionmentioning

confidence: 99%

Design of 3D Scaffolds for Hard Tissue Engineering: From Apatites to Silicon Mesoporous Materials

et al. 2021

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Advanced bioceramics for bone regeneration constitutes one of the pivotal interests in the multidisciplinary and far-sighted scientific trajectory of Prof. Vallet Regí. The different pathologies that affect osseous tissue substitution are considered to be one of the most important challenges from the health, social and economic point of view. 3D scaffolds based on bioceramics that mimic the composition, environment, microstructure and pore architecture of hard tissues is a consolidated response to such concerns. This review describes not only the different types of materials utilized: from apatite-type to silicon mesoporous materials, but also the fabrication techniques employed to design and adequate microstructure, a hierarchical porosity (from nano to macro scale), a cell-friendly surface; the inclusion of different type of biomolecules, drugs or cells within these scaffolds and the influence on their successful performance is thoughtfully reviewed.

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Multifunctional antibiotic- and zinc-containing mesoporous bioactive glass scaffolds to fight bone infection

Cited by 51 publications

References 44 publications

Tailorable Zinc-Substituted Mesoporous Bioactive Glass/Alginate-Methylcellulose Composite Bioinks

Tailorable Zinc-Substituted Mesoporous Bioactive Glass/Alginate-Methylcellulose Composite Bioinks

Mesoporous bioactive glasses for regenerative medicine

Design of 3D Scaffolds for Hard Tissue Engineering: From Apatites to Silicon Mesoporous Materials

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