Multifunctional Au@IPN-pNIPAAm nanogels for cancer cell imaging and combined chemo-photothermal treatment

Zhao, Xueqin; Wang, Tianxiao; Wen, Liping; Wang, Cai-ding; Wang, Dong; Shang, Ting; Shen, Lihua; Ren, Lei

doi:10.1039/c1jm10277j

Cited by 72 publications

(54 citation statements)

References 33 publications

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“…For example, to obtain the elastic constants tensor for CAB, Table 6. Elastic constants for tetragonal zirconia (GPa) [71,72]. C 44 C 66 C 12 C 13 327 264 59 64 100 62 Table 7.…”

Section: Model Parametersmentioning

confidence: 99%

Effect of variant strain accommodation on the three-dimensional microstructure formation during martensitic transformation: Application to zirconia

2015

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“…For example, to obtain the elastic constants tensor for CAB, Table 6. Elastic constants for tetragonal zirconia (GPa) [71,72]. C 44 C 66 C 12 C 13 327 264 59 64 100 62 Table 7.…”

Section: Model Parametersmentioning

confidence: 99%

Effect of variant strain accommodation on the three-dimensional microstructure formation during martensitic transformation: Application to zirconia

2015

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“…HEK293 cells stably expressing IL23R␣ and variants were plated in 96-well plate (20,000 cells) in triplicate. The next day the cells were assayed for levels of mitochondrial dehydrogenase activity by using MTT (64). Data and error bars represent the S.D.…”

Section: Discussionmentioning

confidence: 99%

IL23R (Interleukin 23 Receptor) Variants Protective against Inflammatory Bowel Diseases (IBD) Display Loss of Function due to Impaired Protein Stability and Intracellular Trafficking

Sivanesan

Beauchamp

Quinou

et al. 2016

Journal of Biological Chemistry

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Genome-wide association studies as well as murine models have shown that the interleukin 23 receptor (IL23R) pathway plays a pivotal role in chronic inflammatory diseases such as Crohn disease (CD), ulcerative colitis, psoriasis, and type 1 diabetes. Genome-wide association studies and targeted re-sequencing studies have revealed the presence of multiple potentially causal variants of the IL23R. Specifically the G149R, V362I, and R381Q IL23R␣ chain variants are linked to protection against the development of Crohn disease and ulcerative colitis in humans. Moreover, the exact mechanism of action of these receptor variants has not been elucidated. We show that all three of these IL23R␣ variants cause a reduction in IL23 receptor activation-mediated phosphorylation of the signaltransducing activator of transcription 3 (STAT3) and phosphorylation of signal transducing activator of transcription 4 (STAT4). The reduction in signaling is due to lower levels of cell surface receptor expression. For G149R, the receptor retention in the endoplasmic reticulum is due to an impairment of receptor maturation, whereas the R381Q and V362I variants have reduced protein stability. Finally, we demonstrate that the endogenous expression of IL23R␣ protein from V362I and R381Q variants in human lymphoblastoid cell lines exhibited lower expression levels relative to susceptibility alleles. Our results suggest a convergent cause of IL23R␣ variant protection against chronic inflammatory disease.Interleukin 23 receptors (IL23Rs) have been implicated in chronic inflammatory diseases through their role in initiating the differentiation of helper T cells (Th17). The Th17 pathway is important to control acute microbial infections (1-3), and deregulation of the pathway results in inflammatory bowel disease (IBD) 2 (4 -6). IL23R is expressed in specific subsets of T cells as well as other immune cells (7). Cells that express the IL23R polypeptide chain do not express IL12R␤2, which is also a partner for IL12R␤1 forming the interleukin 12 receptor (IL12R) (7). Recently, evidence has been presented that IL23R in type 3 innate lymphoid cells is involved in development of colitis through IL23 signaling (8). It is thus essential to understand how IL23R␣-protective variants affect IL23 signaling as evidence to support development of therapeutic strategies for IBD. To avoid confusion due to the nomenclature that denotes the IL23R heterodimer receptor from the individual chains, in this report the chain distinct to IL23R will be denoted as IL23R␣ and the heterodimer denoted as IL23R. IL23R signals through the interaction between two receptor chains, IL23R␣ and IL12R␤1, and together signals by binding IL23 cytokine (9, 10). IL23R␣ constitutively interacts with Janus kinase 2 (JAK2). Binding of IL23 by IL23R results in activation of JAK2 and subsequent phosphorylation of the IL23R followed by recruitment of STAT3 and STAT4 and their phosphorylation (9). Phosphorylated STAT3 and STAT4 both form homodimers that translocate to the nucleus to transcribe pro...

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“…Zhao et al prepared gold encapsulated IPN-pNIPAAm nanogels in a two step process consisting of monolayer growth, followed by polymerization and crosslinking. 107 Li et al synthesized poly(styrene-b-N-isopropylacrylamide) micelles and bound AuNPs to the surfaces. 47 Each of these approaches illustrates how hybrid polymer NPs vary widely from system to system.…”

Section: Polymeric Nanoparticle Compositesmentioning

confidence: 99%

“…These thermally responsive polymer-metal NP composites have been investigated for cancer therapy by combining the metal NP ability to generate heat with polymeric drug delivery. 12,19,28,37,47,90,106,107 Thus, the composite polymeric NPs can be irradiated with light, causing the metal NPs to generate heat, in turn resulting in polymer phase changes that can facilitate chemotherapy by drug release.…”

Section: Polymeric Nanoparticle Compositesmentioning

confidence: 99%

Tunable Nanostructures as Photothermal Theranostic Agents

2011

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The theranostic potential of several nanostructures has been discussed in the context of photothermal therapies and imaging. In the last several decades, the burden of cancer has grown rapidly, making the need for new theranostic approaches vital. Lasers have emerged as promising tools in cancer treatment, especially with the advent of photothermal therapies wherein light absorbing dyes or plasmonic gold nanoparticles are used to generate heat and achieve tumor damage. Recently, photoabsorbing nanostructures have materialized that can be employed in conjunction with lasers in the near-infrared region in order to enhance both imaging and photothermal effects. The incorporation of tunable nanostructures has resulted in improved specificity in cancer treatment. Silica-cored gold nanoshells and gold nanorods currently serve as the chief plasmonic structures for photothermal therapy. Although gold nanorods and silica-cored gold nanoshells have shown promise as therapeutic agents, over the past few years new nanostructures have emerged that offer comparable and even superior theranostic properties. In the present review, several theranostic agents and their impact on the development of more effective photothermal therapies for the treatment of cancer are discussed. These agents include hollow gold nanoshells, gold gold-sulfide nanoparticles, gold nanocages, carbon and titanium nanotubes, photothermal-based nanobubbles, polymeric nanoparticles and copper-based nanocrystals.

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Multifunctional Au@IPN-pNIPAAm nanogels for cancer cell imaging and combined chemo-photothermal treatment

Cited by 72 publications

References 33 publications

Effect of variant strain accommodation on the three-dimensional microstructure formation during martensitic transformation: Application to zirconia

Effect of variant strain accommodation on the three-dimensional microstructure formation during martensitic transformation: Application to zirconia

IL23R (Interleukin 23 Receptor) Variants Protective against Inflammatory Bowel Diseases (IBD) Display Loss of Function due to Impaired Protein Stability and Intracellular Trafficking

Tunable Nanostructures as Photothermal Theranostic Agents

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